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J Virol. 2012 Mar 14. [Epub ahead of print]
Abortive Replication of Influenza Virus in Mouse Dendritic Cells.
Ioannidis LJ, Verity EE, Crawford S, Rockman SP, Brown LE.
Source
Department of Microbiology and Immunology, University of Melbourne, Parkville 3010, Victoria, Australia.
Abstract
The interaction between influenza virus and dendritic cells (DCs) remains poorly defined and controversial. Herein, we show that influenza virus replication in murine bone marrow-derived DCs (BmDCs) is abortive, despite viral genome transcription and replication occurring for each gene segment and viral hemagglutinin and nucleoprotein at least, being produced. Electron microscopy reveals that assembly, rather than release of virus from the cell surface, is defective.
PMID:
22419813
[PubMed - as supplied by publisher]
Abortive Replication of Influenza Virus in Mouse Dendritic Cells.
Ioannidis LJ, Verity EE, Crawford S, Rockman SP, Brown LE.
Source
Department of Microbiology and Immunology, University of Melbourne, Parkville 3010, Victoria, Australia.
Abstract
The interaction between influenza virus and dendritic cells (DCs) remains poorly defined and controversial. Herein, we show that influenza virus replication in murine bone marrow-derived DCs (BmDCs) is abortive, despite viral genome transcription and replication occurring for each gene segment and viral hemagglutinin and nucleoprotein at least, being produced. Electron microscopy reveals that assembly, rather than release of virus from the cell surface, is defective.
PMID:
22419813
[PubMed - as supplied by publisher]
