[Source: Antimicrobial Agents and Chemotherapy, full page: (LINK). Abstract, edited.]

Carbapenemase-producing Enterobacteriaceae in Spain (2012)

Jes?s Oteo 1*, David Saez 1, Ver?nica Bautista 1, Sara Fern?ndez-Romero 1, Juan Manuel Hern?ndez-Molina 2, Mar?a P?rez-V?zquez 1, Bel?n Aracil 1, Jos? Campos 1,3, the Spanish collaborating Group for the Antibiotic Resistance Surveillance Program

Author Affiliations: <SUP>1</SUP>Antibiotic laboratory, Bacteriology Department, Centro Nacional de Microbiolog?a, Majadahonda, Madrid, Spain. <SUP>2</SUP>Microbiology Department, Hospital Universitario Carlos Haya, M?laga, Spain. <SUP>3</SUP>Consejo Superior de Investigaciones Cient?ficas, Madrid, Spain.


We report the epidemiological impact of carbapenemases-producing Enterobacteriaceae (CPE) in Spain in 2012. Of the 237 carbapenemases detected 163 were OXA-48 group, 60 VIM-1, 8 KPC-2, 5 IMP group, and one NDM-1. Inter-hospital spread of carbapenemase-producing K. pneumoniae was due to a limited number of MLST and carbapenemases types including ST15/VIM-1, ST11/OXA-48, ST405/OXA-48, ST101/KPC-2 and ST11/VIM-1. The number of CPE in Spain has increased sharply in recent years mainly due to the emergence of OXA-48.


* Corresponding author. Centro Nacional de Microbiolog?a, Instituto de Salud Carlos III, Carretera Pozuelo a Majadahonda, 28220 Majadahonda, Madrid, Spain. Tel: +34?918223650; Fax: +34-915097966; E-mail: jesus.oteo@isciii.es

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