Bihar: Unidentified disease kills 56 children - undetermined encephalitis - samples negative for JE, Nipah and Chandipura

[Treyfish]

Re: Bihar: Mysterious disease kills 44 children - undetermined encephalitis - samples negative for JE, Nipah and Chandipura

Re: Bihar: Mysterious disease kills 44 children - undetermined encephalitis - samples negative for JE, Nipah and Chandipura

Encephalitis: shrouded in mystery, and death


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Jun 26, 09:21 pm​

Jun 26, 09:21 pm

Mission Encephalitis

-​

- Death toll
48, one new patient admitted
- Civil hospital new baby in the open ward with a capacity of 15 beds

-​

- DM medicine charge and
Meeting with Seedeepio

-​

- Affected 63 villages in the fogging
And spraying CONDUCT
- Home - Home revolving Health Survey
Team, the report will be sent to Pune
- Will be taken in cleaning of IRCON
Help, the task of drainage
Muzaffarpur, Casn a Pkware continues even after the havoc of encephalitis in the district. Suspected disease is not only shrouded in mystery, but the process of death is not to stop.
Manisha Kumari on Sunday suffering from disease and she died. The death toll is now 48.The symptoms of Motipur Rohit Kumar on a two-admitted to the hospital. Children 6 to 26 and Skemsiac admitted to the hospital. :tiphat:http://translate.googleusercontent....0.html&usg=ALkJrhg6iqR9Vzhblgq2oFoFM41oysy7IQ

 

[Treyfish]

Re: Bihar: Mysterious disease kills 44 children - undetermined encephalitis - samples negative for JE, Nipah and Chandipura

Re: Bihar: Mysterious disease kills 44 children - undetermined encephalitis - samples negative for JE, Nipah and Chandipura

Goat, dog, cock from the sample, stream out of the larvae

Meenapur (Muzaffarpur), personal representative: Isefelaitis looking for the virus, Patna and Pune Meenapur the team is once again at Target. Member of the team reached the affected villages and goat, dog, cock, serum and saliva samples collected from bulls. The patient was in the house, the house was set up in a garden with mosquito sampling. Trapped mosquitoes and other birds will be caught up in the morning.Different group of experts - belonged to different campaigns.

He is heading the team is full of people. Collection of mosquito larvae net has become a topic of surprise.Meanwhile, a year Mahdeiya afflicted with Sudhanshu fever and cough. The families are treated at private hospitals. Mahdeniyan team field on Sunday, Purania, Ckjmal and Hrpur Bksl, Madhubani village took a sample of animals and mosquitoes. :tiphat:http://translate.googleusercontent....0.html&usg=ALkJrhgbLuCmk3xIu0sR2Fo2VMZh5aya3g

 

[Treyfish]

Re: Bihar: Mysterious disease kills 44 children - undetermined encephalitis - samples negative for JE, Nipah and Chandipura

Re: Bihar: Mysterious disease kills 44 children - undetermined encephalitis - samples negative for JE, Nipah and Chandipura

The research will target these
Three stages of the disease, research is currently underway. Pathology, mosquitoes, pigs, buffalo, chicken, goat and bull. :tiphat:http://translate.googleusercontent....1.html&usg=ALkJrhg64zIU7eCg0u-TfqLB-lMf4gD1Xw

 

[Treyfish]

Re: Bihar: Mysterious disease kills 44 children - undetermined encephalitis - samples negative for JE, Nipah and Chandipura

Re: Bihar: Mysterious disease kills 44 children - undetermined encephalitis - samples negative for JE, Nipah and Chandipura

[FONT=6a4f87cdfe317b270865abe0#841100]..Disease spreads to the Bhagalpur and Munger[/FONT]

[FONT=6a4f87cdfe317b270865abe0#841100]Bhagalpur and Munger district in the state of the patient having symptoms of the disease to get the news.[/FONT] [FONT=6a4f87cdfe317b270865abe0#841100]This disease is high fever and the child becomes unconscious:tiphat:http://translate.googleusercontent....3-UPD=&usg=ALkJrhhQKbR_1fvNz6VV3IJ_brswyYl0zA[/FONT]

 

[Ronan Kelly]

Re: Bihar: Mysterious disease kills 44 children - undetermined encephalitis - samples negative for JE, Nipah and Chandipura

Re: Bihar: Mysterious disease kills 44 children - undetermined encephalitis - samples negative for JE, Nipah and Chandipura

Toll 47, Bihar may declare mystery disease epidemic

Santosh Singh,Santosh Singh
Posted: Jun 27, 2011 at 0311 hrs IST

Patna With the death toll in the mysterious disease rising to 47 on Sunday, the Bihar government is likely to declare it an epidemic.
Under the epidemic Act, the Health Ministry will be empowered to take samples of brain tissues of the mystery disease victims.

