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Discussion: Chinese Academy of Sciences (CAS) in Wuhan has been working with bats and coronavirus for many years - DNA manipulations, cloning.... - Ja


Peter Daszak: 'Colleagues in China' Sequencing Coronavirus Spike Proteins

Jun 9, 2021

Peter Daszak, President of EcoHealth Alliance, describes how his colleagues in China sequence Coronavirus spike proteins in order to anticipate the next Pandemic.

"We've just got to do it. I just makes sense economically and for humanity's sake"

Air Date: February 23rd, 2016


------------------------------------------------------------------------------------------

The video above is an excerpt from this conference:

FEBRUARY 23, 2016
Pandemics


Sonia Shah moderated a forum on emerging infectious diseases and the next pandemic. The event began with Ms. Shah discussing her book, Pandemic: Tracking Contagions, From Cholera to Ebola and Beyond.

https://www.c-span.org/video/?404875-1/pandemics


01:16
Peter Daszak

...
"Some of the viruses will be killers, and some of them won't. How do we work that out from a viral sequence? It is not straightforward. As an example, first of all, we are only looking at viral families that include those that have gotten to people from animals. So we narrow it down straight away. Then when you get a sequence of a virus, and it looks like a relative of a known nasty pathogen, just like we did with SARS. We found other coronaviruses in bats, a whole host of them, some of them looked very similar to SARS. So we sequenced the spike protein, the protein that attaches to cells. Then we… Well I didn’t do this work, but my colleagues in China did the work. You create pseudo particles, you insert the spike proteins from those viruses, see if they bind to human cells. At each step of this, you move closer and closer to this virus could really become pathogenic in people. So you narrow down the field, you reduce the cost, and you end up with a small number of viruses that really do look like killers. And then you look in people, and you say in the people that live in the region where this animal lives, that are exposed to that virus, do we see antibodies specific to that virus?..."
 
What the World Wants China to Disclose in Wuhan Lab Leak Probe

By Kwan Wei Kevin Tan and Jason Gale
June 11, 2021, 1:27 AM CST
...
Here’s what a new study should examine:

One big outstanding question is what type of work was actually going on in the Wuhan Institute of Virology. Shi Zhengli, the top bat coronavirus researcher at the lab, said in a March 2020 article in Scientific American that the genetic code of the virus that causes Covid-19 doesn’t match any of her lab’s samples. She also told the WHO team that all staff had tested negative for Covid-19 antibodies.

Still, researchers haven’t yet had access to all coronavirus isolates and genomic sequence data held at Wuhan labs. And they also haven’t had access to log books and records of the research that was being conducted on coronaviruses, in particular viruses with the RaTG13 bat sequence that is similar to SARS-CoV-2, the pathogen underpinning Covid-19.

There are also questions about whether the institute conducted gain-of-function experiments, in which researchers manipulate naturally occurring viruses to see if they can be made deadlier or more transmissible.
...
https://www.bloomberg.com/news/arti...nts-china-to-disclose-in-wuhan-lab-leak-probe
 
Translation Google

UNITED STATES

Brinken asked Yang Jiechi to investigate the source of the virus: China still has a way if China does not cooperate

June 12, 2021 04:46
Lin Fengt

WASHINGTON—

The United States has formally proposed to Beijing to conduct the second phase of the traceability investigation of the new coronavirus in China. When U.S. Secretary of State Blincoln had a phone call with Yang Jiechi, a member of the Political Bureau of the CPC Central Committee in charge of foreign affairs, on June 11, he asked China to strengthen cooperation and transparency on the issue of the traceability of the new crown virus, including the expert-led World Health Organization (WHO) in China. ) The second stage virus traceability investigation. Experts said that even if China does not cooperate, the United States has a way to initiate related investigations.
...
Richard Ebright, a molecular biologist at Rutgers University, was one of the first scientists to propose that the new coronavirus may come from a laboratory leak or accident. He and some other internationally renowned scientists signed an open letter to the WHO in March this year, arguing that there were flaws in the WHO-China joint virus traceability investigation and did not solve the hypothesis that the virus came from laboratory escape.

In an interview with Voice of America, Ebright said that the scientific community is currently divided on whether the virus came from nature or escaped from the laboratory because the current evidence does not deny the theory of laboratory leakage.

He said: "There is no scientific evidence that allows us to choose between the two possibilities of natural spillover origin and laboratory spillover origin. All scientific evidence and all other safety evidences are equally in line with these two possibilities. . There has never been a scientific consensus to the contrary."
...
Ebright said that investigating whether the new coronavirus originated in a laboratory is beyond the scope of science, and that the investigation of the virus laboratory's leak theory should be completed by forensic investigation.

