Cytokine Storm & Vitamin D relationship?

tropical · Jul 8, 2009

Re: Cytokine Storm & Vitamin D relationship?

#285:
"perked up an eyebrow when I talk about Vitamin D Supplementation, and it's very powerful benefits, and protective qualities."

Usualy, the individual additional taking of daily vitamin D suplements are subjected to an previous specialistic health professional dosage, and previous lab tests which are not usualy prescribed to be tested by the GP, if they thinks unneccessary in absence of vit.D pertinent illnesses.

So, it is understandable that a presence of wide official health minimization of informations, additionaly with a lack of prescribed/suggested vitamin D suplements, lead to a prudent aproach when suggested to take even more greater daily dosages, especialy if the person don't know to have a deficite of vit. D., or think it haven't.
___
So if the person have normal levels it is not supposed to take more of it, especialy much more doses, or it is stil to be taken as an augmented flu prophilactic for months(?)

ming · Jul 17, 2009

Re: Cytokine Storm & Vitamin D relationship?

Can I ask those who know about this - is vit D obtained by sunlight on skin, exactly the same as vit D obtained by supplement pills ?

peter m · Jul 17, 2009

Re: Cytokine Storm & Vitamin D relationship?

I want to thank the Doctor and Shannon for their recommendations and advise on Vit D-3 and it's role in combatting/mimimizing the SW flu Pandemic. I have become a true believer and may be the most UV- bombarded &
toasted person in Scal(i spend a lot of time outdoors- Am a surf and cycling nut if u really need to know, plus i have a garden).

Come Oct I wiil take 5000 Iu's per day in pill form, as the natural UV''s from the sun will decrease significantly here in Scal. This is just one part of an overall comprehensive plan for boosting my health and immune systems as the second deadly pandemic wave sweeps across america, hitting SCal in Oct, perhaps earlier.

AlaskaDenise · Jul 17, 2009

Re: Cytokine Storm & Vitamin D relationship?

ming said:
Can I ask those who know about this - is vit D obtained by sunlight on skin, exactly the same as vit D obtained by supplement pills ?

The short answer is yes. There are good articles about your question intersperced throughout this thread. One very informative source is a video at: http://www.flutrackers.com/forum/showpost.php?p=255866&postcount=99 The video is a bit long, but worth your time to watch it.

.

tropical · Jul 18, 2009

Re: Cytokine Storm & Vitamin D relationship?

I must frankly said that after talking with 5 diferent area sub-specialists hospital doctors, no one thinks it is a good idea taking pils/drops of vitamin D supplements even in low precautionary dosages.

In areas with enaugh sun, their suggestion were to take only morning/evening sun exposures, and food rich in vitamin D.

tropical said:
#285:
"perked up an eyebrow when I talk about Vitamin D Supplementation, and it's very powerful benefits, and protective qualities."

Usualy, the individual additional taking of daily vitamin D suplements are subjected to an previous specialistic health professional dosage, and previous lab tests which are not usualy prescribed to be tested by the GP, if they thinks unneccessary in absence of vit.D pertinent illnesses.

So, it is understandable that a presence of wide official health minimization of informations, additionaly with a lack of prescribed/suggested vitamin D suplements, lead to a prudent aproach when suggested to take even more greater daily dosages, especialy if the person don't know to have a deficite of vit. D., or think it haven't.
___
So if the person have normal levels it is not supposed to take more of it, especialy much more doses, or it is stil to be taken as an augmented flu prophilactic for months(?)

ming · Jul 18, 2009

Re: Cytokine Storm & Vitamin D relationship?

Thanks Denise !

Edited to add- We are at lat 56, should we take supplementary vit D all year round ?

kiwibird · Jul 18, 2009

Re: Cytokine Storm & Vitamin D relationship?

SuperNova1987A

:tiphat:
from this thread
<script type="text/javascript"> vbmenu_register("postmenu_266836", true); </script>
http://www.flutrackers.com/forum/showthread.php?p=266836#post266836
Margarine in Japan and the UK is fortified with Vitamin D

As for margarine and vitamin D, here I submit my homework.
Do you see any correlation?

_______________________
SN1987A

The above figures relate to Supernovas study of Japan

tropical · Jul 18, 2009

Re: Cytokine Storm & Vitamin D relationship?