Six deaths have been reported during the last 48 hours, including five at K D Kejriwal Maternity Hospital. The hospital, which has admitted 82 patients since June 11, reported 24 deaths till Sunday evening including one on Sunday. Seventeen children are being treated at the hospital.

Muzaffarpur?s government hospital, Sri Krishna Medical College and Hospital, reported one death during the last 48 hours. It has been treating eight patients. Patna Medical College and Hospital has seven patients.

At the National Institute of Virology, Pune, and Rajendra Memorial Research Institute, Patna, 24 blood and cerebral spinal fluid samples have tested negative for Japanese encephalitis (JE). These institutes now want brain tissue samples to ascertain the disease that experts describe as a kind of viral encephalitis. Culex mosquitoes are suspected to carry virus from animals to humans.

Muzaffarpur district magistrate recommended the state government late on Saturday night to declare Gandak catchment and suburban areas of Bochaha, Minapur, Mushahari, Kanti, Ahiyapur, Sahebganj and Paru as epidemic zone. The district administration has set up a five-member doctors? committee to advise line of treatment and help prepare a contingency plan. Dr Arun Shah, one of the members of the committee, said Muzaffarpur cases needed the same treatment as Saharanpur encephalitis that led to a large number of deaths every year till 2000. ?A study by the Indian Council of Medical Research concluded that a toxin from kasaundhi trees, being transmitted to humans through insects, caused the disease. The trees were cut and the disease subsided. Litchi trees and mosquitoes present in the region should be studied for this disease,? suggested Shah.

Health Minister Ashwini Kumar Choubey said, ?We have received Muzaffarpur administration?s advice to declare the disease as epidemic. We have started the process. We urgently need brain tissues to decode the mystery. The government will take a final call on Monday after assessing the situation. Experts have given us enough hints of it being some kind of a viral disease affecting brain and causing sudden death. Declaration of epidemic would help us get the exact diagnosis,? he said.

Chief Minister Nitish Kumar said that irrespective of blood sample tests ruling out Japanese encephalitis, JE vaccine should be given to all children below 15 years in affected areas.
http://www.expressindia.com/latest-news/Toll-47--Bihar-may-declare-mystery-disease-epidemic/809168/

 

[alert]

Re: Bihar: Mysterious disease kills 44 children - undetermined encephalitis - samples negative for JE, Nipah and Chandipura

Re: Bihar: Mysterious disease kills 44 children - undetermined encephalitis - samples negative for JE, Nipah and Chandipura

Toll 47, Bihar may declare mystery disease epidemic
Muzaffarpur district magistrate recommended the state government late on Saturday night to declare Gandak catchment and suburban areas of Bochaha, Minapur, Mushahari, Kanti, Ahiyapur, Sahebganj and Paru as epidemic zone. The district administration has set up a five-member doctors’ committee to advise line of treatment and help prepare a contingency plan. Dr Arun Shah, one of the members of the committee, said Muzaffarpur cases needed the same treatment as Saharanpur encephalitis that led to a large number of deaths every year till 2000. “A study by the Indian Council of Medical Research concluded that a toxin from kasaundhi trees, being transmitted to humans through insects, caused the disease. The trees were cut and the disease subsided. Litchi trees and mosquitoes present in the region should be studied for this disease,” suggested Shah.

http://www.expressindia.com/latest-news/Toll-47--Bihar-may-declare-mystery-disease-epidemic/809168/

This may be a very important clue. "Saharanpur encephalitis" is the name of the disease linked in the ProMED post (http://www.promedmail.org/pls/apex/...CHECK_DISPLAY,F2400_P1202_PUB_MAIL_ID:X,86430) linked in post #27 of this thread, and is in fact not infectious, but rather the result of a toxin.

The ProMED post actually claims that Saharanpur encephalitis is not spread by mosquitoes, but by the children actually ingesting the toxic plant in question:

It could even be a non-infectious problem (such as the
'hepatomyoencephalopathy' we have described in western UP -- it was
called Saharanpur encephalitis for over 2 decades and investigated by
NIV repeatedly. Our systematic studies showed it to be _Cassia
occidentalis_ poisoning of children who ate lots of the beans.