He said: "The answer to this question will come from traditional investigations, forensic investigations, and there is room for investigation in China. But this kind of investigation will require the cooperation of the Chinese government and the Wuhan Institute of Virology. This form of investigation It will take the form of inspections, checking laboratory facilities, checking laboratory notebooks, checking electronic databases, checking freezer samples, extracting samples from the freezer and performing sequencing, interviewing staff, from ground managers and maintenance personnel to security personnel, to All personnel, including laboratory staff and management personnel, should interview them one by one in private without government supervision. This will require access to the medical records of these personnel and the serological samples of these personnel."

But so far, Beijing has been tough. In a call with Secretary of State Brinken, Yang Jiechi, director of the Office of the Foreign Affairs Commission of the CPC Central Committee, accused the leak of the new crown virus from the Wuhan laboratory as a "ridiculous story" fabricated by some people in the United States. He said that China expresses serious concern about this and urges the US not to politicize the traceability issue and to focus on international cooperation in fighting the epidemic.

The World Health Organization also recently stated that they cannot force China to provide more information on the source of the new coronavirus. Michael Ryan, the executive director of the organization's emergency project, was asked on June 7 how the WHO forced China to be more open and said, "The WHO has no power to force anyone in this regard."
...
But Ebright believes that even without China’s cooperation, the United States is still capable of launching relevant investigations within the United States.

He said: "The key point here is that all the work done by the Wuhan Institute of Virology on bat SARS-related coronaviruses is carried out through contract cooperation with an NGO. This NGO is located in New York City and is named ' EcoHealth Alliance' (EcoHealth Alliance), therefore, the'EcoHealth Alliance' will have electronic and paper documents in its hard disk and file cabinets. These documents may provide very important and useful information for solving the origin problem, and they will apply for it. Funding proposals, grant progress reports, raw data from the Wuhan laboratory, analysis data from the Wuhan laboratory, draft scientific papers written with the Wuhan laboratory, and extensive correspondence with the Wuhan laboratory. These are the American public and American policies. The information that the makers need to obtain because we pay for it. We provided $123 million, which was provided by the federal government to the Eco-Health Alliance for this and other projects."
...
Peter Daszak, president of the "Ecological Health Alliance", is the only expert from the United States in the expert team sent by the WHO to China to investigate the source of the virus. According to a report from Vanity Fair, the three candidate panel members nominated by the U.S. government—a U.S. FDA veterinarian, a U.S. Centers for Disease Control (CDC) epidemiologist, and U.S. National Institute of Allergy and Infectious Diseases (NIAID) None of the virologists were selected.

Ebright said that the U.S. Congress or the Department of Justice should promptly initiate an investigation and summon relevant personnel. Matthew Pottinger, who served as the US Deputy National Security Adviser in the Trump Administration, also said earlier that the US Congress should establish a cross-party investigative committee to investigate the theory that the new crown virus originated from laboratory escape.

Boming testified at a hearing held by the U.S. Senate Armed Services Committee on June 8: “I think a bipartisan committee with subpoena power should be established quickly. I think we need to stop the (virus) gain-of function. -function) research, and take the lead on a global scale, and restore Obama’s ban on functional gain research. The ban is intended to help predict the current pandemic, but it may actually plant the seeds for this pandemic. "

Those who support the theory that the new coronavirus comes from laboratory leakage believe that the functional gain study of viruses can increase the pathogenicity and infectivity of pathogens by cross-mixing different types of viruses. It has a high risk and may cause viruses. leakage.

China's rebuttal

Chinese state media "Global Times" published a report on the English website on June 9 that Yuan Zhiming, director of the Wuhan National Biosafety Laboratory of the Wuhan Institute of Virology, stated that they kept serum samples for laboratory staff every year and did not receive any For reports of abnormal diseases, all staff tested negative for antibodies to the new coronavirus. Regarding the positive influenza cases from October to November 2019, he said that this was a retrospective study conducted by the institute in cooperation with Wuhan Union Medical College Hospital. A total of 1,001 samples were collected from hospital patients. There were no samples in December 2019. Positive samples were found, and four cases of influenza and new coronavirus mixed infections were found in 700 samples in January 2020. The report said that these four cases of mixed infection were not laboratory staff of the Wuhan Institute of Virology.

This seems to be a response to the three researchers from Wuhan Institute of Virology that the Wall Street Journal reported exclusively in May based on an intelligence report from the U.S. Department of State, who went to the hospital for treatment after developing serious illness in November 2019. That report led to the theory that the virus leaked from the laboratory to a certain extent, once again attracted public attention.

Ebright told VOA that this statement was inconsistent with and contradicted the information provided by the Chinese government to the WHO traceability investigation expert group, and it was also inconsistent with the information obtained by the Australian and US governments.

The spokesperson of the Chinese Ministry of Foreign Affairs Wang Wenbin once again called the leak of the new crown virus from a laboratory a "rumor" and said that the United States should open the Ft. Detrick biological base in Maryland for the WHO to carry out. Virus traceability investigation.

