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Pire saison de la grippe de l’histoire récente La province, dont Québec, peine à se débarrasser de l’influenza Valérie Bidégaré Vendredi, 24 mars 2017 20:20 MISE à JOUR Vendredi, 24 mars 2017 20:25 Le Québec est frappé de plein fouet par la pire saison de la grippe de l’histoire récente, selon le Dr Guy Boivin, microbiologiste et infectiologue au CHU de Québec. «De mémoire...Today, 09:20 AM
Worst Flu Season in Recent History
The province, including Quebec, is struggling to get rid of influenza Valérie Bidégaré Friday, 24 March 2017 20:20 UPDATE Friday, 24 March 2017 20:25 Quebec is hit hard by the worst flu season in recent history, according to Dr. Guy Boivin, a microbiologist and infectious disease researcher at the Quebec university hospital. "From memory, this is the first time ...Today, 09:18 AM
Baseline Prevalence of Birth Defects Associated with Congenital Zika Virus Infection — Massachusetts, North Carolina, and Atlanta, Georgia, 2013–2014Baseline Prevalence of Birth Defects Associated with Congenital Zika Virus Infection — Massachusetts, North Carolina, and Atlanta, Georgia, 2013–2014
Weekly / March 3, 2017 / 66(8);219–222
Janet D. Cragan, MD1; Cara T. Mai, DrPH1; Emily E. Petersen, MD2; Rebecca F. Liberman, MPH3; Nina E. Forestieri, MPH4; Alissa C. Stevens, MPH5; Augustina Delaney, PhD1; April L. Dawson, MPH1; Sascha R. Ellington, MSPH2; Carrie K. Shapiro-Mendoza, PhD2; Julie E. Dunn, PhD3; Cathleen A. Higgins3; Robert E. Meyer, PhD4; Tonya Williams, PhD5; Kara N.D. Polen, MPH1; Kim Newsome, MPH1; Megan Reynolds, MPH1; Jennifer Isenburg, MSPH1; Suzanne M. Gilboa, PhD1; Dana M. Meaney-Delman, MD6; Cynthia A. Moore, MD, PhD1; Coleen A. Boyle, PhD7; Margaret A. Honein, PhD1 (View author affiliations)
Zika virus infection during pregnancy can cause serious brain abnormalities, but the full range of adverse outcomes is unknown (1). To better understand the impact of birth defects resulting from Zika virus infection, the CDC surveillance case definition established in 2016 for birth defects potentially related to Zika virus infection* (2) was retrospectively applied to population-based birth defects surveillance data collected during 2013–2014 in three areas before the introduction of Zika virus (the pre-Zika years) into the World Health Organization’s Region of the Americas (Americas) (3). These data, from Massachusetts (2013), North Carolina (2013), and Atlanta, Georgia (2013–2014), included 747 infants and fetuses with one or more of the birth defects meeting the case definition (pre-Zika prevalence = 2.86 per 1,000 live births). Brain abnormalities or microcephaly were the most frequently recorded (1.50 per 1,000), followed by neural tube defects and other early brain malformations† (0.88), eye abnormalities without mention of a brain abnormality (0.31), and other consequences of central nervous system (CNS) dysfunction without mention of brain or eye abnormalities (0.17). During January 15–September 22, 2016, the U.S. Zika Pregnancy Registry (USZPR) reported 26 infants and fetuses with these same defects among 442 completed pregnancies (58.8 per 1,000) born to mothers with laboratory evidence of possible Zika virus infection during pregnancy (2). Although the ascertainment methods differed, this finding was approximately 20 times higher than the proportion of one or more of the same birth defects among pregnancies during the pre-Zika years. These data demonstrate the importance of population-based surveillance for interpreting data about birth defects potentially related to Zika virus infection.