---------

[A Google search for "kasaundhi", the name of the plant in the new article does not reveal anyother references to this plant that might indicate whether it is the same plant. - alert]

 

[Ronan Kelly]

Re: Bihar: Mysterious disease kills 48 children - undetermined encephalitis - samples negative for JE, Nipah and Chandipura

Re: Bihar: Mysterious disease kills 48 children - undetermined encephalitis - samples negative for JE, Nipah and Chandipura

Here's that paper; http://www.sshchd.org/research/1196... outbreaks of a hepato-myo-encephalopathy.pdf

Recurrent annual outbreaks of a hepato-myo-encephalopathy
syndrome in children in western Uttar Pradesh, India

V.M. Vashishtha, N.C. Nayak*, T. Jacob John** & Amod Kumar+
Mangla Hospital, Bijnor, *Sir Ganga Ram Hospital, New Delhi, **Christian Medical College, Vellore
& +Department of Community Health, St. Stephens Hospital, New Delhi, India
Received June 22, 2006

Background & objectives: Outbreaks of an acute encephalopathy syndrome affecting children, with
high case-fatality, have been reported in western Uttar Pradesh, India for the last many years.We
investigated these cases in Bijnor district and present our findings.

Methods: Fifty five children aged 2-10 yr hospitalized from 2003 to 2005 in Bijnor, Uttar Pradesh,
with features of acute encephalopathy were selected by defined clinical criteria. Various laboratory
investigations were performed.

Results: The disease had peak incidence in early winter months. Previously healthy, 2-4 yr old
rural children (mean age-3.78 yr) of very low socio-economic background were most vulnerable.
Almost all had vomiting preceding unconsciousness and a majority had mild fever and abnormal
behaviour/agitation. Abnormal posture of trunk and limbs were distinctive features. Fluctuation
of blood pressure was seen in three-quarter cases. Serum aminotransferases, creatine
phosphokinase and lactic dehydrogenase levels were found markedly raised virtually in all cases
in whom the tests were performed. Serum glucose was found low (<50 mg/dl) in 47.3 per cent
cases at presentation. Cerebrospinal fluid (CSF) was under normal or low pressure and without
pleocytosis in all cases. No microorganism could be isolated from serum, CSF, urine and visceral
specimens. Neuroimaging performed in two cases was also normal. Liver biopsy performed in 21
cases showed acute hepatotoxic injury in all with marked hydropic change and perivenular necrosis.
Tibial muscle biopsy done in 8 cases showed focal necrosis while brain biopsy taken in 2 cases
had mild spongiosis with focal gliosis. Forty two children succumbed to their illness (case fatality
76.4%), most within 72 h of presentation. Survivors did not show any neurological deficit.

Interpretation & conclusion: Our findings showed that the outbreaks were due to a multi-system
disease with toxic injury to liver, muscles and brain (hepato-myo-encephalopathy) and not due to
viral encephalitis as believed so far. The cause remains unknown but several features suggest
the possibility of phytotoxin-induced pathology.

...

full paper available at link.

 

[Ronan Kelly]

Re: Bihar: Mysterious disease kills 48 children - undetermined encephalitis - samples negative for JE, Nipah and Chandipura

Re: Bihar: Mysterious disease kills 48 children - undetermined encephalitis - samples negative for JE, Nipah and Chandipura

and the follow up;

Cassia occidentalis poisoning as the probable cause of
hepatomyoencephalopathy in children in western Uttar Pradesh

V. M. Vashishtha, Amod Kumar*, T. Jacob John+ & N.C. Nayak#
Mangla Hospital, Bijnor (UP) ,*Department of Community Health, St Stephens Hospital, New Delhi
+Christian Medical College,Vellore & #Sir Ganga Ram Hospital, New Delhi, India
Received November 7, 2006

Background & objectives: Recurrent annual outbreaks of acute encephalopathy illness affecting young
children have been reported for several years in many districts of western Uttar Pradesh (UP). Our earlier
investigations over three consecutive years (2002-2005) proved that these outbreaks were due to a fatal
multi-system disease (hepatomyoencephalopathy syndrome) probably caused by some phytotoxin and not
due to viral encephalitis as believed so far. We conducted a case-control study to investigate the risk, if any,
from various environmental factors and also to identify the putative toxic plant responsible for development
of this syndrome.

Methods: Eighteen cases with acute hepatomyoencephalopathy syndrome admitted in 2005 in a secondary
care paediatric hospital of Bijnor district of western UP were included in the study. Three age-matched
controls were selected for each case. A semi-structured questionnaire was developed and applied to all 18
cases and 54 controls. All interviews were conducted within one week of discharge or death of each case.
Quantitative data were analyzed using the relevant established statistical tests.

Results: Parents of 8 (44.4%) cases gave a definite history of their children eating beans of Cassia occidentalis
weed before falling ill, compared with 3 (5.6% controls), the odds ratio being 12.9 (95% CI 2.6-88.8,
P<0.001). History of pica was the other associated factor with the disease, odds ratio 5.20 (95% CI 1.4-
19.5, P<0.01). No other factor was found significantly associated with the disease.

