Source: http://www.cidrap.umn.edu/news-persp...an-mar-21-2019
News Scan for Mar 21, 2019
CDC updates Zika guidelines; Investments to end TB; Foodborne disease in soldiers; Yellow fever vaccine in Sudan; Cryptosporidium in groundwater
Filed Under:
Cryptosporidium; Zika; Tuberculosis; Foodborne Disease; Yellow Fever
CDC eases travel restrictions for pregnant women looking to avoid Zika
The US Centers for Disease Control...
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Source: http://www.cidrap.umn.edu/news-persp...-reappear-beni
Ebola total approaches 1,000 as cases reappear in Beni Filed Under: Ebola; VHF Lisa Schnirring | News Editor | CIDRAP News | Mar 21, 2019 Continuing a recent surge in new Ebola cases, the Democratic Republic of the Congo's (DRC's) health ministry reported 11 more cases today, including 2 in...Today, 05:31 PM -
Source: http://www.cidrap.umn.edu/news-persp...vaccine-strain
WHO reveals delayed pick for H3N2 flu vaccine strain Filed Under: Influenza Vaccines Lisa Schnirring | News Editor | CIDRAP News | Mar 21, 2019 After waiting an extra month to decide on the H3N2 strain, World Health Organization (WHO) vaccine advisors today finalized th...Today, 05:30 PM -
Source: http://www.cidrap.umn.edu/news-persp...-decline-small
TB in US at all-time low, but global decline small Filed Under: Tuberculosis Stephanie Soucheray | News Reporter | CIDRAP News | Mar 21, 2019 The US Centers for Disease Control and Prevention (CDC) released new numbers today about tuberculosis (TB) in the United States in advance of World TB Day, which t...Today, 05:28 PM -
Source: http://www.voicenews.com/news/three-...4602c9330.html Three likely mumps cases confirmed in St. Clair County Health officials encourage up-to-date vaccines By Katelyn Larese Mar 21, 2019 Updated 1 hr ago State and loc...Today, 02:36 PM
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Influenza A(H3N2) virus exhibiting reduced susceptibility to baloxavir due to a polymerase acidic subunit I38T substitution detected from a hospitalised child without prior baloxavir treatment, Japan, January 2019
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19 March 2019
Government, WFP investigate any link between Karamoja illness and Super Cereal KAMPALA - The Government of Uganda and United Nations World Food Programme (WFP) are investigating whether there is a connection between recent illnesses reported in two districts in Karamoja and Super Cereal, a fortified blended food distributed by WFP for prevention of malnutrition. On Tuesday, 12th, 2019, the Ministry of Health received an a...Today, 01:24 PM -
Mysterious Disease Kills 42 Children In Kanchibiya March 21, 2019 15 0 Kanchibiya member of parliament Dr. Martin Malama claims a mysterious disease has killed 42 children in 3 weeks , in Kapilya Village in Chief Chiundaponde’s Chiefdom in Kanchibiya Constituency. Dr. Malama has told diamond ...Today, 12:32 PM
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https://abc13.com/shelter-in-place-f...t-itc/5209552/ Shelter-in-place issued for Deer Park, Galena Park due to elevated benzene levels at ITC
By Jeff Ehling
Updated 4 minutes agoToday, 11:04 AM -
On The First Day Of Spring, A Disease Blogger's Thoughts Turn To . . . .
Credit Spencer J. Fox
#13,946
Spring officially arrived a little over 12 hours ago in the Northern Hemisphere, and while novel influenza activity has been fairly subdued for the past year, this is the time of year when we tend to see the emergence of new flu viruses.- A decade ago, a new soon-to-become-a-pandemic H1N1 virus was beginning to spread from pigs to humans in Mexico, although we wouldn't be alerted until the last week of April, 2009.
