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J Virol. Pathogenesis, transmissibility, and ocular tropism of a highly pathogenic avian influenza A (H7N3) virus associated with human conjunctivitis.

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  • J Virol. Pathogenesis, transmissibility, and ocular tropism of a highly pathogenic avian influenza A (H7N3) virus associated with human conjunctivitis.

    [Source: US National Library of Medicine, full text: (LINK). Abstract, edited.]
    J Virol. 2013 Mar 13. [Epub ahead of print]

    Pathogenesis, transmissibility, and ocular tropism of a highly pathogenic avian influenza A (H7N3) virus associated with human conjunctivitis.


    Belser JA, Davis CT, Balish A, Edwards LE, Zeng H, Maines TR, Gustin KM, MartÝnez IL, Fasce R, Cox NJ, Katz JM, Tumpey TM.

    Source: Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333.



    Abstract

    H7 subtype influenza A viruses, responsible for numerous outbreaks in land-based poultry in Europe and the Americas, have caused over 100 cases of confirmed or presumed human infection over the last decade. The emergence of a highly pathogenic avian influenza H7N3 virus in poultry throughout the state of Jalisco, Mexico, resulting in two cases of human infection, prompted us to examine the virulence of this virus [A/Mexico/InDRE7218/2012 (MX/7218)] and related avian H7 subtype viruses in mouse and ferret models. Several high and low pathogenicity H7N3 and H7N9 viruses replicated efficiently in the respiratory tract of mice without prior adaptation following intranasal inoculation, but only MX/7218 virus caused lethal disease in this species. H7N3 and H7N9 viruses were also detected in the mouse eye following ocular inoculation. Virus from both H7N3 and H7N9 subtypes replicated efficiently in the upper and lower respiratory tract of ferrets, however, only MX/7218 virus infection caused clinical signs and symptoms and was capable of transmission to na´ve ferrets in a direct contact model. Similar to other highly pathogenic H7 viruses, MX/7218 replicated to high titers in human bronchial epithelial cells, yet downregulated numerous genes related to NF-κB-mediated signaling transduction. These findings indicate that the recently isolated North American lineage H7 subtype virus associated with human conjunctivitis is capable of causing severe disease in mice and spreading to na´ve contact ferrets, while concurrently retaining the ability to replicate within ocular tissue allowing the eye to serve as a portal of entry.


    PMID: 23487452 [PubMed - as supplied by publisher]
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  • #2
    Re: J Virol. Pathogenesis, transmissibility, and ocular tropism of a highly pathogenic avian influenza A (H7N3) virus associated with human conjunctivitis.

    7,3,6,-,4,-,2,3 amino acids away from the bird-index
    NL/2003(H7N7) was closer with 2,1,4,-,3,-,2,3
    CDN/2004(H7N3) was 3,4,9,-,3,1,2
    1918 flu had 8,7,10,-,9,-,7,5
    and Qinghai H5N1 was 9,8,10,-7,-14,18

    closest neighbors in the 8 segments:

    Code:
     135   31 2280 7410 >A/mallard/California/198/2012,2012/01/07,H11N9
     140   32 2280 6323 >A/northern pintail/California/3466/2010,2010/12/08,H1N3
     140   32 2280 7413 >A/mallard/California/3569/2010,2010/12/18,H1N3
    
      57   13 2274 7345 >A/American green-winged teal/Mississippi/11OS98/2011,2011/01/08,mixed
      92   21 2274 7383 >A/American green-winged teal/Wisconsin/10OS3127/2010,2010/10/20,H5N2
      92   21 2274 7528 >A/bufflehead/California/3118/2011,2011/12/07,H4N8
      92   21 2274 7530 >A/green-winged teal/California/123/2012,2012/01/07,H1N1
     105   24 2274 6459 >A/mallard/California/2396/2010,2010/10/30,H5N2
     114   26 2274 7484 >A/mallard/California/2535P/2011,2011/08/12,H5N1
    
     120   26 2151 8662 >A/green-winged teal/California/123/2012,2012/01/07,H1N1
     134   29 2151 6871 >A/mallard/Alberta/115/2007,2007/08/22,mixed
     167   36 2151 6391 >A/American green-winged teal/Mississippi/300/2010,2010/01/16,H11N9
    
      94   16 1688 1110 >A/American black duck/Wisconsin/10OS3949/2010,2010/11/18,H7N8
     100   17 1688 1098 >A/mallard/Missouri/10MO0551/2010,2010/12/29,H7N7
     100   17 1688 1102 >A/northern shoveler/Arkansas/11OS333/2011,2011/01/12,H7
     106   18 1688 1116 >A/northern shoveler/Missouri/10OS4750/2010,2010/12/12,H7N3
     106   18 1688 1117 >A/northern shoverl/Mississippi/11OS145/2011,2011/01/08,H7N9
     112   19 1688 1118 >A/American green-winged teal/Mississippi/11OS247/2011,2011/01/15,H7
    
      80   12 1497 8356 >A/American green-winged teal/Mississippi/11OS259/2011,2011/01/15,mixed
      86   13 1497 8323 >A/mallard/Iowa/10OS2721/2010,2010/10/16,H2N2
      86   13 1497 8324 >A/American wigeon/Iowa/10OS2748/2010,2010/10/17,H2N2
      86   13 1497 8331 >A/mallard/Illinois/10OS4179/2010,2010/11/29,H11N2
      93   14 1497 8219 >A/mallard/California/2525V/2011,2011/08/12,mixed
      93   14 1497 8347 >A/American green-winged teal/Mississippi/11OS90/2011,2011/01/08,H11N9
      93   14 1497 8384 >A/mallard/California/2525P/2011,2011/08/12,H4N6
    
     276   39 1410  600 >A/American green-winged teal/Illinois/10OS3343/2010,2010/10/30,H2N3
     297   42 1410  437 >A/mallard/Wisconsin/2560/2009,2009/10/05,H2N3
     304   43 1410  431 >A/blue-winged teal/Wisconsin/2572/2009,2009/10/06,H2N3
    
     112   11  982 8119 >A/mallard/Ohio/11OS2239/2011,2011/08/19,H5N2
     122   12  982 8073 >A/mallard/Ohio/11OS2237/2011,2011/08/19,mixed
    
      83    7  838 6536 >A/mallard/Illinois/10OS3786/2010,2010/11/27,H10N7
     107    9  838 5851 >A/northern shoveler/California/3183/2010,2010/11/27,H11N2
     107    9  838 6588 >A/northern shoveler/Missouri/10OS4718/2010,2010/12/12,H10N7
    I'm interested in expert panflu damage estimates
    my current links: [url]http://bit.ly/hFI7H[/url] ILI-charts: [url]http://bit.ly/CcRgT[/url]

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