Interpretation & conclusions: Consumption of C. occidentalis beans probably caused these outbreaks,
described earlier as hepatomyoencephalopathy syndrome. Public education has the potential to prevent
future outbreaks.

...

http://www.sshchd.org/research/1196332732_Cassia occidentalis poisoning as the probable cause of.pdf

 

[alert]

Re: Bihar: Mysterious disease kills 48 children - undetermined encephalitis - samples negative for JE, Nipah and Chandipura

Re: Bihar: Mysterious disease kills 48 children - undetermined encephalitis - samples negative for JE, Nipah and Chandipura

And here's likely the same illness (with a different plant suspect, but possibly a similar toxin) from across the border in Bangladesh:

http://www.plosone.org/article/info:doi/10.1371/journal.pone.0009756

Fatal Outbreak from Consuming Xanthium strumarium Seedlings during Time of Food Scarcity in Northeastern Bangladesh

Abstract

Background
An outbreak characterized by vomiting and rapid progression to unconsciousness and death was reported in Sylhet Distrct in northeastern Bangladesh following destructive monsoon floods in November 2007.

Methods and Findings
We identified cases presenting to local hospitals and described their clinical signs and symptoms. We interviewed patients and their families to collect illness histories and generate hypotheses about exposures associated with disease. An epidemiological study was conducted in two outbreak villages to investigate risk factors for developing illness. 76 patients were identified from 9 villages; 25% (19/76) died. Common presenting symptoms included vomiting, elevated liver enzymes, and altered mental status. In-depth interviews with 33 cases revealed that 31 (94%) had consumed ghagra shak, an uncultivated plant, in the hours before illness onset. Ghagra shak was consumed as a main meal by villagers due to inaccessibility of other foods following destructive monsoon flooding and rises in global food prices. Persons who ate this plant were 34.2 times more likely (95% CI 10.2 to 115.8, p-value<0.000) than others to develop vomiting and unconsciousness during the outbreak in our multivariate model. Ghagra shak is the local name for Xanthium strumarium, or common cocklebur.

Conclusions
The consumption of Xanthium strumarium seedlings in large quantities, due to inaccessibility of other foods, caused this outbreak. The toxic chemical in the plant, carboxyatratyloside, has been previously described and eating X. strumarium seeds and seedlings has been associated with fatalities in humans and livestock. Unless people are able to meet their nutritional requirements with safe foods, they will continue to be at risk for poor health outcomes beyond undernutrition.

Citation: Gurley ES, Rahman M, Hossain MJ, Nahar N, Faiz MA, et al. (2010) Fatal Outbreak from Consuming Xanthium strumarium Seedlings during Time of Food Scarcity in Northeastern Bangladesh. PLoS ONE 5(3): e9756. doi:10.1371/journal.pone.0009756

 

[Ronan Kelly]

Re: Bihar: Mysterious disease kills 48 children - undetermined encephalitis - samples negative for JE, Nipah and Chandipura

Re: Bihar: Mysterious disease kills 48 children - undetermined encephalitis - samples negative for JE, Nipah and Chandipura

Another Muzaffarpur child dies of brain fever

Priti Nath Jha, TNN | Jun 27, 2011, 05.00am IST
MUZAFFARPUR: Nature appears to have controlled the suspected encephalitis or brain fever here. A considerable relief from the sweltering heat following rain followed by cloudy weather has suddenly brought down the cases of the undiagnosed disease within the last 24 hours. Only one child died and only two fresh cases were admitted for treatment here since Saturday afternoon.
The head of paediatrics department of Shri Krishna Medical College and Hospital (SKMCH), Muzaffarpur, Dr Brajmohan informed on Sunday that the situation would further improve if the weather condition improves. Every child patient is suffering from lack of sodium due to excessive sweating, he said.

He said there was no death nor any fresh arrival of patient at SKMCH in the last 24 hours. Only eight patients were on the sick bed now, two of them in critical condition, he said. Kejriwal Hospital sources said that only one patient died in the wee hours on Sunday. Altogether nine patients were discharged on the day after successful treatment, whereas two new patients were admitted to the children's ward. Meanwhile, the five-member team of medical experts formed by DM Santosh Kumar Mall would hold its first meeting on Tuesday to fix a protocol on the mode of treatment to ensure an identical treatment to all patients. Convener of the team Dr Brajmohan informed that all the members of the team including the neurologist from Rajendra Memorial Research Institute (RMRI), Dr Krishna Pandey, another neurologist from Patna Dr Ashok Kumar Singh, local child specialist Dr Arun Shah and Kejriwal Hospital's paediatrics head Dr Rajiv Kumar have agreed to reach a consensus on the treatment pattern. Dr Brajmohan, however, added that he had given antiviral Acyclovir to one of the patients having symptoms of herpes. The DM has provided pumps to the malaria department through the municipal corporation to start fogging of malathion in the affected villages. The fogging was launched on Sunday which, according to a deadline fixed by the DM, would be completed in the next 21 days.