- Six years ago, three patients were hospitalized in
Today, 09:57 AM -
Russia looks forward to expanding exports of poultry meat to China
2019-03-21 08:19
"In the next few years, Russia will substantially increase its exports of poultry to China." Russia’s Tass news agency reported on the 19th that Russian Agriculture Minister Patrushev...Today, 08:12 AM -
Source: https://www.wptv.com/news/region-n-p...break-of-toads Palm Beach Gardens community concerned over outbreak of poisonous toads Posted: 10:56 AM, Mar 20, 2019 Updated: 7:27 PM, Mar 20, 2019 By: Ryan Hughes PALM BEACH GARDENS, Fla. — Thousands o...Yesterday, 11:25 PM
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Source: http://outbreaknewstoday.com/sweden-...utbreak-56886/ Sweden reports ‘parrot disease’ outbreak by News Desk March 20, 2019 Swedish public health authorities, Folkhalsomyndigheten, is reporting (computer translated) an outbreak of psittacosis, or parrot disease, since November 2018. Accord...Yesterday, 11:21 PM
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Source: https://www.cbc.ca/news/health/smoki...inds-1.5063745 Smoking strong pot daily raises psychosis risk, study finds Researchers analyzed data from a dozen sites across Europe and Brazil from 2010 to 2015 The Associated Press · Posted: Mar 20, 2019 2:45 AM ET | Last Updated: March 2...Yesterday, 10:57 PM
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Source: http://www.cidrap.umn.edu/news-persp...an-mar-20-2019
News Scan for Mar 20, 2019
Gloves, gowns, and MDROs; WHO drug-resistant TB guidelines; Antibiotic development partnership; Lung disease bacteria in tap water
Filed Under:
Antimicrobial Stewardship; Tuberculosis; Legionella
Contamination with MDROs after patient interaction common, study finds
Researchers...Yesterday, 05:08 PM -
Source: http://www.cidrap.umn.edu/news-persp...-continues-drc
Spike in Ebola cases continues in DRC Filed Under: Ebola; VHF Stephanie Soucheray | News Reporter | CIDRAP News | Mar 20, 2019 According to the World Health Organization's Ebola dashboard, officials today recorded 12 new Ebola cases in the ongoing outbreak in North Kivu and Ituri provinces in t...Yesterday, 05:07 PM -
Source: https://www.wspa.com/news/2nd-case-o...-co/1864238372 2nd case of mumps reported at Westside H.S. in Anderson Co. By: WSPA Staff Posted: Mar 20, 2019 05:44 PM EDT Updated: Mar 20, 2019 05:47 PM EDT ANDERSON COUNTY, SC (WSPA) - South Carolina Department of Health and...Yesterday, 04:53 PM
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Source: https://www.straitstimes.com/singapo...-start-of-year Spike in measles cases since start of year Published 36 min ago 38 cases in first 11 weeks of 2019 the highest since 2015; MOH says no evidence of further spread Felicia Choo The number of measles cases since the start of ...Yesterday, 04:51 PM
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Emerg. Microbes & Inf.: H5N1 Exposure & Human Seroconversion - Cameroon.
#13,944
Just over two years ago, in The Challenge Of Avian Flu Surveillance In Sub-Saharan Africa, we looked at one of the big mysteries surrounding the H5N1 virus;the lack of reported human infections in Africa outside of Egypt. West Africa, in particular, has reported a great many HPAI H...Yesterday, 07:16 AM -
Commun Dis Intell (2018). 2019 Mar 15;43. doi: 10.33321/cdi.2019.43.7.
Anatomy of a seasonal influenza epidemic forecast
Moss R1, Zarebski AE2, Dawson P3, Franklin LJ4, Birrell FA5, McCaw JM6.
Author information
Abstract
Bayesian methods have been used to predict the timing of infectious disease epidemics in various settings and for many infectious diseases, including seasonal influenza. But integrating these techniques into public health practice remains an ongoing challenge, and requires close collaboration between modellers,...Yesterday, 02:39 AM -
Acta Virol. 2019;63(1):121-125. doi: 10.4149/av_2019_116.
Isolation of H8N4 avian influenza virus from wild birds in Shanghai, China.