#291:
"After performing many hours of research on vitamin D and actually communicating with world leaders in vitamin D research (decades of experience with clinical trials) I have come to the conclusion;

Vitamin D supplementation is a good idea.
...
Too much of anything is bad, but the human body can produce 10,000 iu of vitamin D (fair skinned) in ten minutes sun exposure and it has worked successfully for 5 million years of evolution. Winter supplementation of vitamin D should be mandatory for the thinking person living above 35 degrees latitude, daily dosage based on weight, age, and other risk factors. There are many that need year round supplementation, who cannot take full advantage of summer sunshine due to extreme latitude, age, skin pigmentation, or other environmenal factors. " 

The point of mine post #290 was that nobody officialy suggests or are not informed, nor have directives to diramate through GP, or by the media, any directives of ingestion to the population of vitamin D, or other cheap generic compound, as a pandemic flu preventive.

So, it is not matter widely if it works, if the masses don't know or are not directed to by their health estabs.

With all my respect, I suggest to the above cited: "world leaders in vitamin D research (decades of experience with clinical trials)" ,
to exit the scientific studies diatribes and make an joint statement to the worldwide scientific and health community, for an worldwide fast official guidance for vitamin D (or other) pandemic suplementation of the population - especialy if those professionals are not multinational corporations researchers only, and if they are - to act through the official estab systems openly to explain this need.

Any blogging depiction of various studies, or shadowed needings communications, will not enhance the usage in the wide world population - if this is the goal of this thread.

If the goal is to porge the knowledge only here,
than it will be an individual decision of the surfers, because this is not an official public health guideline, ad example as was the one to insert iode in salt.

Does the insertion of vitamins in the margarin are a result of public health guidelines, or food producers, as many other aditives in many food, or not?
Any way, many don't eat margarin, but butter or nothing, because of supposed more genuinity (even if all the industrial processed food are now somehow tampered).

Shannon Bennett · Jul 18, 2009

Re: Cytokine Storm & Vitamin D relationship?

Ming,

I would get a GP to measure my D levels right now. I suspect your levels are low simply because of your latitude. So, the answer is probably yes, you will have to take this year round.

ming · Jul 18, 2009

Re: Cytokine Storm & Vitamin D relationship?

ok thanks - and I am ordering some online today - although I suppose they take time to work.

tropical · Jul 18, 2009

Re: Cytokine Storm & Vitamin D relationship?

#298:...

We now came to the core of this cheap generic compound question.

It is the health "caste" that mainly don't want to air any novel usage out of the traditional ones, or the corporation reclamized as "working".

That's why all the countries have their's inner evaluation system which must give recommendations, additionaly to the worldwide ones.

And they also are the ones who must make this evaluation about vitamins/... as an anti-pandemic measure.
And they didn't.

Until that will not be the case, there will be no efforts to treating by compounds the bilions (if this realy works) until the illness would not be overwhelming, and than it will be maybe late.

So, this cheap compounds effort seems will remain an individual effort.

AlaskaDenise · Jul 18, 2009

Re: Cytokine Storm & Vitamin D relationship?

ming said:
ok thanks - and I am ordering some online today - although I suppose they take time to work.

Shannon brings up an important point - get your Vitamin D levels checked. I would also suggest getting the levels checked again after a few months of sun and supplements. Depending on a number of variables, your levels may not be what you expect.

Meanwhile, spend 15-20 minutes in the full sun each day while the sun is still producing sufficient UV rays.

.

AlaskaDenise · Jul 30, 2009

Re: Cytokine Storm & Vitamin D relationship?

I just found a new form of vitamin D-3. It's Gummie D-3. Yep, they're good tasting soft small chewy flavored 1000 IU small rounds. They're "Spring Valley" brand at Walmart and it's $5.34 for 150 gummies. They taste good. It's D-3 as cholecalciferol.

.

Merricat · Aug 6, 2009

Re: Cytokine Storm & Vitamin D relationship?

I have been reading these posts regarding vit d and I recall reading a scientific article that stated that L bacteria in the intestines can prevent vit d at the vit d receptor site and that to allow the vit d receptor to process it you must decrease the L bacteria in the intestines. So is it possible that this is why there is a vit d defieciency in most people? I will try to find the link, but it was months ago that I read the article. It appears that maybe some rx with acidophilus for a while would rid the L bacteria and allow absorption of the vit d????
anyone have a comment or knowledge of this?
thanks,

Merricat.

sharon sanders · Aug 17, 2009

Re: Cytokine Storm & Vitamin D relationship?

bump this.