http://timesofindia.indiatimes.com/...d-dies-of-brain-fever/articleshow/9007855.cms

 

[Ronan Kelly]

Re: Bihar: Mysterious disease kills 48 children - undetermined encephalitis - samples negative for JE, Nipah and Chandipura

Re: Bihar: Mysterious disease kills 48 children - undetermined encephalitis - samples negative for JE, Nipah and Chandipura

Encephalitis ruled out by NIV; fever toll climbs to 45
PTI | 07:06 PM,Jun 27,2011

Muzaffarpur (Bihar), Jun 27 (PTI) One more children died today due to a mystery disease taking the fever toll to 45 in Bihar's Muzaffarpur district as the National Institute of Virology (NIV) ruled out encephalitis being the reason behind the deaths, officials said.One child died of the fever at Srikrishna Medical College Hospital here, they said.Twenty more children were undergoing treatment for encephalitis at SKMCH and Kejriwal hospitals in the district, they said.Meanwhile, scientists from NIV at Pune, in a report to district magistrate S K Mall have ruled out Japanese encephalitis (JE), Chandipura Virus encephalitis (JE), Nipah virus encephalitis in the nine samples it tested and requested the authorities to allow them to take brain tissue of patients suffering from this mystery disease.Mall had yesterday forwarded the request of the NIV scientists to the state government for necessary action, official sources said.Mall claimed the doctors were not unanimous over the treatment protocol of patients suffering this mystery disease.A central team which visited the hospitals here last week had clinically diagnosed the disease as encephalitis but remained tightlipped about the form of the encephalitis saying the blood samples sent to NIV in Pune would ascertain the kind of the disease, sources said.According to official sources, for allowing the experts to take brain tissue the state government would have to invoke the Epidemic Act, 1857 which provides the authority to take organ tissue of patients without having to seek consent of their guardians.Experts have also suggested massive spraying of methylene and DDT in the 63 affected villages of the district."At present, we are just doing symptomatic treatment of patients," Dr Braj Mohan, Head of Paediatrics at Srikrishna Medical College Hospital confided.

http://ibnlive.in.com/generalnewsfe...ut-by-niv-fever-toll-climbs-to-45/739846.html

 

[Ronan Kelly]

Re: Bihar: Mysterious disease kills 48 children - undetermined encephalitis - samples negative for JE, Nipah and Chandipura

Re: Bihar: Mysterious disease kills 48 children - undetermined encephalitis - samples negative for JE, Nipah and Chandipura

Mystery still shrouds the disease which has claimed more than 50 lives of children in Muzaffarpur district. Though, it was supposed to be encephalitis, which has now taken an endemic form, preliminary reports of National Institute of Virology (NIV), Pune, has cast doubts over it. Even the exact nature of virus has not been determined yet. The disease broke out on June 14.
http://timesofindia.indiatimes.com/speednewsshow/9016452.cms

 

[sharon sanders]

Re: Bihar: Mysterious disease kills 48 children - undetermined encephalitis - samples negative for JE, Nipah and Chandipura

Re: Bihar: Mysterious disease kills 48 children - undetermined encephalitis - samples negative for JE, Nipah and Chandipura

Mystery still shrouds the disease which has claimed more than 50 lives of children in Muzaffarpur district. Though, it was supposed to be encephalitis, which has now taken an endemic form, preliminary reports of National Institute of Virology (NIV), Pune, has cast doubts over it. Even the exact nature of virus has not been determined yet. The disease broke out on June 14.
http://timesofindia.indiatimes.com/speednewsshow/9016452.cms

I find this situation extremely odd. I hope the WHO and CDC are getting involved at this point.

 

[Ronan Kelly]

Re: Bihar: Mysterious disease kills 48 children - undetermined encephalitis - samples negative for JE, Nipah and Chandipura

Re: Bihar: Mysterious disease kills 48 children - undetermined encephalitis - samples negative for JE, Nipah and Chandipura

Brakes on imposing Epidemic Act
SUMI SUKANYA

Patna, June 27: Turning down the Muzaffarpur district administration?s proposal to invoke the Epidemic Act in the wake of the death of 42 children of a mystery disease, the state health department has directed the district officials to convince the parents of the deceased kids to allow conducting biopsy of their wards? brain tissues.

Sanjay Kumar, secretary, health department, said the state government at present was not in favour of segregating particular zones from where the cases of the disease were being reported.

?We have asked the district administration officials to convince the parents of the victims to allow conducting of biopsy on their brain tissues as it is very crucial for the disease investigation. We want parents? consent for the move rather than taking the brain tissues for examination by force,? Kumar told The Telegraph.