Tang W, Li X, Hu CH, Zhu C, Li Z, Wu D, Wang T, He G.
Abstract
The H8 subtype viruses are rarely isolated from wild ducks. Shanghai is one of the important wintering or stopover sites on the East Asia-Australia Migration Flyway. An influenza virus, subtype H8N4, was firstly isolated from a common teal (Anas crecca) in Shanghai during 2017-2018 in this study. To clarify the genetic...Yesterday, 02:39 AM -
J Infect. 2019 Mar 14. pii: S0163-4453(19)30077-5. doi: 10.1016/j.jinf.2019.03.008. [Epub ahead of print]
Human-isolated H7N9 obtained internal genes from duck and human influenza viruses.
Pu Z1, Yang J1, Shen X1, Irwin DM2, Shen Y3.
Author information
PMID: 30880145 DOI: 10.1016/j.jinf.2019.03.008
...Yesterday, 02:38 AM -
Indian J Med Microbiol. 2018 Oct-Dec;36(4):526-531. doi: 10.4103/ijmm.IJMM_18_272.
A study of influenza 2017-2018 outbreak in Andhra Pradesh, India.
Mudhigeti N1, Racherla RG1, Mahalakshmi PA1, Pamireddy ML1, Nallapireddy U1, Kante M1, Kalawat U1.
Author information
Abstract
Background and Objectives:
Influenza virus is a typical human pathogen causing serious respiratory illness resulting in significant mortality throughout the globe. Andhra Pradesh witnessed the first case of influenza A H1N1 in India from Hyderabad (now in Telangana)...Yesterday, 02:37 AM -
Front Immunol. 2019 Mar 1;10:336. doi: 10.3389/fimmu.2019.00336. eCollection 2019.
Mechanisms of Bacterial Superinfection Post-influenza: A Role for Unconventional T Cells.
Paget C1,2, Trottein F3,4,5,6,7.
Author information
Abstract
Despite the widespread application of vaccination programs and antiviral drug treatments, influenza viruses are still among the most harmful human pathogens. Indeed, influenza results in significant seasonal and pandemic morbidity and mortality. Furthermore, severe bacterial infections can occur...Yesterday, 02:36 AM -
Comput Math Methods Med. 2019 Feb 7;2019:9248246. doi: 10.1155/2019/9248246. eCollection 2019.
Spatiotemporal Distributions and Dynamics of Human Infections with the A H7N9 Avian Influenza Virus.
Chen Y1, Wen Y1.
Author information
Abstract
In 2013 in mainland China, a novel avian influenza virus H7N9 began to infect humans and had aroused severe fatality in the infected humans, followed by the annual outbreaks. By methods of GIS and kriging interpolation, we get the geographical distributions. We obtain the longitudinal...Yesterday, 02:36 AM -
Prior Vaccination and Effectiveness of Communication Strategies Used to Describe Infectious DiseasesEmerg Infect Dis. 2019 Apr;25(4):821-823. doi: 10.3201/eid2504.171408.
Prior Vaccination and Effectiveness of Communication Strategies Used to Describe Infectious Diseases.
Valley TS, Scherer AM, Knaus M, Zikmund-Fisher BJ, Das E, Fagerlin A.
Abstract
We tested the effect of prior vaccination on response to communication strategies in a hypothetical news article about an influenza pandemic. Vaccinated were more likely than nonvaccinated participants to plan future vaccination, and future vaccination intent was greater with certain...Yesterday, 02:35 AM -
Emerg Infect Dis. 2019 Apr;25(4):838-840. doi: 10.3201/eid2504.181554.
Reduced Susceptibility to Neuraminidase Inhibitors in Influenza B Isolate, Canada.
Abed Y, Fage C, Lagüe P, Carbonneau J, Papenburg J, Vinh DC, Boivin G.
