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Eur J Pediatr. 2017 Jan 21. doi: 10.1007/s00431-017-2856-5. [Epub ahead of print]
Occurrence of atypical HUS associated with influenza B.
van Hoeve K1, Vandermeulen C2, Van Ranst M3, Levtchenko E4,5, van den Heuvel L5, Mekahli D4,5.
Author information
Abstract
Hemolytic uremic syndrome (HUS) is a disease characterized by thrombotic microangiopathy with a triad of non-immune hemolytic anemia, thrombocytopenia, and renal impairment. Approximately 10% of cases of HUS are classified as atypical (aHUS). While today many genetically forms of aHUS pathology are known, only about 50% of carriers precipitate the disease. The reason remains unclear, and triggering events like intercurrent infections have been postulated. In rare cases, influenza A is the known trigger of aHUS; however, no cases of influenza B have been reported.
CONCLUSION:
We describe for the first time that influenza B strain as a trigger for aHUS in children with primary hereditary forms. We also showed in our three cases that immunization appears to be safe; however, this needs to be confirmed in a larger cohort. What is Known: ? Known triggers of aHUS are infectious specimen. ? Influenza A-associated aHUS cases are rarely published. What is New: ? aHUS can be triggered by influenza B virus infection. ? Influenza vaccination of patients with aHUS appears safe.
KEYWORDS:
Atypical hemolytic uremic syndrome; Hemolytic uremic syndrome; Influenza B; Vaccination
PMID: 28110418 DOI: 10.1007/s00431-017-2856-5
[PubMed - as supplied by publisher]
Occurrence of atypical HUS associated with influenza B.
van Hoeve K1, Vandermeulen C2, Van Ranst M3, Levtchenko E4,5, van den Heuvel L5, Mekahli D4,5.
Author information
Abstract
Hemolytic uremic syndrome (HUS) is a disease characterized by thrombotic microangiopathy with a triad of non-immune hemolytic anemia, thrombocytopenia, and renal impairment. Approximately 10% of cases of HUS are classified as atypical (aHUS). While today many genetically forms of aHUS pathology are known, only about 50% of carriers precipitate the disease. The reason remains unclear, and triggering events like intercurrent infections have been postulated. In rare cases, influenza A is the known trigger of aHUS; however, no cases of influenza B have been reported.
CONCLUSION:
We describe for the first time that influenza B strain as a trigger for aHUS in children with primary hereditary forms. We also showed in our three cases that immunization appears to be safe; however, this needs to be confirmed in a larger cohort. What is Known: ? Known triggers of aHUS are infectious specimen. ? Influenza A-associated aHUS cases are rarely published. What is New: ? aHUS can be triggered by influenza B virus infection. ? Influenza vaccination of patients with aHUS appears safe.
KEYWORDS:
Atypical hemolytic uremic syndrome; Hemolytic uremic syndrome; Influenza B; Vaccination
PMID: 28110418 DOI: 10.1007/s00431-017-2856-5
[PubMed - as supplied by publisher]