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South China Agricultural University finds pangolin? as a potential intermediate host for new coronavirus - WHO says: the route of transmission to humans at the start of this event remains unclear.

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  • South China Agricultural University finds pangolin? as a potential intermediate host for new coronavirus - WHO says: the route of transmission to humans at the start of this event remains unclear.

    Translation Google

    South China Agricultural University finds pangolin as a potential intermediate host for a new coronavirus

    Review and release: Chen Chenchen, the propaganda department Source unit and reviewer: Yang Zhiqun, propaganda department Time: 2020-02-07 Views: 5114

    The latest research conducted by South China Agricultural University, Lingnan Modern Agricultural Science and Technology Guangdong Provincial Laboratory, Professor Shen Yongyi, and Professor Xiao Lihua, together with Researcher Yang Ruiyu from the Military Medical Research Institute of the Chinese Academy of Military Sciences and Chen Wu Senior Veterinarian of the Guangzhou Zoo Research Department, shows Pangolin is a potential intermediate host for a new coronavirus. This latest discovery will have great significance for the prevention and control of the origin of the new coronavirus.

    https://www.scau.edu.cn/2020/0207/c1300a219015/page.htm
    "Safety and security don't just happen, they are the result of collective consensus and public investment. We owe our children, the most vulnerable citizens in our society, a life free of violence and fear."
    -Nelson Mandela

  • #2
    Pangolins are in high demand in countries like China and Vietnam. Their meat is considered a delicacy and pangolin scales are used in traditional medicine and folk remedies to treat a range of ailments from asthma to rheumatism and arthritis. All eight pangolin species are protected under national and international laws but that is not stopping the massive international illegal trade in pangolins, which has increased in recent years because of growing demand.

    https://www.worldwildlife.org/species/pangolin

    Comment


    • #3
      Translation Google

      Huanong: 99% similarity between strains isolated from pangolins and new crowns

      2020-02-07 11 : 16Source: Southern NetworkWu Shaomin Zhong Zhe

        Southern Network News At 11 am on the 7th, South China Agricultural University held a press conference on the research of the new coronavirus pneumonia epidemic situation.

        The reporter was informed at the press conference that South China Agricultural University, Lingnan Modern Agricultural Science and Technology Guangdong Laboratory Professor Shen Yongyi, Xiao Lihua and other scientific researchers, through joint research, have made breakthroughs in the traceability of potential intermediate hosts of new coronaviruses. Their latest research suggests that pangolin is a potential intermediate host for a new coronavirus.

        It is understood that the research team identified more than 1,000 metagenomic samples and identified pangolins as potential intermediate hosts of the new coronavirus; then, through molecular biology tests, revealed that the positive rate of beta coronavirus in pangolins was 70%; further isolate the virus Identification, the typical coronavirus particle structure was observed under the electron microscope; finally, by analyzing the virus genome, it was found that the sequence similarity between the isolated virus strain and the currently infected human strain was as high as 99%.

        The above results indicate that pangolin is a potential intermediate host for a new coronavirus. The research results are of great significance to the source prevention and control of the epidemic, and provide a scientific basis for the adjustment of related policies for wildlife control.

        "Given the seriousness of the current epidemic prevention and control, we choose to publish the research results to the society as soon as possible, hoping to contribute to the scientific prevention and control of the epidemic and provide reference for more scientists to carry out further work." Introduction of Professor Liu Yahong, Executive Deputy Director of Guangdong Laboratory of Technology and President of South China Agricultural University, at the beginning of the outbreak of the new-CoV coronavirus in 2019-Guangdong Province And South China Agricultural University attaches great importance. Under the guidance of various government departments in Guangdong Province, with the support of the new Coronavirus epidemic prevention and control science and technology emergency response project of the Guangdong Provincial Department of Agriculture and Rural Affairs, the school's superior discipline platform was integrated, and the school's superior scientific research force was launched to carry out joint epidemic prevention and control. Made a major breakthrough.

        Liu Yahong said that South China Agricultural University has long adhered to the national and people's interests as the top priority, insisted that scientific research be in the forefront, and called on the school's scientific researchers to write thesis on the motherland. At present, schools are responding more actively to national calls, reflecting responsibility and responsibility, and writing dissertations on the front line of epidemic prevention and control. The school will use the strength of the whole school to give full play to the advantages of Lingnan's modern agricultural Guangdong laboratory and other platforms, take the initiative and take the initiative to pay close attention to the possible impact of new coronavirus on China's livestock and poultry industry and agricultural production, and strengthen major animal diseases and animals. Surveillance and research of zoonotic diseases has provided scientific and technological support for epidemic prevention and control and the steady development of China's livestock and poultry industry, and contributed scientific and technological strength to win the fight against epidemic prevention and control.