Emily · Aug 31, 2009

Re: Cytokine Storm & Vitamin D relationship?

Stocked up on some higher dosage vitamin D in an oil form today and noticed that it was derived from wool oil. That was news to me but I see that mentioned in other threads here.

cartski · Aug 31, 2009

Re: Cytokine Storm & Vitamin D relationship?

Emily said:
Stocked up on some higher dosage vitamin D in an oil form today and noticed that it was derived from wool oil. That was news to me but I see that mentioned in other threads here.

So, whenever I use shaving cream, made from lanolin, I get a shot of vit D?

)

J.

Shannon Bennett · Aug 31, 2009

Re: Cytokine Storm & Vitamin D relationship?

http://www.jimmunol.org/cgi/content/abstract/179/4/2060

<HR align=left color=#000000 noShade SIZE=1> [SIZE=-1]The Journal of Immunology, 2007, 179, 2060 -2063
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Cutting Edge: Vitamin D-Mediated Human Antimicrobial Activity against Mycobacterium tuberculosis Is Dependent on the Induction of Cathelicidin1

Philip T. Liu*, Steffen Stenger
$dagger.gif$
, Dominic H. Tang* and Robert L. Modlin2,*

[SIZE=-1]* Division of Dermatology, Department of Medicine, and Department of Microbiology, Immunology and Molecular Genetics, David Geffen School of Medicine, University of California, Los Angeles, CA 90095; and

$dagger.gif$

Institute for Medical Microbiology and Hygiene, University of Ulm, Ulm, Germany [/SIZE]
Host defense against intracellular pathogens depends upon innate and adaptive antimicrobial effector pathways. TLR2/1-activation of monocytes leads to the vitamin D-dependent production of cathelicidin and, at the same time, an antimicrobial activity against intracellular Mycobacterium tuberculosis. To determine whether induction of cathelicidin was required for the vitamin D-triggered antimicrobial activity, the human monocytic cell line THP-1 was infected with M. tuberculosis H37Ra and then activated with the active vitamin D hormone 1,25-dihydroxyvitamin D3 (1,25D3). 1,25D3 stimulation resulted in antimicrobial activity against intracellular M. tuberculosis and expression of cathelicidin mRNA and protein. Using small interfering RNA (siRNA) specific for cathelicidin, 1,25D3-induced cathelicidin mRNA and protein expressions were efficiently knocked down, whereas a nonspecific siRNA control had little effect. Finally, 1,25D3-induced antimicrobial activity was completely inhibited in the presence of siRNA against cathelicidin, instead leading to enhanced intracellular growth of mycobacteria. These data demonstrate that cathelicidin is required for the 1,25D3-triggered antimicrobial activity against intracellular M. tuberculosis. 
The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked advertisement in accordance with 18 U.S.C. Section 1734 solely to indicate this fact. 
1 This work was supported in part by National Institutes of Health Grants R01 AI22553, R01 AI47868, and R01 AR40312. P.T.L. is supported by Microbial Pathogenesis Training Grant 2-T32-AI-07323. S.S. is funded by Deutsche Forschungsgemeinschaft SFB 643. 
2 Address correspondence and reprint requests to Dr. Robert L. Modlin, Division of Dermatology, University of California Los Angeles, 52-121 Center for the Health Sciences, 10833 Le Conte Avenue, Los Angeles, CA 90095. E-mail address: rmodlin@mednet.ucla.edu<SCRIPT type=text/javascript></SCRIPT> 3 Abbreviations used in this paper: 1,25D3, 1,25-dihydroxyvitamin D3; MOI, multiplicity of infection; qPCR, quantitative PCR; siRNA, small interfering RNA; siCath, siRNA specific for the cathelicidin gene; ciCTRL, nonspecific siRNA control oligo.

Shannon Bennett · Aug 31, 2009

Re: Cytokine Storm & Vitamin D relationship?