On if the government would invoke the act if the parents denied the permission to conduct biopsy, Kumar said the department would take a serious view of the proposal in that case.

He also said there was no final word from the National Institute of Virology (NIV), Pune, regarding the exact disease that had hit various blocks of Muzaffarpur, Motihari and Sheohar districts.

The senior officers in the health department said invoking the Epidemic Act would be the last resort. The situation was in control and number of cases was going down, an officer said.

The sources said only one patient was admitted to a hospital in Muzaffarpur today. ?Three-year-old Shahida, a resident of Chandu village in adjoining Vaishali district, was brought to Kejriwal Maternity Clinic today. She is undergoing treatment now,? a Muzaffarpur district administration official said.

A team comprising doctors from National Vector Borne Disease Programme, Pune, NIV, Pune, and few experts from Delhi was in Muzaffarpur to examine and investigate the mystery disease.

Forty-two kids have lost their lives so far owing to the disease whose symptoms are somewhat similar to Japanese encephalitis. Sources said district magistrate of Muzaffarpur Santosh Kumar Mall had sought permission from the state government to conduct biopsy of brain tissue of a child who had died of the mysterious disease on suggestions of the members of a central health team late on Saturday night and had suggested to invoke the Epidemic Act in the state.

The 1897 act provides special power to the state control and to prevent spread of an epidemic. The states may authorise any of its officers or agencies to take measures if the state feels that the public at large is threatened with an outbreak of any dangerous epidemic as per Section 2 of the Act. It also provides for the segregation of infected persons.

http://www.telegraphindia.com/1110628/jsp/bihar/story_14169098.jsp

 

[Ronan Kelly]

Re: Bihar: Mysterious disease kills 48 children - undetermined encephalitis - samples negative for JE, Nipah and Chandipura

Re: Bihar: Mysterious disease kills 48 children - undetermined encephalitis - samples negative for JE, Nipah and Chandipura

Muzaffarpur in grip of mystery disease
By Abhay Kumar

Strange as it may sound, despite the death of at least 42 children due to an outbreak of what?s presumed to be ?encephalitis? in Muzaffarpur district of Bihar in a matter of one week, doctors are still not sure what actually the mysterious disease is.


While some say the death took place due to heat-stroke, others say it was sun-stroke. Yet another section of doctors led by former Union health minister Dr C P Thakur argue that it could be because of the white small germ found in litchi fruit, which is mostly cultivated near Muzaffarpur.

When the situation became alarming, a central medical team was rushed there to stem the mystery disease. The central team comprised Dr B B Tandla and Dr C P Rawat of National Institute of Virology (NIV) Pune, Dr S K Jain of National Vector Brone Disease Control Programme, New Delhi, and an eminent paediatrician of Safdarjung Hospital Dr IP Choudhary.

Even though the team members collected samples of cerebrospinal fluids and blood serum, experts differ whether the killer disease is indeed encephalitis. The team from NIV, Pune, which conducted tests on four samples drawn from children affected by a mystery disease, has, on the basis of the samples received, ruled out Japanese encephalitis (JE).

?The NIV report which we have received, categorically says that no trace of JE was found in any of the samples,? said the director of the Rajendra Memorial Research Institute (RMRI) Dr Pradeep Das. However, experts argue that the report was based on blood serum samples and cerebrospinal fluids, which were inadequate to prove encephalitis.

Diagnosis of infection

One week after the outbreak of the mysterious disease, RMRI authorities had collected cerebrospinal fluids (CSF) and blood serum from the afflicted children and sent it to the NIV for diagnosis of the infection.

The doctors say that brain tissues were needed for examination to ascertain encephalitis. The only positive thing in the NIV report is that it has ruled out the possibility of the disease being caused by fruits like litchi, as no strain of the Nipah virus was seen in the samples.

It may be mentioned here that fruit bats of pteropodidae family are the natural host of the Nipah virus, which causes severe illness, characterised by inflammation of the brain (encephalitis) or respiratory diseases.

According to the report, the Chandipura virus, which shows symptoms similar to those of acute encephalitis was also not detected either in the cerebro-spinal fluids or the serum. Then what is the disease that took the lives of 42 children in the last few days? National Institute of Virology director Dr A C Mishra says that to identify the exact virus, the laboratory needed brain autopsy material of the patients affected, which was not made available by the Bihar government.

?Since the disease relates to the brain, we need brain tissues to arrive at any conclusion,? he said and added that cerebro-spinal fluids and blood serum samples would not suffice for diagnosing the disease.

