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Intern Med. 2018 Aug 24. doi: 10.2169/internalmedicine.1441-18. [Epub ahead of print]
Scleroderma Renal Crisis Complicated with Thrombotic Microangiopathy Triggered by Influenza B Virus Infection.
Shimizu T1, Iwamoto N1, Okamoto M1, Endo Y1, Tsuji S1, Takatani A1, Igawa T1, Umeda M1, Fukui S1, Sumiyoshi R1, Kitamura M2, Koga T1, Kawashiri SY1, Ichinose K1, Tamai M1, Nakamura H1, Origuchi T1,3, Nishino T2, Kawakami A1.
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Abstract
A 44-year-old Japanese man with a 14-year history of limited cutaneous systemic sclerosis (SSc) was admitted with a fever, hypertension, anemia, thrombocytopenia, and renal dysfunction. On admission, hypertension, hyperreninemia, acute renal dysfunction, hemolytic anemia, and thrombocytopenia led to the diagnosis of sclerotic renal crisis (SRC) complicated with thrombotic microangiopathy (TMA). The patient had also been infected with influenza B virus almost six days before admission. Following treatment with plasma exchange, an angiotensin-converting enzyme inhibitor, and an anti-virus agent, his general condition improved. He had no risk factors for SRC. In SSc patients, an influenza virus infection might trigger SRC complicated with TMA.
KEYWORDS:
SRC; SSc; TMA; influenza virus
PMID: 30146597 DOI: 10.2169/internalmedicine.1441-18
Free full text
Scleroderma Renal Crisis Complicated with Thrombotic Microangiopathy Triggered by Influenza B Virus Infection.
Shimizu T1, Iwamoto N1, Okamoto M1, Endo Y1, Tsuji S1, Takatani A1, Igawa T1, Umeda M1, Fukui S1, Sumiyoshi R1, Kitamura M2, Koga T1, Kawashiri SY1, Ichinose K1, Tamai M1, Nakamura H1, Origuchi T1,3, Nishino T2, Kawakami A1.
Author information
Abstract
A 44-year-old Japanese man with a 14-year history of limited cutaneous systemic sclerosis (SSc) was admitted with a fever, hypertension, anemia, thrombocytopenia, and renal dysfunction. On admission, hypertension, hyperreninemia, acute renal dysfunction, hemolytic anemia, and thrombocytopenia led to the diagnosis of sclerotic renal crisis (SRC) complicated with thrombotic microangiopathy (TMA). The patient had also been infected with influenza B virus almost six days before admission. Following treatment with plasma exchange, an angiotensin-converting enzyme inhibitor, and an anti-virus agent, his general condition improved. He had no risk factors for SRC. In SSc patients, an influenza virus infection might trigger SRC complicated with TMA.
KEYWORDS:
SRC; SSc; TMA; influenza virus
PMID: 30146597 DOI: 10.2169/internalmedicine.1441-18
Free full text