Here we go, Merricat. http://www.sciencemag.org/cgi/content/abstract/311/5768/1770

<TABLE class=LayoutTable cellSpacing=0 cellPadding=0 border=0><TBODY><TR><TD>Originally published in Science Express on 23 February 2006
Science 24 March 2006:
Vol. 311. no. 5768, pp. 1770 - 1773
DOI: 10.1126/science.1123933
</TD><TD>Prev | Table of Contents | Next
</TD></TR></TBODY></TABLE>
Reports

Toll-Like Receptor Triggering of a Vitamin D-Mediated Human Antimicrobial Response

Philip T. Liu,1,2* Steffen Stenger,4* Huiying Li,3 Linda Wenzel,4 Belinda H. Tan,1,2 Stephan R. Krutzik,2 Maria Teresa Ochoa,2 J?rgen Schauber,5 Kent Wu,1 Christoph Meinken,4 Diane L. Kamen,6 Manfred Wagner,7 Robert Bals,8 Andreas Steinmeyer,9 Ulrich Z?gel,10 Richard L. Gallo,5 David Eisenberg,3 Martin Hewison,11 Bruce W. Hollis,12 John S. Adams,11 Barry R. Bloom,13 Robert L. Modlin1,2
$dagger.gif$


In innate immune responses, activation of Toll-like receptors (TLRs) triggers direct antimicrobial activity against intracellular bacteria, which in murine, but not human, monocytes and macrophages is mediated principally by nitric oxide. We report here that TLR activation of human macrophages up-regulated expression of the vitamin D receptor and the vitamin D-1?hydroxylase genes, leading to induction of the antimicrobial peptide cathelicidin and killing of intracellular Mycobacterium tuberculosis. We also observed that sera from African-American individuals, known to have increased susceptibility to tuberculosis, had low 25-hydroxyvitamin D and were inefficient in supporting cathelicidin messenger RNA induction. These data support a link between TLRs and vitamin D?mediated innate immunity and suggest that differences in ability of human populations to produce vitamin D may contribute to susceptibility to microbial infection. 

[SIZE=-1]1 Department of Microbiology, Immunology, and Molecular Genetics; University of California at Los Angeles, Los Angeles, CA 90095, USA.
2 Division of Dermatology, Department of Medicine, David Geffen School of Medicine; University of California at Los Angeles, Los Angeles, CA 90095, USA.
3 Department of Chemistry and Biological Chemistry, Howard Hughes Medical Institute; and Department of Energy Institute of Genomics and Proteomics, University of California at Los Angeles, Los Angeles, CA 90095, USA.
4 Institut f?r Klinische Mikrobiologie, Immunologie, und Hygiene, Universit?t Erlangen, D-91054 Erlangen, Germany.
5 Division of Dermatology, University of California at San Diego, and Veterans Affairs San Diego Healthcare Center, San Diego, CA 92161, USA.
6 Department of Medicine, Medical University of South Carolina (MUSC), Charleston, SC 29425, USA.
7 Klinikum N?rnberg, Medizinische Klinik 3, D-90340 N?rnberg, Germany.
8 Pneumologie, Universit?t Marburg, D-35043 Marburg, Germany.
9 Medicinal Chemistry, Schering AG, D-13342 Berlin, Germany.
10 Corporate Research Business Area (CRBA) Dermatology, Schering AG, D-13342 Berlin, Germany.
11 Department of Medicine, Division of Endocrinology, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
12 Departments of Pediatrics, Biochemistry, and Molecular Biology, MUSC, Charleston, SC 29425, USA.
13 Harvard School of Public Health, Boston, MA 02115, USA. [/SIZE]
* These authors contributed equally to this work.

$dagger.gif$

To whom correspondence should be addressed. E-mail: rmodlin{at}mednet.ucla.edu<SCRIPT type=text/javascript></SCRIPT>

Shannon Bennett · Aug 31, 2009

Re: Cytokine Storm & Vitamin D relationship?

My search for Merricats information has brought me some unexpected results. It appears that MRSA infections and a low vit D rate among hospital patients have a strong correlation. I cannot open any of these links but here are a few studies linking the two phenomena. In the second study and in several other studies there appears to be a link between low vit. d levels and tuberculosis.

http://www.journals.uchicago.edu/doi/abs/10.1086/425321

http://www.journals.uchicago.edu/doi/abs/10.1086/313658

http://www.journals.uchicago.edu/doi/abs/10.1086/374243

Cytokine Storm & Vitamin D relationship?

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