Rise in death toll

It all began in the third week of June when nearly two dozen children were admitted to different hospitals in Muzaffarpur with symptoms of high temperature and convulsion. Initially, seven children died within a couple of days. But the death toll kept on rising with three-four children reportedly dying due to mysterious disease every day.

It was then that the central medical team was pressed into service. Intensive spraying of DDT was carried out. Affected villages were cordoned off and special immunisation drive launched by fogging mosquitoes and viral insects.

Even then, 29 children are still admitted in two hospitals including 21 in Kejriwal Hospital and eight in Sri Krishan Medical College and Hospital (SKMCH). Health minister Ashwini Choubey, who made an on-the-spot inspection, said Bihar government won?t leave the children in the lurch and would bear the expenses incurred by even those undergoing treatment in private hospitals.

Ashwini Choubey ruled out encephalitis but at the same time he was not sure what the mysterious disease actually is.

http://www.deccanherald.com/content/172007/muzaffarpur-grip-mystery-disease.html

 

[Ronan Kelly]

Re: Bihar: Mysterious disease kills 48 children - undetermined encephalitis - samples negative for JE, Nipah and Chandipura

Re: Bihar: Mysterious disease kills 48 children - undetermined encephalitis - samples negative for JE, Nipah and Chandipura

Changing the temperature of the mercury dropped to death Jun 28,

- Time series began to come out of the cheek
- Hospitals took in nine children by family breathe Cure
- Recruitment of doctors at children's eye, began studies on treatment

Muzaffarpur, Office report: the weather patterns change, the temperature of the child death rate has come down. Tuesday stopped - stopping the rain began, the number of patients seen at once. Skemsiac a patient enrolled in the two-Cure There were only nine patients. Kejriwal said hospital administrator wife fell over and the mercy of the enormous success of the efforts of physicians. In the hospital - dying of a village MOOSHAHARY Natasha, East Champaran Fenhara Alam Shnbaj of amethyst, of Madhopur Ahiapur Shorty, Blmi of Sahebganj Pikesh Kumar, Nusrat Cure and returned to Bahadurpur. The doctors discharged him in check. Skemsiac here four children admitted to the ICU ward number 2 in the Chamber on Monday sent the baby. Meenapurmanikpur in the mascara, the Neetu Ahiapur Mushri Bkri Pinky and the winning village of Chapra Ravi Kumar. Head of the hospital superintendent in charge of co-baby syndrome, Dr. Mohan said that all children have been recovered, which will be discharged from hospital on Tuesday. Child specialist Dr. Gopal Shankar Sahani, Dr. JP said the board due to the impact of the heat of the patient gradually will be reduced.
http://in.jagran.yahoo.com/news/local/bihar/4_4_7932223.html

 

[alert]

Re: Bihar: Mysterious disease kills 48 children - undetermined encephalitis - samples negative for JE, Nipah and Chandipura

Re: Bihar: Mysterious disease kills 48 children - undetermined encephalitis - samples negative for JE, Nipah and Chandipura

http://www.thehindu.com/news/states/other-states/article2142148.ece

Mystery fever toll climbs to 46 in Bihar

The fatal ?mystery fever? on Tuesday claimed one more life in Bihar?s Muzaffarpur district, taking the death toll to 46, even as ambiguity still prevails over the disease with scientists ruling out encephalitis.

Chief Medical Officer K P Singh said one more child died at Kejriwal hospital during the day.

Two more children were being treated at the Srikrishna Medical College Hospital and the Kejriwal hospital, he said.

A central team which visited the hospitals last week had initially diagnosed the disease as encephalitis and sent the blood samples to Pune?s National Institute of Virology for further tests.

NIV scientists, however, in a report to district magistrate S K Mall, ruled out Japanese encephalitis, Chandipura Virus encephalitis and Nipah virus encephalitis in the nine samples they tested.

As a precautionary measure, Methylene and DDT were being sprayed on a large-scale in the 63 affected villages, officials said.

?At present, we are just resorting to symptomatic treatment,? Dr Braj Mohan, Head of Paediatrics at the Srikrishna Medical College Hospital, said.

 

[Ronan Kelly]

Re: Bihar: Mysterious disease kills 48 children - undetermined encephalitis - samples negative for JE, Nipah and Chandipura

Re: Bihar: Mysterious disease kills 48 children - undetermined encephalitis - samples negative for JE, Nipah and Chandipura

Sadly the Press Trust of India agency report above was repeated verbatim in the Hindu, Deccan Herald and The Times of India indicating that the major english language dailies are no longer independently covering this story.

