France - Monkeypox outbreak 2022-2025

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Source: https://whbl.com/2022/05/19/france-s...-paris-region/

France says first suspected case of monkeypox detected in Paris region
By Syndicated Content
May 19, 2022 | 2:27 PM

PARIS (Reuters) – A first suspected case of the monkeypox virus on French territory has been detected in the Paris/Ile-de-France region, the French Health Ministry said on Thursday, amid signs of the virus’ spreading around the world..

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Monkeypox: information for healthcare professionals

published on 19.05.22

Actions to be taken by health professionals in front of a person likely to be affected: diagnosis, care, declaration, etc.

Several cases of autochthonous Monkeypox (MKP) infections have recently been reported in several European countries, from the United Kingdom, Portugal, Spain and Sweden, particularly in men who have sex with men ( MSM). Suspicious cases are being investigated in many countries. This is an unusual phenomenon. A first suspected case was reported today in Ile-de-France.

For all confirmed cases, analyzes revealed a virus belonging to the "West Africa" clade of the MKP virus, suggesting an initial link with Nigeria, a country in which the virus has been circulating regularly since 2017. case reported in the United Kingdom on May 7 imported from Nigeria, the new cases reported do not report travel to Africa or link to a person returning from Africa. At this stage, the reported cases are mostly mild, and there are no reported deaths.

After an incubation period that can range from 5 to 21 days , the infection begins with fever, headache, muscle pain and asthenia. The disease also causes lymph nodes. Lymph nodes (neck, face, etc.) are bulky. The person is contagious as soon as the first symptoms appear.

Within 1-3 days (sometimes longer) of the onset of fever, the patient develops a rash, which often begins on the face and then may spread to other parts of the body, including the palms of the hands, the soles of the feet and the genitals. The other mucous membranes (ENT, conjunctiva) may also be affected. It should be noted that recently detected cases among MSM have reported a preponderance of lesions in the genital area. Skin involvement occurs in a single push. The lesions pass through different successive stages (macule, papule, vesicle, pustule then crust), and evolve uniformly. When the scabs fall off, people are no longer contagious. The illness usually lasts 2 to 3 weeks.

The cutaneous involvement of Monkeypox infection differs from that of chickenpox (uncommon in adults). For chickenpox, the rash evolves into multiple flare-ups. The palms of the hands and the soles of the feet are spared.

Transmission of the Monkeypo x virus occurs when a person comes into contact with an animal (especially rodents), a human being or materials contaminated with the virus. The virus enters the body through a lesion of the skin (even if not visible), of the respiratory tract or of the mucous membranes. Transmission from animals to humans can occur by biting or scratching, by preparing bushmeat, by direct or indirect contact with bodily fluids or lesion material. Reservoir animals are not usually present in Europe.

Human-to- human transmission can occur through respiratory droplets, which usually cannot travel more than a few meters, requiring prolonged face-to-face contact. Other modes of human-to-human transmission include direct skin contact with body fluids or the lesion, and indirect contact with the lesion, such as through contaminated clothing, linens, or dishes.

In this context, vigilance is required in the face of any suggestive case.
As a reminder, Monkeypox infection is a notifiable disease in the same way as other orthopoxviruses. Any suspected case should be reported immediately to the Regional Health Agency in your area.


Santé publique France has developed a case definition and guidelines for tracing contact persons. The national COREB mission (Operational Coordination Epidemic and Biological Risk) has also drawn up a
reflex sheet for the medical management of cases and the protective measures to be adopted.

Consult the DGS-Urgent message of May 19, 2022


https://solidarites-sante.gouv.fr/so...nnels-de-sante

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European cases of Monkeypox: implementation of enhanced surveillance

Cases of Monkeypox not directly linked to travel to Central or West Africa or people returning from travel have been reported in the UK, Portugal, USA, suspected cases are being assessed in many countries and the situation is therefore changing very rapidly. In France, infections by these viruses are subject to long-term surveillance by means of compulsory notification. Given the European alerts in progress, the surveillance of these infections is reinforced by Public Health France and information and alert messages are sent to health professionals.

