Distinct antiviral signatures revealed by the magnitude and round of influenza virus replication in vivo
Louisa E. Sjaastad, Elizabeth J. Fay, Jessica K. Fiege, Marissa G. Macchietto, Ian A. Stone, Matthew W. Markman, Steven Shen, and Ryan A. Langlois
PNAS September 18, 2018 115 (38) 9610-...
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The seasonal flu is caused by different subtypes of Influenza A virus and typically leads to the death of half a million people each year. In order to better understand this virus and how it spreads, University of Minnesota Medical School researchers took a closer look at the cells inside...Today, 07:32 AM
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The number of outpatients in the summer and autumn alternating season sick high hospitals increasedSeptember 09, 2018, 15:30snip
With the end of the hot weather, the weather in Chongqing began to cool down after entering September, but the number of people suffering...Yesterday, 07:57 PM -
Source: https://www.forbes.com/sites/alicegw.../#b67d1e132874 Raising Kids With Religion Or Spirituality May Protect Their Mental Health: Study Alice G. Walton Contributor Sep 17, 2018, 01:40pm A new study fr...Yesterday, 07:05 PM
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Source: http://www.macaubusiness.com/macau-l...health-bureau/ MNANewsdesk10:21am Macau | Local case of Scrub Typhus detected - Health Bureau The city’s Health Bureau has announced that a 15-year old female student was diagnosed with Scrub Typhus, also known as Tsutsugamushi diseas...Yesterday, 06:43 PM
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Source: http://www.abc12.com/content/news/3-...493769131.html 3 different schools in Mid-Michigan with confirmed cases of viral meningitis Posted: Wed 5:09 PM, Sep 19, 2018 | Updated: Wed 7:08 PM, Sep 19, 2018 GENESEE COUNTY (WJRT) (09/19/18) - Three different schools in Mid-Michigan...Yesterday, 06:15 PM
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Source: https://english.vietnamnet.vn/fms/so...-hcm-city.html Last update 11:04 | 19/09/2018 Hand, foot and mouth cases on the rise at schools in HCM City VietNamNet Bridge – The number of hand, foot and mouth infections has surged at schools in HCM City, especially at kinde...Yesterday, 06:13 PM
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Source: https://www3.nhk.or.jp/nhkworld/en/news/20180919_20/ Rubella infections in Japan hit worst in 5 years Japan 17 hours ago Japan's health officials say rubella, or German measles, is spreading, with the number of patients since the start of this year the largest in 5 years. The National Institute of Infectious Diseases said ...Yesterday, 06:02 PM
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Source: https://www.telesurtv.net/english/ne...0919-0018.html Honduras Declares State Of Emergency Amid Mumps Outbreak Published 19 September 2018 (3 hours 48 minutes ago) The Honduran Ministry of Health announced a state of emergency for the ...Yesterday, 06:00 PM
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Source: http://www.cidrap.umn.edu/news-persp...an-sep-19-2018
News Scan for Sep 19, 2018
DRC Ebola vaccination; Smallpox vaccine sent to UK; Childhood deaths worldwide; Low global flu levels
Filed Under:
Monkeypox; Ebola; VHF; Smallpox; Public Health; Influenza, General
DRC Ebola vaccination drive tops 10,000 as cases hold steady
As the number of Ebola cases and deaths held steady...Yesterday, 05:55 PM -
Source: http://www.cidrap.umn.edu/news-persp...ted-us-produce
US officials probe Cyclospora spike, tainted US produce Filed Under: Cyclospora; Foodborne Disease Lisa Schnirring | News Editor | CIDRAP News | Sep 19, 2018 The US Centers for Disease Control and Prevention (CDC) said yesterday that 2,173 lab-confirmed domestically acquired ...Yesterday, 05:53 PM -
Source: http://www.cidrap.umn.edu/news-persp...ght-biodefense
White House shines high-level spotlight on biodefense Filed Under: Bioterrorism; Biosecurity Issues Lisa Schnirring | News Editor | CIDRAP News | Sep 18, 2018 The Trump Administration today released a new National Biodefense Strategy, along with an order from President Donald Trump that directs the Department of Health and Human ...Yesterday, 05:52 PM -
Streptococcus pyogenes, is the name of the bacteria that is causing deaths in Argentina. Although it is a known bacterium, which usually produces mild infections, such as pharyngitis, scarlet fever or skin infections, it is alerting health authorities. About the...Yesterday, 09:53 AM
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Source: https://ktul.com/news/local/three-ca...ty-of-oklahoma Three cases of mumps confirmed at University of Oklahoma by Austin Prickett, KOKH Staff Tuesday, September 18th 2018 NORMAN, Okla. (KOKH) - The Oklahoma State Department of Health says that several cases o...Yesterday, 05:57 AM
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J Int Med Res. 2018 Sep 13:300060518792795. doi: 10.1177/0300060518792795. [Epub ahead of print]
Rescue of four pediatric patients with severe influenza A (H3N2) in Weifang, China.