        [Nanfang Daily Reporter] Wu Shaomin and Zhong Zhe

      http://news.southcn.com/nfplus/gdjkt...6359761204.0.0
      "Safety and security don't just happen, they are the result of collective consensus and public investment. We owe our children, the most vulnerable citizens in our society, a life free of violence and fear."
      -Nelson Mandela

      Comment


      • #4
        " Their meat is considered a delicacy and pangolin scales are used in traditional medicine and folk remedies to treat a range of ailments from asthma to rheumatism and arthritis. All eight pangolin species are protected under national and international laws but that is not stopping the massive international illegal trade in pangolins, which has increased in recent years because of growing demand."
        https://www.worldwildlife.org/species/pangolin

        utilisées dans la médecine traditionnelle et les remèdes populaires,
        used in traditional medicine and folk remedies

        Par respect pour la médecine traditionnelle,et pour l'immense travail , fait en Chine, sur sa phamacopée, un texte permettant d'entrevoir la signification actuelle de ces deux acceptions serait un plus ...

        Comment


        • #5
          they had been traded on the Wuhan seafood market
          I'm interested in expert panflu damage estimates
          my current links: [url]http://bit.ly/hFI7H[/url] ILI-charts: [url]http://bit.ly/CcRgT[/url]

          Comment


          • #6
            Par respect, on doit évoquer les marchés globaux ...

            Lors de la fermeture de ce marché, et de bien d'autres, si certains étaient présent, ils ont du être saisis:
            A massive win for the world’s most trafficked mammal
            https://www.worldwildlife.org/storie...fficked-mammal

            Vu la protection prévue par la loi, ils n'ont pas du être euthanasiés. Les faits publiés, indiquent que les lieux et conditions de détention doivent les avoir préoccupé.

            Par courtoisie, il me semble nécessaire de les laisser publier à leur rythme... Si la première des préoccupations ce doit être l'humain, savoir que pour la part animale, ils ont fait, font et ferons est rassurant.


            - On sait quoi des animaux détenus dans les zoos, etc, aux U.S.A et ailleurs ?
            - On fait quoi pour éviter leur contamination ou re-contamination ?

            Comment


            • #7
              En parcs zoologiques en Europe, seul le zoo de Leipzig en Allemagne présente cette espèce singulière.
              https://zoospassion.com/Classificati...euecourte.html

              vu ceci:
              The journal Frontiers in Ecology & the Environment estimated that the remains of about 10,000 pangolins are intercepted each year.[15] Zhao-Min Zhou and Macdonald from Frontiers in Ecology & the Environment claim from their records that 220 living pangolins and the remains of 4,909 dead pangolins were seized in 43 law enforcement actions since 2010.[14]

              The Indonesian Forestry Ministry director of investigations and forest observation, Raffles Panjaitan, told the Jakarta Post that in October 2011, his agency had 587 cases of pangolin trafficking since 2006. The estimated value is US$4.3 million worth of pangolins on the illegal market.[14]

              In April 2013, a Philippine coast guard inspected a boat where they found 22,000 lb (10,000 kg) of pangolin meat. They also discovered 400 boxes containing thousands of frozen skinned pangolins and scaly anteaters from Indonesia. The Regional Trial Court in Puerto Princesa city in Palawan province sentenced the boat captain to 12 years in prison and each crew member received from six to 10 years. Each member of the crew was also fined $100,000.[15]

              https://en.wikipedia.org/wiki/Chinese_pangolin

              Si j'ai confiance, dans les actions faites en Chine, il se passe quoi dans les autres pays évoqués ?

              Comment


              • #8
                nCoV-2019 Spike Protein Receptor Binding Domain Shares High Amino Acid Identity With a Coronavirus Recovered from a Pangolin Viral Metagenomic Dataset

                jan 30, 2020

                An outbreak of respiratory illness caused by a novel coronavirus (nCoV-2019, NC_045512.2 52) first identified in Wuhan China has resulted in over seven thousand confirmed cases.