Posted May 19, 2022


To download

• Case definition and course of action

Case of Monkeypox: update in Europe and surveillance in France

Health authorities in the United Kingdom have notified 9 confirmed cases of Monkeypox in people who have not traveled to an area usually at risk (Central or West Africa) and do not report a link with people who have traveled to these areas. These cases therefore acquired their infection on British national territory. The virological analyzes of these 9 cases reveal a Monkeypox virus belonging to the West African viral clade. The first three cases were diagnosed on May 13, 2022, in a baby and his parents. The 6 other cases, diagnosed later, have no epidemiological link with the first two cases.

In addition, Portugal notified, on May 13, 2022, 5 confirmed cases infected with the Monkeypox virus, and 15 additional suspected cases are under investigation. These 20 cases concern men, mostly young.

To date, these cases have occurred mainly, but not exclusively, in men who have sex with men (MSM), with no direct links to people returning from endemic areas.

In the usual absence of Monkeypox in Europe and of a link reported by the cases identified with a risk zone, the current European context constitutes an alert and suggests contamination in Europe. This is why, in France, the long-term monitoring of Monkeypox by the mandatory reporting system is reinforced and information and alert messages are sent to health professionals . Exchanges are also continuing with other European countries, the WHO and the ECDC.

What is Monkeypox?

Monkeypox is an infectious disease caused by an othopoxvirus. This zoonotic disease is usually transmitted to humans in forest areas of Central and West Africa by wild rodents or primates, but human-to-human transmission is also possible, particularly within the family home or in the care setting.

How is it transmitted?

The monkeypox virus can be transmitted by direct contact with skin lesions or mucous membranes of a sick person, as well as by droplets (saliva, sneezing, sputters, etc.). You can also become contaminated through contact with the patient's environment (bedding, clothes, dishes, bath linen, etc.). It is therefore important that the patients observe isolation throughout the duration of the disease (until the disappearance of the last scabs, most often 3 weeks).

In Central or West Africa, humans can also become infected through contact with animals, wild or in captivity, dead or alive, such as rodents or monkeys.

MKP virus infection is not known as an STI, but direct contact with damaged skin during sexual intercourse facilitates transmission.

What are the symptoms ?

Monkeypox virus infection begins with a fever, often high and accompanied by headaches, body aches and fatigue. After about 2 days, a blistering rash appears, made up of fluid-filled blisters that progress to drying out, scab formation and then scarring. Itching is common. The bubbles are more concentrated on the face, the palms of the hands and the soles of the feet. The mucous membranes are also affected, in the mouth and the genital area. The lymph nodes are swollen and painful, under the jaw and in the neck.

The incubation of the disease can range from 5 to 21 days. The fever phase lasts about 1 to 3 days. The disease usually heals spontaneously, after two to three weeks.

Is monkeypox serious?

The disease is more severe in children and in immunocompromised people. It can be complicated by superinfection of the skin lesions or by respiratory, digestive or ophthalmological or neurological disorders.

At this stage, the cases reported in Europe are mostly mild, and there are no reported deaths.


https://www.santepubliquefrance.fr/l...ance-renforcee

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A first confirmed case of Monkeypox on national territory

A first case of infection with the Monkeypox virus was confirmed on May 19, 2022 in Ile-de-France. As soon as his infection was suspected, this person was taken care of. In the absence of gravity, she is isolated in her home.

Posted May 20, 2022



Press contacts

Directorate General for Health
presse-dgs@sante.gouv.fr
01 40 56 84 00
Public health France
presse@santepubliquefrance.fr
Stéphanie Champion: 01 41 79 67 48
Marie Delibéros: 01 41 79 69 61
Charlène Charbuy: 01 41 79 68 64
Cynthia Bessarion: 01 71 80 15 66


He is a 29-year-old man with no history of travel to a country where the virus is circulating.

An in-depth epidemiological investigation is carried out by teams from Public Health France and ARS Ile-de-France, in conjunction with the doctor who treated this person.

The people who have been in close contact with this patient are currently being identified. They will receive information from the health authorities on what to do in order to limit the spread of the virus.

Since May 14, 2022, confirmed cases of Monkeypox virus infection not directly linked to travel to Central or West Africa have been reported in several countries in Europe, United Kingdom, Portugal, Spain , Sweden, Italy, as well as the United States and Canada. Suspected cases are being assessed in many countries and the situation is changing rapidly.

