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Interplay between Influenza Virus and the Host RNA Polymerase II Transcriptional Machinery

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  • Interplay between Influenza Virus and the Host RNA Polymerase II Transcriptional Machinery

    Trends Microbiol. 2019 Jan 11. pii: S0966-842X(18)30289-0. doi: 10.1016/j.tim.2018.12.013. [Epub ahead of print]
    Interplay between Influenza Virus and the Host RNA Polymerase II Transcriptional Machinery.

    Walker AP1, Fodor E2.
    Author information

    Abstract

    The influenza virus RNA-dependent RNA polymerase (RdRP) cleaves the 5' end of nascent capped host RNAs and uses the capped RNA fragment to prime viral transcription in a mechanism called 'cap snatching'. Cap snatching requires an intimate association between influenza RdRP and cellular RNA polymerase II (Pol II), which is the source of nascent capped host RNAs targeted by influenza virus. Recent structural studies have revealed how influenza RdRP binds to Pol II and how this binding promotes the initiation of viral transcription by influenza RdRP. In this review we focus on these recent insights into the mechanism of cap snatching by influenza virus and the impact of cap snatching on host gene expression during influenza virus infection.
    Copyright 2019 The Authors. Published by Elsevier Ltd.. All rights reserved.


    KEYWORDS:

    CTD; Pol II; RNA polymerase; cap snatching; influenza virus

    PMID: 30642766 DOI: 10.1016/j.tim.2018.12.013
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