Li T1, Qi N1, Gao X1, Yu H1.
Author information
Abstract
In this report, we summarize...Yesterday, 01:39 AM -
J Infect Public Health. 2018 Sep 10. pii: S1876-0341(18)30134-5. doi: 10.1016/j.jiph.2018.08.005. [Epub ahead of print]
A review on current trends in the treatment of human infection with H7N9-avian influenza A.
Sivanandy P1, Zi Xien F2, Woon Kit L2, Tze Wei Y2, Hui En K2, Chia Lynn L2.
Author
...Yesterday, 01:38 AM -
Electron Physician. 2018 Aug 25;10(8):7217-7223. doi: 10.19082/7217. eCollection 2018 Aug.
Prevalence of seasonal influenza vaccination among primary healthcare workers in Arar city, Saudi Arabia.
Alenazi BR1, Hammad SM2,3, Mohamed AE4,5.
Author information
Abstract
Background:
Influenza outbreaks occur annually and have significant ramifications on the wellbeing of the population. Influenza is given high priority in Saudi Arabia where numerous reports of different types of influenza outbreaks have occurred in recent years.
Objective:
The study aimed to determine the prevalence of influenza vaccination among healthcare providers.
Methods:
The study employed a cross-sectional design, and data was collected using a predesigned questionnaire which was validated by a panel of experts and tested for reliability (Cronbach's alpha =0.8). All primary healthcare workers in Arar city (Saudi Arabia) were taken as a comprehensive sample between January and...Yesterday, 01:37 AM -
Int J Clin Pract. 2018 Oct;72(10):e13249. doi: 10.1111/ijcp.13249.
Seasonal influenza immunisation: Strategies for older adults.
Schaffner W1, van Buynder P2, McNeil S3, Osterhaus ADME4.
Author information
Abstract
Adults over the age of 60-65 years suffer...Yesterday, 01:36 AM -
Influenza Other Respir Viruses. 2018 Sep 14. doi: 10.1111/irv.12610. [Epub ahead of print]
Antigenic evolution of H3N2 influenza A viruses in swine in the United States from 2012 to 2016.
Bolton MJ1, Abente EJ1, Venkatesh D2, Stratton JA1, Zeller M1,3, Anderson TK1, Lewis NS2, Vincent AL1.
Author information
...Yesterday, 01:35 AM -
J Crit Care. 2018 Aug 24;48:172-177. doi: 10.1016/j.jcrc.2018.08.017. [Epub ahead of print]
Clinical characteristics, evolution, and treatment-related risk factors for mortality among immunosuppressed patients with influenza A (H1N1) virus admitted to the intensive care unit.
Garnacho-Montero J1, León-Moya...Yesterday, 01:35 AM -
Viruses. 2018 Sep 13;10(9). pii: E497. doi: 10.3390/v10090497.
Zoonotic Potential of Influenza A Viruses: A Comprehensive Overview.
Mostafa A1,2, Abdelwhab EM3, Mettenleiter TC4, Pleschka S5.
Author information
Abstract
Influenza A viruses (IAVs) possess a great zoonotic...Yesterday, 01:34 AM -
BMC Infect Dis. 2018 Sep 14;18(1):462. doi: 10.1186/s12879-018-3358-4.
Association between semi-quantitative microbial load and respiratory symptoms among Thai military recruits: a prospective cohort study.
Tam CC1,2, Offeddu V3, Anderson KB4,5, Weg AL5, Macareo LR5, Ellison DW5, Rangsin R6, Fernandez S5, Gibbons RV7,...Yesterday, 01:32 AM -
Influenza Other Respir Viruses. 2018 Sep 14. doi: 10.1111/irv.12611. [Epub ahead of print]
Replacement of neuraminidase inhibitor susceptible influenza A(H1N1) with resistant phenotype in 2008 and circulation of susceptible influenza A and B viruses during 2009-2013, South Africa.
Treurnicht FK1, Buys A1, Tempia S2,3, Seleka M1,...Yesterday, 01:31 AM -
J Control Release. 2018 Sep 12. pii: S0168-3659(18)30525-X. doi: 10.1016/j.jconrel.2018.09.006. [Epub ahead of print]
Advax augments B and T cell responses upon influenza vaccination via the respiratory tract and enables complete protection of mice against lethal influenza virus challenge.
