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BMC Pediatr
. 2024 Jun 19;24(1):399.
doi: 10.1186/s12887-024-04882-0. Clinical characteristics and prognostic marker for hospitalization in children with influenza infection in an emergency setting
Rattapon Uppala 1 , Nattapon Seenoikhao 1 , Phanthila Sitthikarnkha 1 , Sirapoom Niamsanit 1 , Suchaorn Saengnipanthkul 1 , Leelawadee Techasatian 2 , Prapassara Sirikarn 3
Affiliations
Background: Influenza is a main cause of illnesses during seasonal outbreaks. Identifying children with influenza who may need hospitalization may lead to better influenza outcomes.
Objective: To identify factors associated with the severity of influenza infection, specifically among children who were admitted to the hospital after being diagnosed with influenza at the emergency department.
Methods: A retrospective cohort study was conducted among pediatric patients (age < 18 years) with a positive influenza rapid test who visited the emergency department at Srinagarind hospital between January2015-December2019. The dependent variable was hospital admission, while the independent variables included clinical parameters, laboratory results, and emergency severity index(ESI). The association between these variables and hospital admission was analyzed.
Results: There were 542 cases of influenza included in the study. The mean age was 7.50 ± 4.52 years. Males accounted for 52.4% of the cases. A total of 190(35.05%) patients, needed hospitalization. Patients with pneumonia, those who required hospitalization or were admitted to the critical care unit, consistently exhibited an elevated absolute monocyte count and a reduced lymphocyte-to-monocyte ratio (LMR). Various factors contribute to an increased risk for hospitalization, including ESI level 1-2, co-morbidity in patients, age < 1 year old, and an LMR below 2.
Conclusions: ESI level 1-2 and co-morbidity in patients represent significant risk factors that contribute to higher hospitalization admissions. A LMR below 2 can be used as a prognostic marker for hospitalization in children with influenza infection.
Keywords: Children; Hospital admission; Influenza; Prognostic marker; Risk factor.
. 2024 Jun 19;24(1):399.
doi: 10.1186/s12887-024-04882-0. Clinical characteristics and prognostic marker for hospitalization in children with influenza infection in an emergency setting
Rattapon Uppala 1 , Nattapon Seenoikhao 1 , Phanthila Sitthikarnkha 1 , Sirapoom Niamsanit 1 , Suchaorn Saengnipanthkul 1 , Leelawadee Techasatian 2 , Prapassara Sirikarn 3
Affiliations
- PMID: 38898404
- PMCID: PMC11186267
- DOI: 10.1186/s12887-024-04882-0
Background: Influenza is a main cause of illnesses during seasonal outbreaks. Identifying children with influenza who may need hospitalization may lead to better influenza outcomes.
Objective: To identify factors associated with the severity of influenza infection, specifically among children who were admitted to the hospital after being diagnosed with influenza at the emergency department.
Methods: A retrospective cohort study was conducted among pediatric patients (age < 18 years) with a positive influenza rapid test who visited the emergency department at Srinagarind hospital between January2015-December2019. The dependent variable was hospital admission, while the independent variables included clinical parameters, laboratory results, and emergency severity index(ESI). The association between these variables and hospital admission was analyzed.
Results: There were 542 cases of influenza included in the study. The mean age was 7.50 ± 4.52 years. Males accounted for 52.4% of the cases. A total of 190(35.05%) patients, needed hospitalization. Patients with pneumonia, those who required hospitalization or were admitted to the critical care unit, consistently exhibited an elevated absolute monocyte count and a reduced lymphocyte-to-monocyte ratio (LMR). Various factors contribute to an increased risk for hospitalization, including ESI level 1-2, co-morbidity in patients, age < 1 year old, and an LMR below 2.
Conclusions: ESI level 1-2 and co-morbidity in patients represent significant risk factors that contribute to higher hospitalization admissions. A LMR below 2 can be used as a prognostic marker for hospitalization in children with influenza infection.
Keywords: Children; Hospital admission; Influenza; Prognostic marker; Risk factor.