                So far, the nCoV-2019 has been reported to share 96% sequence identity to the RaTG13 genome (EPI_ISL_402131). However, the S1 Receptor Binding Domain (RBD) of the nCoV-2019 genome was noticeably divergent between the two at amino acid residues 350 to 550 – Figure 1A.

                We aimed to identity coronaviruses related to nCoV-2019 in viral metagenomics datasets available in the public domain. In a recently published dataset describing viral diversity in Malayan pangolins (PRJNA573298 134) we used VirMAP 48 to reconstruct a coronavirus genome (approximately 84% complete from samples SRR10168377 41 and SRR10168378 23) that shared 97% amino acid identity across the same RBD segment – Figure 1B. This result indicates a potential recombination event for nCoV-2019.

                Edit -
                From the coordinates shown in this preprint 177 (Figure 4), it looks like most of the differences between RaTG13 and nCoV-2019 are restricted to loop 2 of the receptor binding motif (positions ~450-500).

                An outbreak of respiratory illness caused by a novel coronavirus (nCoV-2019, NC_045512.2) first identified in Wuhan China has resulted in over seven thousand confirmed cases. So far, the nCoV-2019 has been reported to sh…
                “Addressing chronic disease is an issue of human rights – that must be our call to arms"
                Richard Horton, Editor-in-Chief The Lancet

                ~~~~ Twitter:@GertvanderHoek ~~~ GertvanderHoek@gmail.com ~~~

                Comment


                • #9
                  they eat ants, are active at night. How to pick up a bat-virus (or vice versa)

                  horseshoe-bats : All species are insectivorous, capturing insects in flight
                  I'm interested in expert panflu damage estimates
                  my current links: [url]http://bit.ly/hFI7H[/url] ILI-charts: [url]http://bit.ly/CcRgT[/url]

                  Comment


                  • #10
                    Viral Metagenomics Revealed Sendai Virus and Coronavirus Infection of Malayan Pangolins (Manis javanica).

                    Liu P, et al. Viruses. 2019.
                    Show full citation Abstract

                    Pangolins are endangered animals in urgent need of protection. Identifying and cataloguing the viruses carried by pangolins is a logical approach to evaluate the range of potential pathogens and help with conservation.

                    This study provides insight into viral communities of Malayan Pangolins (Manis javanica) as well as the molecular epidemiology of dominant pathogenic viruses between Malayan Pangolin and other hosts. A total of 62,508 de novo assembled contigs were constructed, and a BLAST search revealed 3600 ones (≥300 nt) were related to viral sequences, of which 68 contigs had a high level of sequence similarity to known viruses, while dominant viruses were the Sendai virus and Coronavirus

                    . This is the first report on the viral diversity of pangolins, expanding our understanding of the virome in endangered species, and providing insight into the overall diversity of viruses that may be capable of directly or indirectly crossing over into other mammals.
                    “Addressing chronic disease is an issue of human rights – that must be our call to arms"
                    Richard Horton, Editor-in-Chief The Lancet

                    ~~~~ Twitter:@GertvanderHoek ~~~ GertvanderHoek@gmail.com ~~~

                    Comment


                    • #11
                      Apparently pangolins and scales of pangolins are of commercial interest.

                      Sars-like viruses were found in Nigeria (in bats).
                      https://www.ncbi.nlm.nih.gov/pubmed/21063474


                      Nigeria finds itself at the heart of the illegal pangolin trade

                      15 august 2019
                      • Pangolins have long been hunted for food and traditional medicine. They are traded openly in bushmeat markets in Nigeria and neighboring Cameroon.
                      • Strong demand from Asia has attracted organized criminal syndicates to set up trafficking networks in Nigeria, and the illegal trade in pangolin parts has gone deeper underground.
                      • Hunters and traders tell Mongabay that the impact of increased trafficking on pangolin populations is becoming clear as they are increasingly difficult to find in the forest.
                      • Chinese buyers will pay anywhere between $3 and $20 for a pangolin — a relative fortune for local bushmeat traders. Traffickers can then get as much as $250 for the scales from one pangolin in markets in Asia.
                      “Addressing chronic disease is an issue of human rights – that must be our call to arms"
                      Richard Horton, Editor-in-Chief The Lancet

                      ~~~~ Twitter:@GertvanderHoek ~~~ GertvanderHoek@gmail.com ~~~

                      Comment


                      • #12

                        07 FEBRUARY 2020

                        Did pangolins spread the China coronavirus to people?

