Tweet
Microbiol Spectr
. 2023 Dec 1:e0260923.
doi: 10.1128/spectrum.02609-23. Online ahead of print. The ER-Golgi transport of influenza virus through NS1-Sec13 association during virus replication
Sonja C J H Chua 1 2 3 4 5 , Jianzhou Cui 1 2 3 , Karishma Sachaphibulkij 1 2 3 , Isabelle Siang Ling Tan 1 2 3 , Hui Qing Tan 1 2 3 , Hong Meng Lim 1 2 3 , David Engelberg 4 5 6 , Lina H K Lim 1 2 3
Affiliations
Influenza A virus is a respiratory virus that can cause complications such as acute bronchitis and secondary bacterial pneumonia. Drug therapies and vaccines are available against influenza, albeit limited by drug resistance and the non-universal vaccine administration. Hence there is a need for host-targeted therapies against influenza to provide an effective alternative therapeutic target. Sec13 was identified as a novel host interactor of influenza. Endoplasmic reticulum-to-Golgi transport is an important pathway of influenza virus replication and viral export. Specifically, Sec13 has a functional role in influenza replication and virulence.
Keywords: COPII; H1N1; H3N2; Sec13; influenza; non-structural protein 1 (NS1).
. 2023 Dec 1:e0260923.
doi: 10.1128/spectrum.02609-23. Online ahead of print. The ER-Golgi transport of influenza virus through NS1-Sec13 association during virus replication
Sonja C J H Chua 1 2 3 4 5 , Jianzhou Cui 1 2 3 , Karishma Sachaphibulkij 1 2 3 , Isabelle Siang Ling Tan 1 2 3 , Hui Qing Tan 1 2 3 , Hong Meng Lim 1 2 3 , David Engelberg 4 5 6 , Lina H K Lim 1 2 3
Affiliations
- PMID: 38038453
- DOI: 10.1128/spectrum.02609-23
Influenza A virus is a respiratory virus that can cause complications such as acute bronchitis and secondary bacterial pneumonia. Drug therapies and vaccines are available against influenza, albeit limited by drug resistance and the non-universal vaccine administration. Hence there is a need for host-targeted therapies against influenza to provide an effective alternative therapeutic target. Sec13 was identified as a novel host interactor of influenza. Endoplasmic reticulum-to-Golgi transport is an important pathway of influenza virus replication and viral export. Specifically, Sec13 has a functional role in influenza replication and virulence.
Keywords: COPII; H1N1; H3N2; Sec13; influenza; non-structural protein 1 (NS1).