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Discussion thread VI - COVID-19 (new coronavirus)

new potentially dangerous variant
C.1.2

https://twitter.com/mvankerkhove/sta...03717018603529
To date there are ~100 sequences of C.1.2 reported globally, the earliest
reports from May ‘21 from South Africa.

4 of these at cog_uk, from 2021-06-21,2021-06-27,2021-07-28,2021-08-20

_lots_ of spike mutations, including these worrying ones
vaccines escapes immunity escapes
4,P9L 3,P25L 4,C136F 4,R190S
4,D215G
1,N440K 4,Y449H 1,T478K 4,E484K
4,N501Y 2,L585F
4,D614G 4,H655Y 3,N679K 1,P681H
4,T716I
4,T859N
1,D936N 1,D936H

43,42,48,41 mutations in total

here a picture from a paper from March with the concerning positions :

http://magictour.free.fr/bloom4.png
 
xhttps://www.tigerdroppings.com/rant/o-t-lounge/if-you-work-at-a-healthcare-facility-that-receives-medicare-aid-you-have-to-get-vaccinated/98236095/page-2/
re: If you work at a healthcare facility that receives medicare/aid you have to get vaccinatedPosted on 9/9/21 at 4:24 pm to athenslife101

I work in Healthcare, i had covid before vaccine was available, and now I have antibodies. I work full time in a facility that sees covid patients and I am face to face with covid patients all day, everyday. None of us have worn a mask since probably March/ April, and none of us have been reinfected. While I am not anti-vax, I am against some dipshits telling me what to do.This post was edited on 9/9 at 4:36 pm
Click to expand...

xhttps://www.tigerdroppings.com/rant/o-t-lounge/if-you-work-at-a-healthcare-facility-that-receives-medicare-aid-you-have-to-get-vaccinated/98236095/page-3/
re: If you work at a healthcare facility that receives medicare/aid you have to get vaccinatedPosted on 9/9/21 at 6:27 pm to Spankum

Got a Text from the nursing home my mother is in here in alabama. Here is the text: As you all are aware, Alabama is experiencing an extreme spike of COVID-19 cases. Covington County's current positivity rate is 22.3%. Unfortunately, Andalusia Manor is seeing an increase of VACCINATED staff that are testing positive for COVID-19. We continue to encourage residents, their loved ones, and staff to become vaccinated. If you are interested in getting the vaccine or have questions, please call the facility,

Reply stop to stop
Click to expand...
 
biweekly, England, VE in %, emergency-care
VE(EC,00-49),75,72,63,56,50
VE(EC,50-99),77,73,72,60,57

weekly average of 7 agegroups last 4 weeks :
VE(EC)=81.7,80.2
decreasing by agegroup : 87.9,86.3,84.7,81.8,72.2,64.9
 
Translation Google

When will the Covid-19 epidemic end?

Celine Deluzarche
Journalist
...
Modified on 23/09/2021
...
Don't expect a drop in virulence

One of the widespread beliefs is that the virus loses its virulence as the pandemic progresses so as not to kill its host, which is also its transmission vector. Unfortunately, this view does not stand up to the analysis of the facts, for example HIV has become more virulent over time. Likewise, the Delta variant appears to cause more severe forms than the Alpha variant. " In the case of SARS-CoV-2, severe symptoms usually appear after two weeks of infection, but more than 95% of transmissions occur before day 11. In other words, from the perspective of this coronavirus, late (particularly inflammatory) manifestations of virulence do not constitute a loss of transmission opportunities.”, says Samuel Alizon, Director of Research at the CNRS and the IRD.

Only one disease in history has been eradicated with a vaccine : smallpox , the last known case of which dates back to 1978 in the United Kingdom. “ This eradication has been possible at the cost of relentless vaccination campaigns for decades. In addition, SARS-CoV-2 has an animal reservoir, so it is almost impossible to eradicate the virus, such as the pathogen of plague, for example, ”says Eric Dortenzio, research director at Inserm. In fact, most of the viruses or bacteria responsible for past pandemics are still present today, be it plague, H1N1 or Ebola. Diseases that are still experiencing sporadic epidemic upsurges.“

Even if the virus were eradicated from the human population, it would continue to circulate in animals and could undergo unexpected mutations.