In France, infections by orthopoxviruses, including Monkeypox, are subject to long-term monitoring by means of compulsory reporting. Given the current alerts, surveillance of these infections is being reinforced by Public Health France and recommendations have been sent to health professionals by the ministry.

What are the symptoms ?

Monkeypox virus infection begins with a fever, often high and accompanied by headaches, body aches and fatigue. After about 2 days, a blistering rash appears in a single push, made up of fluid-filled blisters that progress to drying out, crusting and then scarring. Itching is common. The bubbles are more concentrated on the face, the palms of the hands and the soles of the feet. The mucous membranes are also affected, in the mouth and the genital area. The lymph nodes are swollen and painful, under the jaw and in the neck.

The incubation of the disease can range from 5 to 21 days. The fever phase lasts about 1 to 3 days. The disease, generally benign, most often heals spontaneously, after 2 to 3 weeks.

How is it transmitted?

The Monkeypox virus can be transmitted by direct contact with lesions on the skin or mucous membranes of a sick person, as well as by droplets (saliva, sneezing, sputter, etc.). You can also become contaminated through contact with the patient's environment (bedding, clothes, dishes, bath linen, etc.). It is therefore important that the patients observe isolation throughout the duration of the disease (until the disappearance of the last scabs, most often 3 weeks).

What to do in case of symptoms?

If symptoms appear (fever and rash with blisters), contact the SAMU Center 15 who can direct you to a medical consultation.
It is recommended that you isolate yourself while waiting for medical advice and avoid contact with other people.

https://www.santepubliquefrance.fr/p...toire-national

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Source: https://www.bignewsnetwork.com/news/...ance-rise-to-3

Monkeypox cases in France rise to 3
Xinhua
24th May 2022, 20:49 GMT+10

PARIS, May 24 (Xinhua) -- The French Public Health Agency reported two new cases of monkeypox in the country on Monday.

France's first case was reported on May 20. The patient did not travel to any other country that had registered monkeypox cases recently.

The Public Health Agency noted that the three cases have not any direct link with people coming back from countries with confirmed monkeypox cases...

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Case of Monkeypox: update on May 23, 2022

Update on 05/23/22 following cases of Monkeypox virus infections reported in France and around the world.

Posted May 23, 2022
...
Cases of Monkeypox not directly linked to travel to Central or West Africa or people returning from travel have been reported in Europe and around the world, suspected cases are being assessed in many countries and the situation is therefore changing very rapidly. In France, infections by these viruses are subject to long-term surveillance by means of compulsory reporting. Given the current alerts, surveillance of these infections is reinforced by Public Health France and information and alert messages are sent to healthcare professionals.

Case of Monkeypox: update in France

As of May 23, 2022 at 2 p.m., 3 confirmed cases of Monkeypox have been reported in France.

To date, in Europe, these cases have occurred mainly, but not exclusively, in men who have sex with men (MSM), with no direct link to people returning from endemic areas.
'
In the usual absence of Monkeypox in Europe and of a link reported by the cases identified with a risk zone, the current European context constitutes an alert and suggests contamination in Europe. This is why, in France, the long-term surveillance of Monkeypox by the mandatory reporting system is reinforced and information and alert messages are sent to health professionals. Exchanges are also continuing with other European countries, the WHO and the ECDC.

...

https://www.santepubliquefrance.fr/les-actualites/2022/cas-de-monkeypox-point-de-situation-au-23-mai-2022

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Monkey pox: a first case diagnosed in Lyon

Published on 05/24/2022 at 12:43 p.m. • Updated 05/24/2022 at 12:54 p.m.
Written by AM

According to our sources, a first case of monkeypox was diagnosed in Lyon at the Croix Rousse hospital. A man was taken care of on Sunday May 22 and isolated, once confirmed, he would be the 4th case in France.

A man returning from the Canary Islands was reportedly diagnosed with monkeypox virus in Lyon.

Supported by teams from the Croix Rousse hospital, according to the protocol in place, he was isolated and would therefore be the 4th case recorded in France.

For the time being, neither the Hospices Civils de Lyon nor the Regional Health Agency have confirmed this information.