Abstract
We identified an influenza B isolate harboring a Gly407Ser neuraminidase substitution in an immunocompromised patient in Canada before antiviral therapy. This mutation mediated reduced susceptibility to oseltamivir, zanamivir, and peramivir, most likely by preventing interaction with the catalytic Arg374...Yesterday, 02:34 AM -
Pediatr Infect Dis J. 2019 Apr;38(4):355-361. doi: 10.1097/INF.0000000000002165.
The Risk of Serious Bacterial Infection in Febrile Infants 0-90 Days of Life With a Respiratory Viral Infection.
Nicholson EG1,2, Avadhanula V2, Ferlic-Stark L2, Patel K2, Gincoo KE2, Piedra PA1,2.
Author information
Abstract
BACKGROUND:
Molecular diagnostic methods enhance the sensitivity and broaden the spectrum of detectable respiratory viruses in febrile infants ≤90 days of life. We describe the occurrence of respiratory viruses in...Yesterday, 02:33 AM -
Pediatr Infect Dis J. 2019 Apr;38(4):362-369. doi: 10.1097/INF.0000000000002164.
Characteristics and Outcomes of Young Children Hospitalized With Laboratory-confirmed Influenza or Respiratory Syncytial Virus in Ontario, Canada, 2009-2014.
Buchan SA1,2, Chung H3, Karnauchow T4,5, McNally JD4, Campitelli MA3, Gubbay JB2,6,7, Katz K6,8, McGeer AJ1,6,9, Richardson DC10, Richardson SE6,7, Simor A6,11, Smieja M12, Zahariadis G13,14, Tran D7,15, Crowcroft NS1,2,6, Rosella LC1,2,3, Kwong JC1,2,3,16,17.
Author information
Abstract
...Yesterday, 02:32 AM -
Hum Vaccin Immunother. 2019 Mar 18. doi: 10.1080/21645515.2019.1593726. [Epub ahead of print]
Non-familial paid caregivers as potential flu carriers and cause of spread: the primary prevention of flu measured through their adhesion to flu vaccination campaigns-A Florentine experience.
Bonaccorsi G1, Pieralli F2, Innocenti M2, Milani C2, Del Riccio M2, Bechini A1, Boccalini S1, Bonanni P1, Lorini C1.
Author information
Abstract
INTRODUCTION:
Influenza vaccination is recommended for caregivers of elderly people. In a study aimed at assessing...Yesterday, 02:31 AM -
Respirology. 2019 Mar 18. doi: 10.1111/resp.13524. [Epub ahead of print]
Novel endosomal NOX2 oxidase inhibitor ameliorates pandemic influenza A virus-induced lung inflammation in mice.
To EE1, Luong R1, Diao J2, O' Leary JJ3,4,5, Brooks DA6, Vlahos R1, Selemidis S1,7.
Author information
Abstract
BACKGROUND AND OBJECTIVE:
Influenza A viruses (IAV) cause respiratory tract infections that can be fatal when the virus spreads to the alveolar space (i.e. alveolitis), and this is mainly observed with highly pathogenic strains. Reactive oxygen species...Yesterday, 02:30 AM -
Influenza Other Respir Viruses. 2019 Mar 18. doi: 10.1111/irv.12641. [Epub ahead of print]
Avian influenza A (H9N2) virus infections among poultry workers, swine workers, and the general population in Beijing, China, 2013-2016: A serological cohort study.
Ma C1,2, Cui S1,2, Sun Y1,2, Zhao J1,2, Zhang D1,2, Zhang L1,2, Zhang Y1,2, Pan Y1,2,3, Wu S1,2, Duan W1,2, Zhang M1,2, Yang P1,2,3, Wang Q1,2.
Author information
Abstract
BACKGROUND:
Few studies have reported on the seroprevalence of antibodies against avian influenza A (H9N2) virus and the incidence...Yesterday, 02:29 AM -
Vet Immunol Immunopathol. 2019 Mar;209:78-83. doi: 10.1016/j.vetimm.2019.02.007. Epub 2019 Mar 4.
Intranasally administered polyethylenimine adjuvanted influenza M2 ectodomain induces partial protection against H9N2 influenza A virus infection in chickens.
