Cambodia: Confirmed two H5N1 avian flu cases, one died (11 yr. old female), the other case is her father, in Prey Veng Province - February 22, 2023+

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Updated on February 28, 2023


Date: 28-February-2023

So far in our country there are two cases of colds. The first case, an 11-year-old girl died, and the second case, the girl's father was healed and released from the hospital today.
According to the results of the investigation, both of them were infected with birds in the village, but there was no infection between father and son.

http://www.cdcmoh.gov.kh/793-2023-02-28-04-10-42

[Toaster2]

Another link to the statement. The wording here is a bit different

[sharon sanders]

Louise Moncla
@LouiseHMoncla
Thanks to incredible response and sequencing by
@E_A_Karlsson

@jurreysi
at IPC, the avian flu builds on
@nextstrain
hosted at https://nextstrain.org/flu/avian/h5nx have been updated with the recent human sequence from Cambodia.
11:57 AM · Feb 27, 2023
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Louise Moncla
@LouiseHMoncla
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Feb 27
Replying to
@LouiseHMoncla
As recapped by Erik's previous thread, https://twitter.com/E_A_Karlsson/status/1629711660398305280…, this human sequence is clade 2.3.2.1c, distinct from the clade 2.3.4.4 viruses causing the outbreaks in Europe and North America. This human sequence clusters most closely with other viruses sampled in Southeast Asia

Quote Tweet

Erik Karlsson
@E_A_Karlsson
·
Feb 26
Happy to announce that the full genome sequence of the Cambodian #H5N1 #avianflu case is now available on @GISAID. This has been an incredible effort by a number of people: (1/)
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Louise Moncla
@LouiseHMoncla
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Feb 27
Interestingly, H5 sequences sampled from Cambodia show a lot of diversity. Since 2020, H5N6, H5N8, and H5N1 have all been detected. The human case (red circle) descends from H5 strains that are endemic to Cambodia (blue tips), and are distinct from clade 2.3.4.4 (blue circle)

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Louise Moncla
@LouiseHMoncla
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Feb 27
This matches with what Erick and WHO reported: this human case was likely caused by endemic H5 lineages that have circulated in Cambodia for years rather than from the clade 2.3.4.4 viruses that have been in the news for causing mammal infections lately.
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Louise Moncla
@LouiseHMoncla
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Feb 27
This update also includes sequences from the recent outbreaks in pelicans in Chile. These sequences clearly branch from the diversity of the North American outbreak, showing H5 spread across the Americas. Thanks to the submitting authors for generating these data.

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Louise Moncla
@LouiseHMoncla
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Feb 27
Finally, we have a few small updates on the avian builds! We've added a colorby option for domestic/wild status for sequences that are annotated as such in GISAID. Domestic/wild distinction gives us more data to think about transmission, so this is great to see
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Louise Moncla
@LouiseHMoncla
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Feb 27
this data becoming more common https://nextstrain.org/flu/avian/h5nx/ha?c=domestic_status…. Finally, we've added author and accession ids as information that is viewable on the live builds. Thanks as always to the data generators and the entire
@nextstrain
team

[sharon sanders]

Erik Karlsson
@E_A_Karlsson
I would like to clarify recent statements in the press regarding the ##H5N1 virus detected recently in #Cambodia that were taken out of context. The confusion surrounds the implication that the virus has already gone “through” humans, and may be misinterpreted. (A thread - 1/)
12:22 AM · Mar 2, 2023
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Erik Karlsson
@E_A_Karlsson
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3h
Replying to
@E_A_Karlsson
For clarification, #H5N1 virus sequenced from the case in Cambodia shows certain changes that are anticipated and have been found in previous avian and/or human strains when they go from a bird to a human. (2/)
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Erik Karlsson
@E_A_Karlsson
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3h
This does *NOT* indicate that the virus is mutating or adapting to become human-to-human transmissible, nor does it state that the virus has already transmitted between humans. (3/)
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Erik Karlsson
@E_A_Karlsson
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3h
The Cambodian #H5N1 sequence, available on
@GISAID
, indicates presence of natural changes previously found in both avian viruses and/or other isolated human cases. The virus does *NOT* have the PB2627 or HZ225 mutations experimentally associated with mammalian transmission. (4/)
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Erik Karlsson
@E_A_Karlsson
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3h
The small adaptations we observe have been detected in spillover events into humans in the past, and have not resulted in sustained human-to-human transmission. **Rigorous experimental analysis is necessary to evaluate the effect of these mutations on this specific virus.** (5/)
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Erik Karlsson
@E_A_Karlsson
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3h
#AvianFlu is of the utmost concern. However, any implication that this #H5N1 virus is fully human adapted or transmissible between humans can lead to unwarranted fear. It is important that we continue to go with scientific, accurate and balanced information. (6/)
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Erik Karlsson
@E_A_Karlsson
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3h
@PasteurCambodia
continues to work with Cambodian and international authorities surrounding this case, and no implications of human-to-human transmission have been found. (7/)
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បច្ចុប្បន្នភាពថ្ងៃទី២ ខែមីនា ឆ្នាំ២០២៣