Statewide data from birth defects surveillance programs in Massachusetts and North Carolina for 2013 and from a surveillance program in three counties in metropolitan Atlanta, Georgia, for 2013–2014 were chosen for analysis because these programs conducted population-based surveillance for all types of birth defects, used active multisource case-finding, and were rapidly able to provide individual-level data with sufficient detail to apply all inclusion and exclusion criteria (4). Trained staff members in these surveillance programs routinely reviewed the medical records of infants and fetuses with birth defects and abstracted information about those defects, related diagnostic procedures, and demographic and pregnancy information. Included were all infants and fetuses who were identified through surveillance with a birth defect characterized by CDC subject matter experts as being consistent with those observed in cases of congenital Zika virus infection (2). Additional data collected included the pregnancy outcome (live birth or pregnancy loss), maternal age, gestational age at delivery, and verbatim clinical descriptions of all birth defects, including genetic abnormalities. These verbatim descriptions were reviewed by CDC subject matter experts to verify the case definition and categorization. The earliest age that a birth defect meeting the definition was noted (i.e., prenatally, ≤28 days after delivery, 29 days to <3 months after delivery, ≥3 to <6 months after delivery, and ≥6 months after delivery) was available for data from Massachusetts and Atlanta.
Infants or fetuses with birth defects were aggregated into four mutually exclusive categories of defects characterized by CDC subject matter experts as being consistent with those observed with congenital Zika virus infection: 1) brain abnormalities or microcephaly (head circumference at delivery <3rd percentile for sex and gestational age) (5); 2) neural tube defects and other early brain malformations; 3) eye abnormalities without mention of a brain abnormality included in the first two categories; and 4) other consequences of CNS dysfunction, specifically joint contractures and congenital sensorineural deafness, without mention of brain or eye abnormalities included in another category. Baseline prevalence per 1,000 live births (6) and 95% confidence intervals (CIs) were estimated using Poisson regression.
The three birth defects surveillance programs identified 747 infants and fetuses during 2013 (North Carolina and Massachusetts) and 2013–2014 (Atlanta) with one or more defects that met the 2016 CDC Zika surveillance case definition (2.86 per 1,000 live births [CI = 2.65–3.07]) (Table). Brain abnormalities or microcephaly accounted for the largest number (392 [52%]) and highest prevalence (1.50 per 1,000), followed by neural tube defects and other early brain malformations (229 [31%]; 0.88). Eye abnormalities without mention of a brain abnormality (81 [11%]; 0.31) and consequences of CNS dysfunction without mention of brain or eye abnormalities (45 [6%]; 0.17) were less frequent. Pregnancy losses (48%) and preterm delivery (<37 weeks’ gestation) (66%) occurred most frequently with neural tube defects and other early brain malformations. In contrast, all infants with eye abnormalities without mention of a brain abnormality were liveborn.
In general, the distribution by maternal age was similar across birth defect categories. Among 410 (55%) infants or fetuses with information on the earliest age a birth defect was recorded, 371 (90%) had evidence of a birth defect meeting the Zika definition before age 3 months. More than half of those with brain abnormalities or microcephaly or with neural tube defects and other early brain malformations had evidence of these defects noted prenatally (55% and 89%, respectively).
A congenital Zika syndrome phenotype has been described (7); however, the birth defects observed are not unique to congenital Zika virus infection, and the full range of effects of congenital Zika infection is not known. The data in this report provide a baseline reference for the prevalence of defects observed with congenital Zika virus infection in the pre-Zika years and demonstrate the importance of data on birth defects prevalence in providing a context within which to assess the impact of teratogenic exposures such as Zika virus infection. Recently published data from the USZPR reported 26 infants and fetuses with these same birth defects among 442 completed pregnancies with laboratory evidence of Zika virus infection during a 9-month period in 2016. This proportion (58.8 per 1,000) is approximately 20 times higher than the prevalence (2.86 per 1,000) from the three population-based birth defects surveillance programs during the pre-Zika years. In addition, of the 26 USZPR infants and fetuses, 22 had a brain abnormality or microcephaly (2). This proportion (49.8 per 1,000; CI = 33.1–74.8) is approximately 33 times higher than the prevalence (1.5 per 1,000) among pregnancies in the pre-Zika years.