Hajam IA1, Kim J1, Lee JH2.
Author information
Abstract
This study aimed to investigate whether intranasally coadministered four tandem copies of extracellular domains of M2 (M2e) and polyethyleneimine (PEI), a mucosal adjuvant, can protect chickens against H9N2 influenza A virus infection. Groups of chickens were intranasally vaccinated with M2e plus PEI adjuvant, M2e alone or PEI adjuvant, and antibody (serum IgG and mucosal IgA) and cellular (CD4+ T cells and IFN-γ levels) immune responses were measured post-vaccination. We demonstrated that the chickens vaccinated with M2e plus PEI adjuvant showed significantly (p < 0.05) higher M2e-specific systemic IgG and mucosal IgA responses compared to the chickens that received either M2e alone or PEI adjuvant. The IgA responses measured in lungs were almost comparable to that of the serum IgG levels. Upon restimulation of the vaccinated peripheral blood mononuclear cells (PBMCs) with M2e antigen, significantly (p < 0.05) higher IFN-γ levels were observed only in M2e plus PEI adjuvant vaccinated group. Lymphoproliferative and CD4+ T cell responses, as measured by MTT-based assay and flow cytometry, respectively, were also observed significantly (p < 0.05) higher in M2e plus PEI adjuvant vaccinated chickens. On challenge with the H9N2 virus (104TCID50) at 28th day post-vaccination, M2e plus PEI adjuvant vaccinated group exhibited lower lung inflammation and viral load compared to the chickens treated with either M2e alone or PEI adjuvant. In summary, we show that intranasally coadministered M2e and PEI adjuvant can elicit humoral and cell-mediated immune responses and can reduce viremia levels in chickens post H9N2 infection in chickens.
Copyright © 2019 Elsevier B.V. All rights reserved.
KEYWORDS:
Chickens; H9N2 influenza A virus; M2e; Polyethyleneimine adjuvant; Vaccine
PMID: 30885310 DOI: 10.1016/j.vetimm.2019.02.007
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Vaccine. 2019 Mar 15. pii: S0264-410X(19)30315-9. doi: 10.1016/j.vaccine.2019.02.077. [Epub ahead of print]
Caregiver's attitudes, beliefs, and experiences for influenza vaccination in Australian children with medical comorbidities.
Norman DA1, Danchin M2, Van Buynder P3, Moore HC4, Blyth CC5, Seale H6.
Author information
Abstract
BACKGROUND:
Influenza vaccination is recommended and funded for Australian children with medical comorbidities that increase their risk of severe influenza. Despite this, influenza vaccine coverage remains low within this population. We examined caregivers' attitudes and practices for influenza vaccination in children with medical comorbidities.
METHODS:
Cross-sectional surveys were conducted with caregivers of children (6 months to <18 years old) with medical comorbidities attending sub-speciality paediatric outpatient clinics at the Royal Children's Hospital (Melbourne), Princess Margaret Hospital (Perth), and Leading Steps private paediatric clinic (Gold Coast). Multivariate linear regression was used to identify surveys responses predictive of receipt of influenza vaccination in 2017.
RESULTS:
From the 611 surveys collected, 556 were suitable for analysis. Caregiver reported 2017 influenza vaccine coverage was 52.2% in children with medical comorbidities. Caregivers who believed influenza vaccines to be ≥50% effective were more likely to vaccinate their children (adjusted Odds Ratio [aOR]:3.79 (2.41; 5.96). Those who expressed concerns about vaccine side effects were less likely to vaccinate their children (aOR: 0.49 [95% CI: 0.30; 0.80]). Influenza vaccine uptake was significantly more likely for children who had been previously recommended influenza vaccination by their hospital-based physician (aOR: 4.33 [95% CI: 2.58; 7.27]) and had previously received a hospital-based vaccination (aOR: 3.11 [95% CI 1.79; 5.40]). Hospital-based physicians were also caregivers' most commonly reported source of trusted vaccination information (63.5%). Whilst only 29.3% of caregivers reported their child had been recommended influenza vaccination during a previous admission, 80.1% of caregivers stated they were receptive to their child receiving potential future influenza vaccinations during hospitalisations.