According to experts, the safest way to end an epidemic is to slow the spread of the disease and counteract its side effects.
Pest control and hygiene standards, for example, have helped control plague and cholera . Triple therapies have drastically reduced AIDS mortality . In the case of measles , vaccination makes it possible to reduce the number of contaminations to almost zero, but this requires practically 100% vaccination coverage and the immunity conferred by the vaccine to be sterilizing. that is, it prevents the transmission of the virus. Two conditions that will undoubtedly never be met with Covid-19. " Even if we eradicated the virus in the human population, it would continue to circulate in animals and could undergo unexpected mutations there , ”warns Jean-Claude Manuguerra.
...
https://www.futura-sciences.com/sante/actualites/pandemie-epidemie-covid-19-va-t-elle-arretee-93646/
 
Pathfinder said:
Translation Google

When will the Covid-19 epidemic end?

Celine Deluzarche
Journalist
...
Modified on 23/09/2021
...
Don't expect a drop in virulence

One of the widespread beliefs is that the virus loses its virulence as the pandemic progresses so as not to kill its host, which is also its transmission vector. Unfortunately, this view does not stand up to the analysis of the facts, for example HIV has become more virulent over time. Likewise, the Delta variant appears to cause more severe forms than the Alpha variant. " In the case of SARS-CoV-2, severe symptoms usually appear after two weeks of infection, but more than 95% of transmissions occur before day 11. In other words, from the perspective of this coronavirus, late (particularly inflammatory) manifestations of virulence do not constitute a loss of transmission opportunities.”, says Samuel Alizon, Director of Research at the CNRS and the IRD.

Only one disease in history has been eradicated with a vaccine : smallpox , the last known case of which dates back to 1978 in the United Kingdom. “ This eradication has been possible at the cost of relentless vaccination campaigns for decades. In addition, SARS-CoV-2 has an animal reservoir, so it is almost impossible to eradicate the virus, such as the pathogen of plague, for example, ”says Eric Dortenzio, research director at Inserm. In fact, most of the viruses or bacteria responsible for past pandemics are still present today, be it plague, H1N1 or Ebola. Diseases that are still experiencing sporadic epidemic upsurges.“

Even if the virus were eradicated from the human population, it would continue to circulate in animals and could undergo unexpected mutations.

According to experts, the safest way to end an epidemic is to slow the spread of the disease and counteract its side effects.
Pest control and hygiene standards, for example, have helped control plague and cholera . Triple therapies have drastically reduced AIDS mortality . In the case of measles , vaccination makes it possible to reduce the number of contaminations to almost zero, but this requires practically 100% vaccination coverage and the immunity conferred by the vaccine to be sterilizing. that is, it prevents the transmission of the virus. Two conditions that will undoubtedly never be met with Covid-19. " Even if we eradicated the virus in the human population, it would continue to circulate in animals and could undergo unexpected mutations there , ”warns Jean-Claude Manuguerra.
...
https://www.futura-sciences.com/sante/actualites/pandemie-epidemie-covid-19-va-t-elle-arretee-93646/
Click to expand...

Inserm is with the France National Institute of Health and Medical Research.

His twitter account:

Eric D’Ortenzio
@EricDortenzio
Follows you
Médecin, Epidémiologiste
@agenceANRS

@Inserm

@hopitalbichat

@aphp

@SamusociaParis
« L’essentiel est sans cesse menacé par l’insignifiant » René Char


Doctor, Epidemiologist

@agenceANRS

@Inserm

@hopitalbichat

@aphp

@SamusociaParis
"The essential is ceaselessly threatened by the insignificant" René Char
 
I haven't seen any evidence that delta is more deadly than other variants, just more transmissible. The comparison of a retrovirus to a coronavirus as far as evolution seems a strain.
 
it is expected that SARS2 gets less virulent since - besides the vaccines - more and more people
are infected and develope immunity.