Tomar...Yesterday, 01:30 AM -
Presse Med. 2018 Sep 12. pii: S0755-4982(18)30320-8. doi: 10.1016/j.lpm.2018.06.013. [Epub ahead of print]
[Quadrivalent influenza vaccine: What is changed and what are the benefits?]
[Article in French]
Mosnier A1, Launay O2, Martinez L3, Gavazzi G4, Josset L5, Crepey P6, Hannoun C7, Weil-Olivier...Yesterday, 01:29 AM -
J Pediatr Nurs. 2018 Sep - Oct;42:21-24. doi: 10.1016/j.pedn.2018.05.009. Epub 2018 Jun 14.
Severe Obesity in Children May Not Pose Independent Risk for Influenza Complications.
Neyer VL1, Woo JG2, Siegel RM2.
Author information
Abstract
PURPOSE:
Subsets of children are targeted for influenza vaccination due to known conditions that increase the risk of influenza complications. The purpose of this study was to determine if severe obesity in children suggests targeted vaccination.
DESIGN AND METHODS:
A retrospective chart review of a large Midwestern pediatric hospital identified 188 cases of influenza complications (defined as requiring hospitalization or death) aged 2 to <20 years old from August 1, 2010 through June 30, 2013. Severe obesity was defined as body mass index (BMI) ≥99% for age and gender, with patients grouped by severe obesity status (yes vs. no). Cases were reviewed for previously identified risk conditions for influenza complications (e.g., asthma, pneumonia, diabetes), and were classified as having or not having a known high risk condition.
RESULTS:
Of 188 cases, 174 (93%) had a high-risk condition, while only 14 (7%) had no known condition. All 14 (100%) with no known high-risk condition had a BMI <99%. All 15 (100%) with BMI ≥99% had a known high-risk condition. The association between severe obesity status and influenza complications was not statistically significant (p = 0.61).
CONCLUSIONS:
This suggests that severe obesity in children is not an independent high-risk condition for influenza complications defined as requiring hospitalization or resulting in death, once other known influenza risk factors are considered.
IMPLICATIONS:
Based on this data, clinicians should not target children for influenza vaccination based on weight status. We cannot comment...Yesterday, 01:28 AM -
Antiviral Res. 2018 Sep 13. pii: S0166-3542(18)30313-9. doi: 10.1016/j.antiviral.2018.09.007. [Epub ahead of print]
Comparison of early and recent influenza A(H1N1)pdm09 isolates harboring or not the H275Y neuraminidase mutation, in vitro and in animal models.
Abed Y1, Tu V1, Carbonneau J1, Checkmahomed L1, Venable MC1, Fage C1, Marie-Ève-Hamelin1, Dufresne SF2, Kobinger G1, Boivin G3.
Author information
Abstract
After 6 years of circulation in humans, a novel antigenic variant of influenza A(H1N1)pdm09 (i.e., A/Michigan/45/2015) emerged in 2015-16 and has predominated thereafter worldwide. Herein, we compared in vitro and in vivo properties of 2016 wild-type (WT) A/Michigan/45/15-like isolate and its H275Y neuraminidase (NA) variant to the original A/California/07/09-like counterparts. The H275Y mutation induced comparable levels of resistance to oseltamivir and peramivir without altering zanamivir susceptibility in both 2009 and 2016 isolates. In vitro, the two WT isolates had comparable replicative properties. The 2016-H275Y isolate had lower titers at 36 h post-inoculation (PI) (P ...Yesterday, 01:27 AM -
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Biomed Pharmacother. 2018 Sep 13;108:201-207. doi: 10.1016/j.biopha.2018.09.022. [Epub ahead of print]
Xin-Jia-Xiang-Ru-Yin alleviated H1N1-induced acute lung injury and inhibited the IFN-γ-related regulatory pathway in summer flu.
Li Q1, Pang P2, Zheng K3, Sun L4, Wang J5, Chen X6.
Author
...Yesterday, 01:26 AM -
Influenza Other Respir Viruses. 2018 Sep 16. doi: 10.1111/irv.12612. [Epub ahead of print]
Influence of meteorological parameters in the seasonality of influenza viruses circulating in Northern Cameroon.
Munshili Njifon HL1,2, Monamele CG1, Kengne Nde C3, Vernet MA1, Bouba G1, Tchatchouang S1,2, Njankouo Ripa M1, Tapondjou...Yesterday, 01:25 AM -
Prev Vet Med. 2018 Oct 1;158:71-77. doi: 10.1016/j.prevetmed.2018.07.015. Epub 2018 Jul 31.
