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Another important clinical issue is whether SSRIs are continued or discontinued when a COVID-19 patient is hospitalized or admitted to an ICU. SSRIs are frequently discontinued in the ICU patient [42,43]. There is literature showing that discontinuation results in adverse ICU outcomes [42,43]. SSRIs are often inadvertently discontinued because they are not considered important in acute disease. This can cause increased agitation among these patients and need for additional sedation, which may in turn depress respiration.