                        Genetic sequences of viruses isolated from the scaly animals are 99% similar to that of the circulating virus — but the work is yet to be formally published.
                        ...
                        Scientists say that the suggestion, based on a genetic analysis, seems plausible — but caution that the researchers’ work is yet to be published in full. “This is an extremely interesting observation. Although we need to see more details, it does make sense as there are now some other data emerging that pangolins carry viruses that are closely related to 2019-nCoV,” says Edward Holmes, an evolutionary virologist at the University of Sydney, Australia.
                        ...
                        A good candidate
                        Previously, researchers have noted that coronaviruses are a possible cause of death in pangolins1, and that nCoV-2019 and coronaviruses from pangolins use receptors with similar molecular structures to infect cells.

                        Even before today’s announcement, pangolins were a good candidate for being an intermediate species for the virus, so it’s very interesting that the researchers have found such a close sequence, says David Robertson, a computational virologist at the University of Glasgow, UK.
                        ...
                        https://www.nature.com/articles/d41586-020-00364-2
                        "Safety and security don't just happen, they are the result of collective consensus and public investment. We owe our children, the most vulnerable citizens in our society, a life free of violence and fear."
                        -Nelson Mandela

                        Comment


                        • #13
                          Report linking pangolins to coronavirus lacks evidence, scientists say

                          febr 7, 2020

                          Jonathan Ball, a professor of molecular virology at Britain’s University of Nottingham, said that while the South China Agricultural University research was an interesting development, it was still unclear “whether or not the endangered pangolin really is the reservoir.”

                          “We would need to see all of the genetic data to get a feel for how related the human and pangolin viruses are, and also gain an understanding of how prevalent this virus is in pangolins and whether or not these were being sold in the Wuhan wet markets,” he said.

                          Dirk Pfeiffer, a professor of veterinary medicine at Hong Kong’s City University, also said the research was a long way from establishing a link between pangolins and the new coronavirus outbreak in humans.

                          “You can only draw more definitive conclusions if you compare prevalence [of the coronavirus] between different species based on representative samples, which these almost certainly are not,” he said.

                          Several scientists have cast doubt on a claim that pangolins may have helped pass the novel coronavirus along to humans.
                          “Addressing chronic disease is an issue of human rights – that must be our call to arms"
                          Richard Horton, Editor-in-Chief The Lancet

                          ~~~~ Twitter:@GertvanderHoek ~~~ GertvanderHoek@gmail.com ~~~

                          Comment


                          • #14
                            Il y a deux sortes de scientifiques: ceux qui produisent des faits éclairant et ceux qui cultivent le doute, surtout, pour justifier de leur fonction...

                            Comment


                            • #15

                              Hattip Shiloh

                              Novel Coronavirus(2019-nCoV)
                              Situation Report – 22

                              Data as reported by 11 February 2020*
                              ...
                              TECHNICAL FOCUS: Zoonotic component of 2019-nCoV and human-animal interface

                              Increasing evidences demonstrate the link between the 2019-nCoV and other similar known coronaviruses (CoV) circulating in bats, and more specifically those of the Rhinolophus bat sub-species. These sub-species are abundant and widely present in Southern China, and across Asia, the Middle East, Africa and Europe. Recent studies indicate that more than 500 CoVs have been identified in bats in China. To be noted that serological studies conducted in rural population living close to bats natural habitat in caves revealed a 2.9% bat-CoV seroprevalence, demonstrating that humans exposure to bat-CoVs might be common.1

                              However, the route of transmission to humans at the start of this event remains unclear. Bats are rare in markets in China but hunted and sold directly to restaurants for food.2 The current most likely hypothesis is that an intermediary host animal has played a role in the transmission.

                              Both Chinese and external expert groups are working in trying to identify the animal source of this new virus. Identifying the animal source of the 2019-nCoV would help to ensure that there will be no further future similar outbreaks with the same virus and will also help understanding the initial spread of the disease in the Wuhan area. It would also increase our understanding of the virus and help us understand how these viruses jump from animals to humans. Thus, providing critical knowledge on how to protect us from future similar events. In this regard, strengthening food control and market hygiene activities in live food market will be essential to protect people from similar and other zoonotic diseases.

                              ...
                              https://www.who.int/docs/default-sou...rsn=fb6d49b1_2
                              "Safety and security don't just happen, they are the result of collective consensus and public investment. We owe our children, the most vulnerable citizens in our society, a life free of violence and fear."
                              -Nelson Mandela

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