According to Public Health France "In France, infections by these viruses are subject to long-term surveillance through the mandatory notification system. Cases of monkey pox not directly linked to a trip to Central or South Africa West or people returning from travel have been reported in Europe and around the world, suspected cases are being assessed in many countries and the situation is therefore evolving very quickly."
...

https://france3-regions.francetvinfo.fr/variole-du-singe-un-premier-cas-diagnostique-a-lyon-2548516.html

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Case of Monkeypox: update on May 24, 2022

Update on 05/24/22 following cases of Monkeypox virus infections reported in France and around the world.

Posted May 24, 2022
...
Cases of Monkeypox not directly linked to travel to Central or West Africa or people returning from travel have been reported in Europe and around the world, suspected cases are being assessed in many countries and the situation is therefore changing very rapidly. In France, infections by this virus are subject to long-term surveillance by means of compulsory reporting. Given the current alerts, surveillance of these infections is reinforced by Public Health France and information and alert messages are sent to healthcare professionals.

Case of Monkeypox: update in France

As of 24 May 2022 at 2 p.m., 5 confirmed cases of Monkeypox have been reported in France (Source: SpFrance): 3 in Ile-de-France, 1 in Auvergne-Rhône-Alpes and 1 in Occitanie.

To date, in Europe, these cases have occurred mainly, but not exclusively, in men who have sex with men (MSM), with no direct link to people returning from endemic areas.

In the usual absence of Monkeypox in Europe and of a link reported by the cases identified with a risk zone, the current European context constitutes an alert and suggests contamination in Europe. This is why, in France, the long-term monitoring of Monkeypox by the mandatory reporting system is reinforced and information and alert messages are sent to health professionals . Exchanges are also continuing with other European countries, the WHO and the ECDC.

...

https://www.santepubliquefrance.fr/les-actualites/2022/cas-de-monkeypox-point-de-situation-au-24-mai-2022

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Monkeypox: vaccinating adults and healthcare professionals after exposure to the disease



PRESS RELEASE - Posted on May 24 2022


May 24, 2022

The appearance of cases of Monkeypox , in several countries, particularly in Europe, and the confirmation of three cases in France, led the General Directorate of Health to urgently contact the HAS in order to specify the vaccination strategy to be implemented to reduce human-to-human transmission of the virus. HAS now recommends the implementation of a reactive vaccination strategy, i.e. around a confirmed case: adults whose contact with an infected person is considered to be at risk, including professionals health exposed without individual protection measures. This vaccination should be performed only with the third generation vaccine.

Requested urgently by the Director General of Health, the HAS has drawn up an opinion in order to specify the vaccination strategy to be implemented in order to limit the transmission of Monkeypox . Thus, HAS considers that a reactive vaccination strategy seems relevant given the incubation times of the disease, often between 6 and 16 days, but also that the vaccination strategy adopted in other European countries and the preclinical data transmitted by the National Agency for the Safety of Medicines and Health Products (ANSM) which, although preliminary and limited, support the interest of vaccination quickly after exposure to the virus.

The HAS recommends the implementation of a reactive vaccine strategy in post-exposure with the 3rd generation vaccine only (in view of its ^safety profile, better than that of the 1st ^{and 2nd} generation vaccines and its efficacy [1] ), ideally administered within 4 days after the risky contact and at most 14 days later with a two-dose regimen (or three doses in immunocompromised subjects), spaced 28 days apart, for the following cases:

• Adult contact persons at risk of exposure to Monkeypox as defined by Public Health France [2] , including health professionals exposed without personal protective measures [3] ;

This strategy must be put in place as soon as a case of infection is identified following an investigation by the ARS and the regional unit of Public Health France.
HAS will adapt this preliminary recommendation according to the new epidemiological and clinical data available and emphasizes the importance of soon having:

• more precise data on the mode of human-to-human transmission for currently identified cases;
• epidemic monitoring data;
• additional real-life data relating to the efficacy and tolerance of the 3 rd generation smallpox vaccine ^, administered pre-exposure and post-exposure to the Monkeypox virus , on the prevention of severe forms and on the transmission of the disease;
• data on the efficacy and safety of a booster dose in people who were vaccinated against smallpox in childhood.

Finally, HAS would like to emphasize that, in the current epidemic context, it is essential to adopt personal prevention and protection measures [4] beyond the reinforced measures for identifying and monitoring cases (screening, identification contacts, isolation of cases) and the recommended vaccination strategy.