Compare with influenza pandemics.
Compare with other endemic human coronaviruses.

These are obviously more related to the current situation than AIDS etc.
 
just see the mortality estimates for India.
4 Million deaths , 0.28% of its population.
median age=28y , 6%>65 , 3.4%>70
(USA:median==38.3,15.4%>=65,9.7%>=70)
 
Last edited:
Noticed these when shopping for a project respirator.
xhttps://www.homedepot.com/p/3M-Medium-Paint-Project-Respirator-Mask-6211PA1-A/100653900#overlay
Aug 13, 2021
I am using the mask to go walking early in...I am using the mask to go walking early in the morning. I had Covid which left me with COPD and I had bronchitis so bad this summer that I had to stay inside all the time. My pulmonary doctor suggested I try the mask in order to get back into a walking routine. It is working!! I am 75 years young and I also use the mask while mowing my lawn.
by Paula
Click to expand...

Aug 14, 2021
I have been looking for one of these ever since...I have been looking for one of these ever since the COVID-19 hit the air ways, every place I went they didn't have the respirators that I wanted. now that I have it all I need to do is get these filters for it (If you have these filters let me know 2091 P100 or 7093 P100)? I now wear this resperator when I go any where ast it seals around my nose and mouth 100% and when I breath out it does not blow into my eyes as the cloth mask does. thank you for having it in stock
by Ranger12
Click to expand...
 
Hattip Tetano

N Engl J Med . Waning Immune Humoral Response to BNT162b2 Covid-19 Vaccine over 6 Months

https://flutrackers.com/forum/forum...se-to-bnt162b2-covid-19-vaccine-over-6-months

...
Discussion

In this prospective longitudinal study, we found a significant waning of humoral responses within 6 months after receipt of the second dose of BNT162b2 vaccine in a large cohort of 4868 participants. We observed a continuous decrease in anti-S IgG titers at a relative stable rate within 6 months. The decrease in neutralizing antibody titers was brisk initially, in the period of up to 70 to 80 days, but slowed thereafter. Antibody titers were associated with age, sex, and coexisting conditions. Particularly vulnerable populations with lower neutralizing titers were older men and participants with immunosuppression.

Published work about many vaccines, such as those against measles, mumps, and rubella, has shown a small decrease each year of 5 to 10% in the neutralizing antibody levels.13,14 We found that a significant and rapid decrease in humoral response to the BNT162b2 vaccine was observed within months after vaccination.
 
Covid immunity through infection or vaccination: Are they equal?
...
Oct. 7, 2021, 3:00 AM CST / Source: Kaiser Health News
By Arthur Allen, Kaiser Health News
...
The Food and Drug Administration has authorized the use of Covid antibody tests, which can cost about $70, to detect past infections. Some tests can distinguish whether the antibodies came from infections or vaccines. But neither the FDA nor the Centers for Disease Control and Prevention recommend using the tests to assess whether you’re, in fact, immune to Covid. For that, the tests are essentially useless, because there’s no agreement on the amount or the types of antibodies that would signal protection from the disease.

“We don’t yet have full understanding of what the presence of antibodies tells us about immunity,” said Kelly Wroblewski, the director of infectious diseases at the Association of Public Health Laboratories.
...
CDC spokesperson Kristen Nordlund said in an email that “current evidence” shows wide variation in antibody responses after Covid infection. “We hope to have some additional information on the protectiveness of vaccine immunity compared to natural immunity in the coming weeks,” she said.
...
https://www.nbcnews.com/health/heal...ection-or-vaccination-are-they-equal-n1280962
 
use a scissors and a normal mask or hepa-vaccum-cleaner-bag
I was looking for a respirator that uses these small rectangular hepa-filters
 
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