 

[Treyfish]

Re: Bihar: Mysterious disease kills 48 children - undetermined encephalitis - samples negative for JE, Nipah and Chandipura

Re: Bihar: Mysterious disease kills 48 children - undetermined encephalitis - samples negative for JE, Nipah and Chandipura

Full Muzaffarpur sick, the poor governance Babu

2 hours 42 minutes ago​

The arrogance of good governance on the issue of filling the power of the Nitish Kumar has already failed and is ineffective in terms of health. Polls opened Babu claims of good governance across the unknown disease in Muzaffarpur in Bihar's Muzaffarpur district in the past fortnight has taken the lives of 59 children.

Inseflaitis before the disease was believed to be Japanese, but all tests so far have not known the disease is found. Clearly, after so many innocent lives yet good governance Babu's government is proving to be useless in detecting disease.
Associated with the disease so far 62 samples have been sent to Pune's National Institute Wayroloji. These 22 samples have been checked. After investigation, experts have not yet confirmed by the Japanese Inseflaitis. Check the samples also showed that children are not suffering from NIEPA virus and Chandipura virus. The remaining 40 samples to check the work is still ongoing. Many samples have been sent to Pune, for instance - CSF (Spinal check), blood sample, and more. Reach the affected area in the living animal, bat and Mchcdon the blood sample is being analyzed.
Shri K. Mishra, Principal Secretary, Department of Health National Institute Wayroloji has sought help from the experts. The expert on your part are to provide all the help. Yet still the heart of the matter could not be reached.

Sample of brain tissue that can be checked to find out the disease, but the government has to declare the epidemic disease. Snr Act frightening and horrible plague epidemic in India in 1897 was designed to control. The Act gives powers to the government of the disease prevention with a sample of any part of the patient is likely to check it. The Act provides also that the suffering patient to prevent transmission of disease to be avoided and on the location - clean to be taken care of.

The district collector Santosh Kumar Mall of the State Chief Minister Nitish Kumar has sent a proposal to this effect. Mr. Malla believe that this unknown disease outbreak will be declared to understand the mystery of the disease.

Currently, Dr. Ashok Kumar, Dr. Krishna Kumar, Dr. Brij Mohan, Dr. Arun Shah and Dr. Rajiv Kumar, who specialize in infant as a team in the district are trying to fight the unknown disease. District Magistrate Santosh Kumar Mall from June 26 under the massive cleanup operation is being carried out in 63 affected villages. The sequence of B grade nurses and primary health centers in the designated area, particularly the development of the Seedeepio advised to keep an eye on. The series of these exercises as a sequel is being made to check the health of the elderly
.
Even if it was not yet the disease is unknown. But it can be fitted to the speculation that the disease is associated coil deep **** for sure, because so far have come from the patient Mushri. (Mushri called the place where people live Mushr caste) members of this nation's way of life is very dirty. Their main diet is the rat and pig meat.
It's basically your stomach and raise wages and Deshi Srab are sold.

?​

Here is the question that every district Prshasn water after passing through the top of the head comes into action, why? Planned and the administration will work with such an epidemic, we rarely have to face to face...

political story
:tiphat:http://translate.googleusercontent....8.html&usg=ALkJrhgTjcOe7hRbmTZqLimA20WGqidvjg

 

[Treyfish]

Re: Bihar: Mysterious disease kills 48 children - undetermined encephalitis - samples negative for JE, Nipah and Chandipura

Re: Bihar: Mysterious disease kills 48 children - undetermined encephalitis - samples negative for JE, Nipah and Chandipura

Meningitis his outstretched foot, a death


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Jun 28, 02:54 am​

Jun 28, 02:54 am

Muzaffarpur, Casn:
Case A: Hedge Tola village in East Champaran district resident Buln Gulmti Devi Thakur's wife was admitted for treatment Skemsiac on June 8. The doctors told him to be suffering from Janchonprant Menenjaitis. His death occurred during treatment. According to family members before her stomach was upset. In addition, she was vomiting and fever.

Case 2: Kanti police caught the seven-year-old daughter of the village residents face veil Suresh Kumari Menenjaitis was the victim of disability. He is now unable to stand. Situation remains serious. Geeta Devi, mother of the edge of the last seven days after the fever and pain is starting to shiver. Continue the treatment, the improvement is not satisfactory.

Case 3: Sitamarhi, police Prsuni the blank face of the three-year-old daughter Asha Kumari Harishchandra Krgi village have been admitted. Hope's mother Sunita Devi takes the first fever - seem close mobility. Now there is no voice.

Case 4: Sitamarhi Dumra Kethria village of Thane of the Board of TI's 10-year-old daughter was admitted to Miss Moonlight. According to the mother goddess Jnarasi fever had it before. Then felt a pain in the body. Now the shuttle - were all stopped talking. Is admitted to the Skemsiac. :tiphat:http://translate.googleusercontent....5.html&usg=ALkJrhgdZvl0tRooHfqrPjQ8rsCBpmyHFQ