Updated: 02-Mar-2023

• មកទល់ពេលនេះ ករណីឆ្លងជំងឺគ្រុនផ្តាសាយបក្សី (A/H5N1) ចំនួនពីរករណីត្រូវបានរកឃេីញនៅក្នុងប្រទេសកម្ពុជា ។ គ្មានករណីបន្ថែមទៀតត្រូវបានរកឃើញទេ ។
• ករណីទីពីរត្រូវបានព្យាបាលនៅមន្ទីរពេទ្យ និងជាសះស្បេីយចេញពីមន្ទីរពេទ្យនៅថ្ងៃទី២៨ ខែកុម្ភៈ ឆ្នាំ២០២៣ បន្ទាប់ពីលទ្ធផលអវិជ្ជមានទីបីរបស់គាត់ ។
• រហូតមកដល់ពេលនេះ មិនទាន់រកឃេីញភស្តុតាងនៃការឆ្លងពីមនុស្សទៅមនុស្សទេ ។ ផ្អែកលើការស៊ើបអង្កេត ករណីទាំងពីរមានការប៉ះពាល់ជាមួយសត្វបក្សីឈឺ និងងាប់ដូចគ្នា ហើយរោគសញ្ញារបស់ពួកគេបានចាប់ផ្តើមនៅថ្ងៃតែមួយ ។
• ការវិភាគតាម Genome Sequencing និង phylogenetic ពីករណីទាំងពីរបានបង្ហាញថា មេរោគនេះគឺ clade 2.3.2.1c ស្រដៀងទៅនឹងមេរោគដែលកំពុងចរាចរនៅក្នុងបក្សីក្នុងស្រុ ក និងបក្សីព្រៃក្នុងប្រទេសកម្ពុជាចាប់តាំងពីឆ្នាំ២០១៣ មក ។
ព័ត៌មានបន្ថែមសូមទាក់ទងលេខ ១១៥

An update for 02 March 2023:
• To date, two cases of avian influenza virus (A/H5N1) have been confirmed in Cambodia. No further cases have been detected.
• The second case was treated in hospital and was discharged on 28 Feb 2023 following his third negative result.
• Thus far, there is no evidence of human-to-human transmission. Based on the investigations, both cases had exposure to sick and dead poultry and their symptoms started on the same day suggesting a common exposure.
• Genome sequencing and phylogenetic analysis from both cases revealed that the virus is clade 2.3.2.1c, similar to viruses circulating in domestic poultry and wild bird populations in Cambodia since 2013.

http://www.cdcmoh.gov.kh/794-2023-03-02-13-11-27

[Toaster2]

The sequence of the virus infecting the father is available now as well:

https://twitter.com/E_A_Karlsson/status/1631488209824907264?t=eZBy4xnmyVqTQcYkZQJTsw&s=19

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Health Ministry Spokesman Dismisses Rumors That H5N1 Bird Flu Case In Cambodia Is Human-To-Human Transmission

Release DateMarch 02, 2023

AKP Phnom Penh, March 03, 2023 -

On the night of March 2, 2023, Her Excellency Dr. O Vandin, Secretary of State and Spokesperson of the Ministry of Health of the Kingdom of Cambodia, announced the complete rejection of the release of false and inaccurate information both domestically and abroad on the case. The H5N1 bird flu virus, which was recently detected in Prey Veng province, is a case of human-to-human transmission.

She added that as of March 2, 2023, the Ministry of Health had found only two cases of H5N1 bird flu in Roleang village, Romlech commune, Sithor Kandal district, Prey Veng province. An 11-year-old girl died and her father recovered and was released from the district hospital.

The two positive cases of the H5N1 bird flu virus were concluded to be "transmission of the H5N1 bird flu virus from birds to humans, not from humans to humans," she said. Accurate or false and fabricated information spread by the media related to this case.

A total of 51 samples (from 20 closely related individuals and 31 individuals with flu-like symptoms) were collected for analysis, and all results were negative for the H5N1 virus. The Ministry of Health's research team is still present in Prey Veng province to investigate further cases of H5N1 bird flu and will continue to collect samples for analysis of suspected and influenza-like individuals. Well.