A recently published report from New York took a somewhat different approach to establishing a pre-Zika baseline for congenital birth defects. It examined diagnoses of microcephaly, but not other defects, for the period 2013–2015 and found that, before evidence of importation of Zika virus infections, the overall prevalence of microcephaly in New York was 7.4 per 10,000 live births (0.74 per 1,000), and the prevalence of severe congenital microcephaly (newborn head circumference <3rd percentile for sex and gestational age) was 4.2 per 10,000 (0.42 per 1,000) (8).
The findings in this report are subject to at least six limitations. First, population-based surveillance programs strive to ascertain the prevalence of birth defects among all members of a specified population. In contrast, the aim of USZPR is to estimate the proportion of birth defects among pregnancies with laboratory evidence of possible Zika virus infection, a specific subgroup of the general population (2). This could lead to selection bias with USZPR if, for example, pregnancies with fetal abnormalities detected prenatally...Today, 05:33 AM
Meningococcal disease – Nigeria
Disease outbreak news 24 March 2017 As of 19 March 2017 (epidemiological week 11), a total of 1407 suspected cases of meningitis and 211 deaths (case fatality rate: 15%) have been reported from 40 local gov...Yesterday, 07:10 PM
Scare in Naivasha as residents wake up to dead chickens dumped by the road
By Antony Gitonga
| Updated Thu, March 16th 2017 at 11:58 GMT
NAIVASHA, KENYA: There was a moment of scare in Naivasha after unknown people strategically dumped tens of dead chicken along...Yesterday, 06:18 PM
Source: http://outbreaknewstoday.com/switzer...th-since-2009/ Switzerland reports 1st measles death since 2009 by Robert Herriman March 25, 2017 Health officials in Switzerland are reporting a measles fatality in a young man who had leukemia in February. This is the first measles de...Yesterday, 05:33 PM
Possible Bird Flu Case Found In Menlo News - Local News Friday, 24 March 2017 22:43 The Summerville News on Friday Department of Agriculture specialists are investigating a possible case of avian influenza at a commercial poultr...Yesterday, 02:28 PM
10296 suspected cases (10296 in Central and South America, 0 in the Caribbean, 0 in North America), 2281 confirmed cases (11 North America, 5 Caribbean, 2265 Central and South America) (2275 autochthonous transmission and 6 travel related imported cases)...Yesterday, 10:22 AM
1479 outbreaks with 481064 cases of H5N8 ins waterfowl, wild birds and poultry reported by OIE in Europe as of 24 March...Yesterday, 10:14 AM
821 suspected cases (752 clinical suspected/69 suspected without diagnosis))/ 3 confirmed cases; 25 neurological cases (including 10 cases of GBS and 1 case of multiple sclerosis), 9 cases of microcephaly/cases of cognitive malformations (total: 135...Yesterday, 09:10 AM
Govt reveals one Zika virus case detected in Ahmedabad Fri, 17 Mar 2017-09:41pm , PTI Minister of State for Health Anupriya Patel said Zika virus is widely prevalent in India. Only one case of Zika virus has been detected in Ahmedabad in January and a detailed surveillance thereafter has not shown any other positive ca...Yesterday, 04:15 AM
Construction of recombinant fusion protein of influenza, a virus neuraminidase and heat shock protein 70 gene: expression in baculovirus and bioactivityJ Med Life. 2015;8(Spec Iss 4):189-195.
Construction of recombinant fusion protein of influenza, a virus neuraminidase and heat shock protein 70 gene: expression in baculovirus and bioactivity.
Moghaddam Pour M1, Keivani H2, Masoudi SH3, Monavari SH2, Najafi M4.
...Yesterday, 03:06 AM
Estimates of hospitalization attributable to influenza and RSV in the US during 1997-2009, by age and risk statusBMC Public Health. 2017 Mar 21;17(1):271. doi: 10.1186/s12889-017-4177-z.
Estimates of hospitalization attributable to influenza and RSV in the US during 1997-2009, by age and risk status.
Matias G1, Taylor R2, Haguinet F3, Schuck-Paim C2, Lustig R2, Shinde V4,5.
Estimates of influenza and respiratory syncytial virus (RSV) burden must be periodically updated to inform public health strategies. We estimated seasonal influenza- and RSV-attributable hospitalizations in the US from 1997 to 2009 according to age and risk status (NCT01599390).