CONCLUSIONS:
Reported influenza vaccination coverage in children with medical comorbidities remains inadequate. An important finding of this study is that influenza vaccination recommendation by children's hospital physicians and previous vaccine receipt in hospital was associated with vaccine uptake. Opportunities for vaccination, especially during hospitalisation, must be examined.
Copyright © 2019 Elsevier Ltd. All rights reserved.
KEYWORDS:
Children; Influenza vaccine; Medical comorbidity; Survey
PMID: 30885511 DOI: 10.1016/j.vaccine.2019.02.077
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Vaccine. 2019 Mar 15. pii: S0264-410X(19)30314-7. doi: 10.1016/j.vaccine.2019.03.009. [Epub ahead of print]
Efficacy of novel recombinant fowlpox vaccine against recent Mexican H7N3 highly pathogenic avian influenza virus.
Criado MF1, Bertran K2, Lee DH3, Killmaster L4, Stephens CB5, Spackman E6, Sa E Silva M7, Atkins E8, Mebatsion T9, Widener J10, Pritchard N11, King H12, Swayne DE13.
Author information
Abstract
Since 2012, H7N3 highly pathogenic avian influenza (HPAI) has produced negative economic and animal welfare impacts...Yesterday, 02:27 AM -
Antiviral Res. 2019 Mar 15. pii: S0166-3542(18)30659-4. doi: 10.1016/j.antiviral.2019.03.003. [Epub ahead of print]
Potent and broad-spectrum cycloheptathiophene-3-carboxamide compounds that target the PA-PB1 interaction of influenza virus RNA polymerase and possess a high barrier to drug resistance.
Nannetti G1, Massari S2, Mercorelli B1, Bertagnin C1, Desantis J2, Palù G1, Tabarrini O2, Loregian A3.
Author information
Abstract
Influenza viruses are major respiratory pathogens responsible for both seasonal epidemics and occasional...Yesterday, 02:26 AM -
CMAJ. 2019 Mar 18;191(11):E313. doi: 10.1503/cmaj.181477.
High-dose influenza vaccination.
Dalcin D1, Kwong JC2.
Author information
PMID: 30885970 DOI: 10.1503/cmaj.181477
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Nat Microbiol. 2019 Mar 18. doi: 10.1038/s41564-019-0392-y. [Epub ahead of print]
Antibody responses to viral infections: a structural perspective across three different enveloped viruses.
Murin CD1, Wilson IA1,2,3, Ward AB4,5.
Author information
Abstract
Antibodies serve as critical barriers to viral infection. Humoral immunity to a virus is achieved through the dual role of antibodies in communicating the presence of invading pathogens in infected cells to effector cells, and in interfering with processes...Yesterday, 02:24 AM -
Future Med Chem. 2019 Mar 19. doi: 10.4155/fmc-2018-0397. [Epub ahead of print]
Discovery of novel anti-influenza agents via contemporary medicinal chemistry strategies (2014-2018 update).
Jia R1, Zhang J1, Ju H1, Kang D1, Fang Z2, Liu X1, Zhan P1.
Author information
KEYWORDS:
drug design; influenza; medicinal chemistry
PMID: 30887815 DOI: 10.4155/fmc-2018-0397
...Yesterday, 02:23 AM -
Curr Opin Infect Dis. 2019 Mar 18. doi: 10.1097/QCO.0000000000000538. [Epub ahead of print]
A delicate balancing act: immunity and immunopathology in human H7N9 influenza virus infections.
Karawita AC1, Tong MZW1, Short KR1,2.
Author information
Abstract
PURPOSE OF REVIEW:
A delicate balance exists between a protective and detrimental immune response to an invading viral pathogen. Here, we review the latest advancements in our understanding of immunity and immunopathology during H7N9 influenza A virus (IAV) infections...Yesterday, 02:22 AM
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