Tweet
Influenza Other Respir Viruses. 2017 Nov 16. doi: 10.1111/irv.12523. [Epub ahead of print]
Risk factors for seasonal influenza virus detection in stools of patients consulting in general practice for acute respiratory infections in France, 2014-2016.
Minodier L1, Masse S1, Capai L1, Blanchon T2,3, Ceccaldi PE4,5,6, van der Werf S5,7,8, Hanslik T9, Charrel NR10, Falchi A1.
Author information
Abstract
BACKGROUND:
Previous studies reported detection of influenza RNA in stools of patients with seasonal influenza infection. While this detection may have a clinical significance, other factors may influence the stools positivity for influenza viruses.
OBJECTIVES:
The objective of this study was to investigate demographical, clinical and microbiological factors which could favour the presence of influenza viral RNA in the stools of patients with laboratory-confirmed influenza infection.
METHODS:
Acute respiratory infection (ARI) patients were enrolled by general practitioners (GP) during two winter seasons (2014-2016). Nasopharyngeal swabs, stool specimens and clinical data were collected. Samples were tested for 12 respiratory pathogen groups (nasopharyngeal and stool specimens) and for 12 enteric pathogens (stool specimens).
RESULTS:
Among the 331 patients with ARI enrolled by GP, 114 (34.4%) presented influenza infection. Influenza RNA was detected in stool samples of 21% (24/114) of the 114 stool specimens analysed. Hospitalization [adjusted odds ratio(aOR)=7.8 (95% confidence interval (CI) [1.7-33.7], p=0.02), age between 45-64 years (aOR = 4.8 [1.7-14.5], p=0.01), consumption of raw shellfish and/or molluscs (aOR = 16.7 [3.6-90.9], p=0.00), and use of antibiotics (aOR = 6.4 [2.1-19.8], p=0.006) or antiviral treatment (aOR = 7.4 [1.9-29], p=0.01) were significantly associated with an increased odds of the detection of influenza RNA in stools. Among the 24 stool samples subjected to viral isolation, no one showed virus growth.
CONCLUSIONS:
These findings will be useful to studies investigating the dissemination route of influenza viruses to gastrointestinal tract. This article is protected by copyright. All rights reserved.
This article is protected by copyright. All rights reserved.
KEYWORDS:
Acute Respiratory Infection; Enteric Pathogens; Gastrointestinal Symptoms; General Practitioner; Influenza Virus; Stool samples
PMID: 29144593 DOI: 10.1111/irv.12523
Free full text
Risk factors for seasonal influenza virus detection in stools of patients consulting in general practice for acute respiratory infections in France, 2014-2016.
Minodier L1, Masse S1, Capai L1, Blanchon T2,3, Ceccaldi PE4,5,6, van der Werf S5,7,8, Hanslik T9, Charrel NR10, Falchi A1.
Author information
Abstract
BACKGROUND:
Previous studies reported detection of influenza RNA in stools of patients with seasonal influenza infection. While this detection may have a clinical significance, other factors may influence the stools positivity for influenza viruses.
OBJECTIVES:
The objective of this study was to investigate demographical, clinical and microbiological factors which could favour the presence of influenza viral RNA in the stools of patients with laboratory-confirmed influenza infection.
METHODS:
Acute respiratory infection (ARI) patients were enrolled by general practitioners (GP) during two winter seasons (2014-2016). Nasopharyngeal swabs, stool specimens and clinical data were collected. Samples were tested for 12 respiratory pathogen groups (nasopharyngeal and stool specimens) and for 12 enteric pathogens (stool specimens).
RESULTS:
Among the 331 patients with ARI enrolled by GP, 114 (34.4%) presented influenza infection. Influenza RNA was detected in stool samples of 21% (24/114) of the 114 stool specimens analysed. Hospitalization [adjusted odds ratio(aOR)=7.8 (95% confidence interval (CI) [1.7-33.7], p=0.02), age between 45-64 years (aOR = 4.8 [1.7-14.5], p=0.01), consumption of raw shellfish and/or molluscs (aOR = 16.7 [3.6-90.9], p=0.00), and use of antibiotics (aOR = 6.4 [2.1-19.8], p=0.006) or antiviral treatment (aOR = 7.4 [1.9-29], p=0.01) were significantly associated with an increased odds of the detection of influenza RNA in stools. Among the 24 stool samples subjected to viral isolation, no one showed virus growth.
CONCLUSIONS:
These findings will be useful to studies investigating the dissemination route of influenza viruses to gastrointestinal tract. This article is protected by copyright. All rights reserved.
This article is protected by copyright. All rights reserved.
KEYWORDS:
Acute Respiratory Infection; Enteric Pathogens; Gastrointestinal Symptoms; General Practitioner; Influenza Virus; Stool samples
PMID: 29144593 DOI: 10.1111/irv.12523
Free full text