In addition, the Department of Virology at the Institut Pasteur du Cambodge confirmed the presence of the A / H5N1 virus in the samples sent for analysis and performed a detailed analysis of the full genome sequencing on GISAID (GISAID: Enabling rapid and open access to epidemic and pandemic virus data) on February 26, 2023. The A / H5N1 virus found in a case in Cambodia shows mutations that are expected to be transmitted from birds to humans, but this does not indicate that the virus is mutating or adapting to human transmission. To the people. The A / H5N1 virus in Cambodia does not have a mutation associated with an increase in mammalian transmission.

The Ministry of Health of Cambodia urges all media outlets to correct and take responsibility for the information they publish and ensure that their reporting is based on accurate scientific evidence and accurate quotes. For more information, please contact the Ministry of Health Hotline 115 for free. By Phen Rattanak, Posted by: Kan Chamnan
https://www.information.gov.kh/articles/98857

[Shiloh]

Source: https://www.khmertimeskh.com/5012494...u-in-cambodia/

Centers for Disease Control provides update on H5N1 Bird Flu in Cambodia
19 mins ago - BREAKING NEWS

The Centers for Disease Control and Prevention and National Center for Immunization and Respiratory Diseases have provided updated results of a preliminary assessment of the H5N1 viruses identified in two human infections detected in Cambodia in 2023 based on their genetic sequences and gives an update on the epidemiological investigation.

On February 26, 2023, the Institut Pasteur du Cambodge, in collaboration with the Cambodian Ministry of Health, shared the full genetic sequence of the H5N1 virus recovered from the patient who died in that country on February 22, 2023.

The genetic sequence of the second case was later also shared by the Institut Pasteur du Cambodge. CDC has conducted a preliminary analysis of the genetic sequences of these H5N1 bird flu viruses.

They are H5N1 viruses from clade 2.3.2.1c, which are different from the H5N1 viruses now spreading in U.S. wild birds and poultry, which are from clade 2.3.4.4b. These viruses are similar to past 2.3.2.1c viruses detected in that geographic area over recent years...

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Cambodia - 1 new outbreak of highly pathogenic avian influenza H5N1 in wildlife in Torb Sdarch village, Prey Veng province (WOAH, March 6, 2023)

https://flutrackers.com/forum/forum/cambodia/cambodia-h5n1-tracking/969916-cambodia-1-new-outbreak-of-highly-pathogenic-avian-influenza-h5n1-in-wildlife-in-torb-sdarch-village-prey-veng-province-woah-march-6-2023

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Translation Google


Bird flu kills smart girl from Rolling community

March 13, 2023
Hul Reaksmey

For generations, people have lived in Roleang village in Prey Veng province, more than 60 kilometers from the Prek Ta Mak bridge in Khsach Kandal district, Kandal province. Never before has there been a case of bird flu that health experts call H5N1. But in late February, an outbreak broke out in the village, which is rich in farmers, and caused the girls to die. A smart young man lost his life in a short time.

With a sad face, Kin Narin, the mother of 11-year-old Bien Narong, who died of the flu The bird described her daughter's death as "too early and almost unbelievable".

She added that her daughter was a child who loved and cared about her studies. Bien Narong, a sixth-grade student at Hun Sen Primary School, died before bird flu claimed her life.

The 47-year-old woman, who has been working as a cashew picker in Stung Treng province for the past two years, said: VOA's daughter says before she fell seriously ill with bird flu that Bian Narong refused to go to the hospital No, because she was worried that she would miss the exam like other students.

"Go to the doctor, do not want to go, it cries, do not want to go [anyone] can hear, cry, do not cry," she said. No, I'm still in the exam. I went to the doctor and he wanted to go to this exam, he was afraid the teacher would not let him go to the exam, so he did not enter the class. Seventh. I said, child, the teacher understands too much when you are sick, so they do not mind, you go to the exam, go to the doctor first, remember When your child comes back to the exam, he refuses to cry. ”

Ms. Kin Narin described that just a few days later, she took medicine at home and was treated at a referral hospital in Prek Sandek village in Sithor district. In the middle of her daughter's condition, she was still not feeling well and was later sent by the medical staff to the National Children's Hospital in Phnom Penh, where the girl He died on February 22.

She confirmed that she did not know in advance the symptoms of bird flu infection. However, she said that her daughter was hot and cold and was taken to a hospital in Prek Sandek Ti village, where doctors said the symptoms were not serious. Seriously.

She said: "If you know that your child is sick, you also rush to call people to help you when you do not know, just Hot, it is not normal hot, I used to say that my child has a fever, not ever, fever, cold, buy medicine to buy Well, it's fine, this message to inject serum and my child does not recover.