HAS also indicates that the proposed vaccine strategy is part of a more global management strategy including in particular the provision of antiviral treatments not evaluated by HAS but with Marketing Authorization in the Monkeypox indication , in particular for eligible children, for whom the 3rd generation vaccine ^does not currently benefit from MA.

The response to this referral is part of a broader reflection on the revision of the doctrine for combating a possible re-emergence of orthopoxviruses.

HAS is continuing its scientific monitoring work and will adapt its recommendations accordingly.

Find the full opinion of the HAS

[1] ANSM in response to the ministerial referral on the Monkeypox response plan dated May 18, 2022
[2]https://www.santepubliquefrance.fr/media/files/ Maladies-a-declaration-obligatoire/definition-de-cas -cat-monkeypox [3] Protection measures as defined by the HCSP [4] The specific protection measures will be specified in an opinion from the HCSP in the coming days




https://www.has-sante.fr/jcms/p_3340...n-a-la-maladie

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Case of Monkeypox: update as of May 25, 2022

Update on 05/25/22 following cases of Monkeypox virus infections reported in France and around the world.

Posted May 25, 2022

...

Cases of Monkeypox not directly linked to travel to Central or West Africa or people returning from travel have been reported in Europe and around the world, suspected cases are being assessed in many countries and the situation is therefore changing very rapidly. In France, infections by this virus are subject to long-term surveillance by means of compulsory reporting. Given the current alerts, surveillance of these infections is reinforced by Public Health France and information and alert messages are sent to healthcare professionals.

Case of Monkeypox: update in France

As of May 25, 2022 at 6 p.m., 7 confirmed cases of Monkeypox have been reported in France (Source: SpFrance): 4 in Ile-de-France, 1 in Auvergne-Rhône-Alpes, 1 in Occitanie and 1 in Normandy.

To date, in Europe, these cases have occurred mainly, but not exclusively, in men who have sex with men (MSM), with no direct link to people returning from endemic areas.

In the usual absence of Monkeypox in Europe and of a link reported by the cases identified with a risk zone, the current European context constitutes an alert and suggests contamination in Europe. This is why, in France, the long-term monitoring of Monkeypox by the mandatory reporting system is reinforced and information and alert messages are sent to health professionals . Exchanges are also continuing with other European countries, the WHO and the ECDC.

...

https://www.santepubliquefrance.fr/les-actualites/2022/cas-de-monkeypox-point-de-situation-au-25-mai-2022

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Source: https://www.santepubliquefrance.fr/l...au-27-mai-2022


Case of Monkeypox: update in France

As of 27 May 2022 at 2 p.m., 7 confirmed cases of Monkeypox have been reported in France (Source: SpFrance): 4 in Ile-de-France, 1 in Auvergne-Rhône-Alpes, 1 in Occitanie and 1 case in Normandy. The next update will take place on Monday, May 30.

To date, in Europe, these cases have occurred mainly, but not exclusively, in men who have sex with men (MSM), with no direct link to people returning from endemic areas.

In the usual absence of Monkeypox in Europe and of a link reported by the cases identified with a risk area, the current European context constitutes an alert and suggests contamination in Europe. This is why, in France, the long-term surveillance of Monkeypox by the mandatory reporting system is reinforced and information and alert messages are sent to health professionals. Exchanges are also continuing with other European countries, the WHO and the ECDC...

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Source: https://www.santepubliquefrance.fr/l...au-28-mai-2022


Case of Monkeypox: update in France

As of 28 May 2022 at 2 p.m., 16 confirmed cases of Monkeypox have been reported in France (Source: SpFrance): 12 in Ile-de-France, 1 in Auvergne-Rhône-Alpes and 2 in Occitanie and 1 case in Normandy. The next update will take place on Monday, May 30.

To date, in Europe, these cases have occurred mainly, but not exclusively, in men who have sex with men (MSM), with no direct link to people returning from endemic areas.

In the usual absence of Monkeypox in Europe and of a link reported by the cases identified with a risk area, the current European context constitutes an alert and suggests contamination in Europe. This is why, in France, the long-term surveillance of Monkeypox by the mandatory reporting system is reinforced and information and alert messages are sent to health professionals. Exchanges are also continuing with other European countries, the WHO and the ECDC.