Exponential random graph models to evaluate the movement of backyard chickens after the avian influenza crisis in 2004-2005, Thailand.
Poolkhet C1, Makita K2, Thongratsakul S3, Leelehapongsathon K3.
Author information
Abstract
The aim of this study was to use exponential random graph models (ERGMs) to explain networks of movement of backyard chickens in provinces which had been hotspots for avian influenza outbreaks in Thailand during 2004-2005. We used structured questionnaires to collect data for the period January to December 2009 from participants who were involved in the backyard chicken farming network in three avian influenza hotspots (Ratchaburi, Suphan Buri, and Nakhon Pathom provinces) in Thailand. From 557 questionnaires, we identified nodes, points of entry and exit from nodes, and activities relating to backyard chicken farming and movement of chickens, and generated ERGMs based on non-festive periods (Model 1) and the Chinese New Year period (Model 2). In Model 1, k-star (the central node is connected to k other nodes) connections were predominant (P ...Yesterday, 01:24 AM -
Prev Vet Med. 2018 Oct 1;158:78-88. doi: 10.1016/j.prevetmed.2018.07.012. Epub 2018 Jul 26.
Biosecurity practices on foie gras duck farms, Southwest France.
Delpont M1, Blondel V2, Robertet L2, Duret H2, Guerin JL3, Vaillancourt JP4, Paul MC3.
Author information
Ab
...Yesterday, 01:23 AM -
Hawaii J Med Public Health. 2018 Sep;77(9):226-230.
Are Rapid Influenza Antigen Tests Still Clinically Useful in Today's Molecular Diagnostics World?
Trombetta VK1,2, Chan YL1,2, Bankowski MJ1,2.
Author information
Abstract
Influenza virus infection and disease historically...Yesterday, 01:22 AM -
Cardiol Young. 2018 Sep 17:1-3. doi: 10.1017/S1047951118001580. [Epub ahead of print]
Purulent pericarditis secondary to influenza and community-acquired methicillin-resistant Staphylococcus aureus co-infection.
Morparia K1, Peshkovsky C2, Kalyanaraman M1.
Author information
...Yesterday, 01:22 AM -
Viral Immunol. 2018 Sep 15. doi: 10.1089/vim.2018.0072. [Epub ahead of print]
A Comparison of Toll-Like Receptor 5 and 21 Ligands as Adjuvants for a Formaldehyde Inactivated H9N2 Avian Influenza Virus Vaccine in Chickens.
Astill J1, Alkie T1, Yitbarek A1, Taha-Abdelaziz K1,2, Shojadoost B1, Petrik...Yesterday, 01:19 AM -
Vector Borne Zoonotic Dis. 2018 Sep 15. doi: 10.1089/vbz.2018.2299. [Epub ahead of print]
Did the Highly Pathogenic Avian Influenza A(H7N9) Viruses Emerged in China Raise Increased Threat to Public Health?
Zhu W1, Yang L1, Shu Y1,2.
Author information
Abstract
The...Yesterday, 01:14 AM -
PLoS Biol. 2018 Sep 17;16(9):e3000008. doi: 10.1371/journal.pbio.3000008. [Epub ahead of print]
Destabilized adaptive influenza variants critical for innate immune system escape are potentiated by host chaperones.
Phillips AM1, Ponomarenko AI1, Chen K1, Ashenberg O2, Miao J3, McHugh SM3,...Yesterday, 01:13 AM -
Source: https://www.journalducameroun.com/en...nimals-report/ Sierra Leone: Foot, Mouth disease outbreak kill 500 animals-Report Published on 18.09.2018 at 10h21 by APA News About 500 animals, including small ruminants like goats and ship...September 18th, 2018, 04:57 PM
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Source: http://www.cidrap.umn.edu/news-persp...an-sep-18-2018
News Scan for Sep 18, 2018
Low MMR uptake in UK; E coli preventive approved
Filed Under:
Measles; E coli; Childhood Vaccines; Foodborne Disease
Uptake of MMR vaccine falls to 91.2% in the UK
For the fourth year in a row, uptake of the measles, mumps,...September 18th, 2018, 04:54 PM -
Source: http://www.cidrap.umn.edu/news-persp...an-sep-18-2018
Stewardship / Resistance Scan for Sep 18, 2018
Antimicrobial stewardship in clinics; Antibiotic use in US seniors; Gut microbiota and bloodstream infections
Filed Under:
Antimicrobial Stewardship
New York study finds need for stewardship programs in outpatient cl
...September 18th, 2018, 04:53 PM
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