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Discussion thread VI - COVID-19 (new coronavirus)

you can get them, but it costs more than usual. $10 ?
I agree, that they should really have figured it out by now, how it spreads,
what helps to prevent it.
 
What I can see on a major delivery site is that the only NIOSH approved N95 masks that have the valve are advertised. And they are asking about $7 each for these. Many places do not allow the masks with valves because these masks allow the wearer's breath to exhale out. i.e. The wearer is protected but no one else. I have no idea if the advertised masks are in stock as I did not try to buy any.
 
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kiwibird said:
https://twitter.com/aliostad/status/1285701000607793153

Twitter link listing probable reinfections, including severe and fatal reinfections, in Iran.
Click to expand...

https://www.reuters.com/article/us-h...-idUSKCN26C2X1

Another case of reinfection after recovery from COVID-19 has been reported, this time in a healthy young military healthcare provider at a U.S. Department of Defense hospital in Virginia. He was first infected by a patient in March. He recovered within 10 days and "returned ... to excellent health," his doctors reported on Saturday in Clinical Infectious Diseases. Fifty-one days later, he was reinfected by a household member. Genetic studies showed the first and second infections to be from slightly different strains of the virus. The reinfection made him sicker, perhaps because the second strain was more potent, or the household contact infected him with a higher load of virus, doctors said. It was also possible antibodies from the first infection may have triggered his immune system to respond more strongly to the virus the second time his body encountered it.
Click to expand...

The number of implications for either of these proposed reasons for the second infection being worse than the first are horrendous!
 
I would be shocked if the reason the reinfection was not as mild was due to either higher initial viral load or a different phenotype. The viral load generated by in host replication will quickly swamp what ever viral load there was at infection and there is no record of any other circulating phenotype.
Obviously the first infection did not provide sterilising immunity but may well have induced an immune response that kicked in hard and fast second time around. Without further details of what happened next in this patient's second infection it is difficult to attribute a mechanism. Did he quickly clear the virus or did he go on to get seriously ill? If the former then the fast immune response releasing lots of inflammatory cytokines fits but if the later I would be looking for residual damage from the first infection leaving him more vulnerable to infections generally.
 
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People could have developed undiagnosed malignancies or other infections in between the first and second infection that could interfere with immunity. Also, there could be new environmental exposures prior to the second infection. Heavy metals can impact immunity:
https://www.sciencedirect.com/science/article/pii/0041008X91901293

Also, the personal health habits of the person may have changed between the first and second infection. There are a lot of possibilities other than the Covid virus evolving virulence or a dengue type immune problem.
 
I participated in a thread - which I can not now find - regarding UVC bulbs as a means to kill virus but what I had read up to that point led me to think the higher energies involved would lead to all the problems caused by UVA and B exposure would be worse with UVC. In part this is correct but it turns out that once you get up to 220nm (far UVC) things change and these wave lengths can not penetrate through skin or even the mucosal film over the eyes. It can however effectively inactivate viruses and bacteria. There had been little interest in manufacturing these bulbs but now they are being produced and can be used even when in rooms full of people. They have already been fitted in some lifts and others, like the NY transit authority, are looking at getting them into tube trains.
This is a potential game changer for a wide range of microbial pathogens in many high contact settings, nursing homes, schools, planes, trains and work places.
The links will provide information on the safety testing, efficacy etc.
https://www.nature.com/articles/s41598-018-21058-w
https://www.microbe.tv/twiv/twiv-666/
 
Ok. Over the top.

US - Colorado: Boulder health department bans "Gatherings of any size within the City of Boulder of anyone 18-22 years old" - September 24, 2020
  • CU Students will also be reported to CU for potential discipline under the Student Code of Conduct process. CU Discipline can include exclusion from campus, suspension, and, in the worst cases, expulsion.
----------------------------

I personally know people who are keeping their college age children out of Boulder in response to this measure. What is a gathering of any size? 2 people?
 
snip

“I think there’s good enough data to say that aerosol transmission does occur,” Dr. Fauci, the country’s leading infectious disease expert, said in a live Facebook discussion with Gov. Philip D. Murphy of New Jersey. “Aerosol means the droplets don’t drop immediately. They hang around for a period of time.”

Dr. Fauci’s assessment comes at a time when state and local authorities are trying to find reliable guidance for what mitigation efforts are needed indoors and how indoor spaces should be ventilated.


https://www.nytimes.com/2020/09/24/w...#link-6d900248
 
Sharon, yes and thanks. I was searching on JJackson & UVC but it ignored the UVC and gave me so many posts I gave up looking after a while. I was going to post there but this thread should garner more eyeballs and I think it could be major player in getting the economy going. The primary site of transmission in well documented 'super spreader' events in Japan and Hong Kong show indoor gatherings in pubs, clubs, choirs, places of worship etc. are the problem. Lighting that inactivates small droplets/aerosols would probably be as effective as masks in this setting and the two together would make a major difference in work places and schools. The new normal unfortunately. The bit I do not get is if this technology exists and is deployable why are they not already in all ICUs, infectious disease wards, operating theaters? The same goes for low cost rapid antigen tests for SARS, who cares if they are a day later in picking up the infection if they tell you immediately and are cheap enough to test everyone twice a week. You have to pick up far more people far more quickly than with $100 a pop PCR test (if you can get one) that comes back days later.
 
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Google Services Go Down in Some Parts of U.S.

People experienced outages of services like Gmail, YouTube and Google Meet.

more..

https://www.nytimes.com/2020/09/24/technology/google-service-outage.html

-------------------------------------------------------

Facebook and Instagram had outages last Thursday:

Instagram and Facebook were down for some users in North America and Europe

Avery Hartmans
Sep 17, 2020, 2:39 PM

https://www.businessinsider.com/ins...gram and Facebook appeared to,of 2:30 p.m. ET.
 
JJackson commented
September 23, 2020, 07:36 AM

I would be shocked if the reason the reinfection was not as mild was due to either higher initial viral load or a different phenotype. The viral load generated by in host replication will quickly swamp what ever viral load there was at infection and there is no record of any other circulating phenotype.
Click to expand...

I think initial viral load is very important. (That's why COVID parties are a bad idea even for young people and why even sub-N95 masks can reduce severe illnesses in certain high-risk circumstances.) The research about ultimate viral load and outcomes seems to have more conflicting research right now. I think that is what you are thinking about.

https://www.medpagetoday.com/infecti.../covid19/88692
Does Virus Dose or Load Predict How Sick You Get With COVID-19?

— Initial exposure, strength of virus infection both seen as contributors to illness severity

by Amanda D'Ambrosio, Staff Writer, MedPage Today September 18, 2020
Click to expand...
 
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