According to a statement issued by the Minister of Health on February 23, a girl in Roleang village who was diagnosed with bird flu became ill on February 16, 2023 with symptoms of fever (39 ° C) as well as cough and sore throat after receiving treatment in Min village After 3 days of relief, the girl began to feel tired and was sent to the National Children's Hospital in Phnom Penh on February 21, 2023

In Roleang village, Kin Narin and her husband, 49-year-old Bien Vorn, are farmers and have four children. The youngest girl. Their house is near the lake, which receives water from the Mekong River.

Under the old Khmer house built by Kin Narin, there is an unorganized chicken farm. One.

She said her family raised chickens as a family and many chickens were collected for sale during the Chinese New Year. There are only two hens left. She said officials took the two hens to test for the virus after her daughter was presumed infected. Her family has been raising chickens for many years to eat at home and sell at the market. To support the family.

She said that before her daughter became infected and died of bird flu, her children did not touch the chickens. Who feeds in the house.

"He never plays with chickens, he knows how to wash dishes, he knows how to cook, he knows how to wash his own clothes, he knows how to cook," she said. Go to the pagoda, okay? ”

Roleang village is located in Romlech commune, Sithor Kandal district, Prey Veng province, bordering Vietnam to the south. This quiet village has more than 370 families, equivalent to more than 1,900 people, most of whom are engaged in business. Depends on agriculture. This is according to the officials at the commune hall and the people who were interviewed by VOA Khmer.

The case of Bean Narong flu infection is the first case after this disease, there are no new cases in Cambodia during Nine years ago.

Following the discovery of the case, public health experts found that the girl's father was also infected with the H5N1 bird flu. Health experts confirmed that he contracted the disease on February 23. His daughter died of H5N1 bird flu on Feb. 22, a day after she was diagnosed with the H5N1 virus. There are serious effects on the respiratory tract, according to the World Health Organization.

Bien Vorn was treated at the District Referral Hospital after he was diagnosed with bird flu and left the hospital. Doctors on February 28 after his third negative result. This is according to the people in Roleang village and the announcement of the Department of Combating Infectious Diseases.

However, in Roleang village on 28 February, Prey Veng provincial health workers continued to take samples of students in the village. Then take the test. Health workers present in the village said that continuing to monitor the bird flu situation in the village will Use for 14 days.

A statement from the Department of Communicable Diseases on March 2, posted on Facebook, explained that there were no cases of H5N1 infection. More to be found. And so far no evidence of human-to-human transmission has been found. The statement said that based on the investigation of the two cases found in Roleang village, there was a conflict with Birds get sick and die the same way, and their symptoms start the same day.

In a separate statement, the Department of Infectious Diseases said that the H5N1 bird flu virus had erupted in Roleang village, Romlech commune. Sithor Kandal is a virus that has been studied among domestic and wild birds in Cambodia during recent years. The H5N1 bird flu virus, dubbed (clade 2.3.2.1c), differs from the H5N1 bird flu virus in other parts of the world. This is according to the Department of Infectious Diseases of the Ministry of Health of Cambodia.

Human-to-human transmission of bird flu was first reported in Cambodia in 2014. According to the World Health Organization, based on the available evidence so far, bird flu virus is not easily transmitted to humans. No, and that person-to-person transmission is not uncommon.

However, the World Health Organization warns that because the virus continues to be found in birds, the virus could spread from person to person. Animals on humans can be expected to continue to occur.

According to the Ministry of Health, there are no new cases in this village. The Ministry also confirmed

Similarly, Ket Hum, another villager in Rolaing village, told VOA Khmer that she had never received any news or coverage from Local authorities say there are no symptoms of bird flu. A neighbor of Bien Narong's family, she was shocked when the friendly girl died. The bird flu.

"I can only see the ugly face, to be honest, the innocent child is very good," she said. One of them is the most beautiful, the most beautiful. I'm eating, at 6 or 7 o'clock, it comes from school, come and ask me every day, my tears just in time Eat, I remember. My house is still on the road, it came to my house, ”he said.

Kin Narin, 65, the sister of Bien Narong, still remembers her niece as a hard worker and Have a dream to be a doctor.

"I grew up wanting to be a doctor, I wanted to be a doctor ... I tried to study," she told VOA.

Having taken care of the girl since she was a child, Kin Narin expressed her grief over her niece's death.

She said: "Nowadays, sleeping next to a photo, lying next to it, looking and crying, looking sad. "Very nephew."

For Kin Narin, she has not been able to forget her daughter. And what she still remembers about her child is her ability to communicate with Bien Narong's parents when she was alive.

https://khmer.voanews.com/a/family-remembers-the-life-of-a-bright-girl-before-h5n1-took-her-life-away/7001920.html