Multiple linear regression modelling was used to attribute hospitalizations to influenza or RSV using virological surveillance and hospitalization data. Hospitalization data were obtained from the US Nationwide Inpatient Sample and virology data were obtained from FluView (Centers for Disease Control and Prevention). Outcomes included any mention of ICD-coded respiratory disease and cardiorespiratory disease diagnoses. We also explored a broader definition of respiratory disease that included mention of relevant respiratory sign/symptoms and viral infection ("respiratory broad").
Applying the respiratory broad outcome, our model attributed ~300,000 and ~200,000 hospitalizations to influenza and RSV, respectively. Influenza A/H3N2 was the predominant cause of influenza-related hospitalizations in most seasons, except in three seasons when influenza B was dominant; likewise, A/H3N2 caused most influenza-related hospitalizations in all age segments, except in children ...Yesterday, 03:04 AM
BMC Nephrol. 2017 Mar 20;18(1):96. doi: 10.1186/s12882-017-0512-y.
Case report - atypical hemolytic uremic syndrome triggered by influenza B.
Kobbe R1, Schild R2, Christner M2, Oh J2, Loos S2, Kemper MJ2.
Influenza A infections have been described...Yesterday, 03:03 AM
Facilitators and barriers of parental attitudes and beliefs toward school-located influenza vaccination in the United States: Systematic reviewVaccine. 2017 Mar 17. pii: S0264-410X(17)30320-1. doi: 10.1016/j.vaccine.2017.03.014. [Epub ahead of print]
Facilitators and barriers of parental attitudes and beliefs toward school-located influenza vaccination in the United States: Systematic review.
Kang GJ1, Culp RK1, Abbas KM2.
...Yesterday, 03:02 AM
J Vet Med Sci. 2017 Mar 19. doi: 10.1292/jvms.17-0052. [Epub ahead of print]
Influenza A virus infection in Japanese wild boars (Sus scrofa leucomystax).
Shimoda H1, VAN Nguyen D, Yonemitsu K, Minami S, Nagata N, Hara N, Kuwata R, Murakami S, Kodera Y, Takeda T, Yoshikawa Y, Horimoto T, Maeda...Yesterday, 03:00 AM
Recombinant Lactococcus lactis Expressing Haemagglutinin from a Polish Avian H5N1 Isolate and Its Immunological Effect in Preliminary Animal TrialsBiomed Res Int. 2017;2017:6747482. doi: 10.1155/2017/6747482. Epub 2017 Feb 22.
Recombinant Lactococcus lactis Expressing Haemagglutinin from a Polish Avian H5N1 Isolate and Its Immunological Effect in Preliminary Animal Trials.
Szczepankowska AK1, Szatraj K1, Sałański P1, Rózga A1, Górecki...Yesterday, 02:59 AM
Poly-γ-glutamic acid/chitosan nanogel greatly enhances the efficacy and heterosubtypic cross-reactivity of H1N1 pandemic influenza vaccineSci Rep. 2017 Mar 21;7:44839. doi: 10.1038/srep44839.
Poly-γ-glutamic acid/chitosan nanogel greatly enhances the efficacy and heterosubtypic cross-reactivity of H1N1 pandemic influenza vaccine.
Yang J1, Shim SM2,3, Nguyen TQ1,4, Kim EH2,5, Kim K6, Lim YT7, Sung MH6,8, Webby R9, Poo H1,2,...Yesterday, 02:58 AM
Multiplex Reverse-Transcription Loop-Mediated Isothermal Amplification Coupled with Cascade Invasive Reaction and Nanoparticle Hybridization for Subtyping of Influenza A VirusSci Rep. 2017 Mar 21;7:44924. doi: 10.1038/srep44924.
Multiplex Reverse-Transcription Loop-Mediated Isothermal Amplification Coupled with Cascade Invasive Reaction and Nanoparticle Hybridization for Subtyping of Influenza A Virus.
Chi Y1,2, Ge Y2, Zhao K2, Zou B3, Liu B4, Qi X2, Bian Q2,...Yesterday, 02:57 AM
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