Ebright said that this is the Chinese government's diversion of attention from the source of the virus. He said: "A key issue to remember here is that genetic evolution analysis, that is, the family tree of virus sequences, shows that the virus came from Wuhan, clearly showing that it came from Hubei Province, between September and November 2009 ( Originated from) Wuhan or nearby, so the time and place of the virus appearing are known. There is no ambiguity. (China) said that the virus appeared in Fort Detrick or near Fort Detrick , There is no possibility, it is zero!"


https://www.voachinese.com/a/us-coronavirus-origins-investigation-20210611/5925697.html
 
Australian professor says 'lot of different routes' possible for Covid-19 lab leak theory

6 MIN AGO • SOURCE: 1 NEWS
...
Nikolai Petrovsky, a Professor of Medicine at Adelaide’s Flinders University, told Q+A he believes the theory that the virus was leaked from a laboratory has merit.
...
"We've put forward a number of different scenarios by which this could happen," he said.

"It ranges from the idea that a researcher who's collecting samples from, say, bat caves may have themselves got infected in the process of the collection and then travelled back to the lab in Wuhan not knowing they were infected.

"They could innocently have gone back to the lab and then started the outbreak by infecting someone else in the lab or their family."
...
"We also know they weren't just collecting these viruses in the bat caves but also culturing them in the labs and when you do that, you're adapting the virus and that can make the virus much more prone to infecting humans.

"And then accidentally you touch a plate, and you touch your mouth - that's all it takes to infect yourself. It wouldn't be the first time."

He added the infection didn't have to take place at the lab itself too for the theory to work.

"They [could not] dispose of the waste properly from the laboratory appropriately so they don't inactivate the waste, it goes to a rubbish dump, it gets picked up by an animal and they infect a human or a human in the rubbish collection or processing picks it up from the waste.
...

https://www.tvnz.co.nz/one-news/wor...rent-routes-possible-covid-19-lab-leak-theory
 
G7 summit: World leaders discuss COVID origins - as WHO keeps Wuhan lab leak theory 'open'
...
By Greg Heffer, political reporter, in Cornwall
Saturday 12 June 2021 20:39, UK
...
At their summit in Cornwall on Saturday, G7 leaders were joined by Dr Tedros Adhanom Ghebreyesus, the WHO's director general, during their talks on the COVID crisis and efforts to avoid future pandemics.
...
Referring to the millions around the world who have died due to COVID, Dr Tedros said: "This is very tragic and I think the respect these people deserve is knowing what the origin of this virus is, so we can prevent it from happening again."

Dr Tedros confirmed the WHO was preparing for the second phase of its investigation into the origins of COVID, which he said would need "transparency" and the "cooperation" of China.

"We believe that all hypotheses should be open and we need to proceed with the second phase to really know the origins," he said.
...
https://news.sky.com/story/g7-summi...who-keeps-wuhan-lab-leak-theory-open-12331212
 
https://www.researchgate.net/public..._provide_insights_into_controlling_the_COVID-
19_pandemic_Serpentinization-induced_lithospheric_long-wavelength_magnetic_anomalies_in_Proterozoic_bedrocks_in_a_weakened_
Figure 4: SARS-CoV-2-like Nucleocapsid antigen in COVID-19-like diseased laboratory rats in the absence of experimental induction. (A)Immunohistochemistry analysis of SARS-CoV-1/2 nucleocapsid (brown) in healthy (column 1) and COVID-19-like diseased rats (n=3, from November 2019, column 3) demonstrate the presence of the SARS-CoV-1/2 Nucleocapsid antigen in the lung epithelial cells and renaltubular epithelial cells in COVID-19-like diseased rats (black arrow). (B) Immunohistochemistry staining of the lung from COVID-19-like diseased rat (from November 2019, column 1-2) with the detection system (secondary antibody and the chromogen detector) in the absence (column 1, Minus Anti-NP) or presence (column 2, Plus Anti-NP) of anti-SARS-CoV-1/2 nucleocapsid primary antibody (brown) demostrates the specificity of the staining procedure. The staining of the lung from a healthy rat (column 3) with anti-SARS-CoV-1/2 nucleocapsid primary antibody and the detection system (secondary antibody and the chromogen detector) confirms the specificity of the staining procedure. (C)Immunohistochemistry analysis of SARS-CoV-1/2 nucleocapsid (brown) in COVID-19-like diseased rats (n=5, from March-July 2020) demonstrate the presence of the SARS-CoV-1/2 Nucleocapsid antigen in the lung epithelial cells and renaltubular epithelial cells in COVID-19-like diseased rats (black arrow). Note: Molecular diagnostics for SARS-CoV-2 antigen was not perform on all animals with the COVID-19-like disease. The specificity of the anti-SARS-CoV-1/2 nucleocapsid primary antibody was validated by Alejandro Best Rocha et al, 2020 in human samples.

Bility, Moses. (2020). Can Traditional Chinese Medicine provide insights into controlling the COVID-19 pandemic: Serpentinization-induced lithospheric long-wavelength magnetic anomalies in Proterozoic bedrocks in a weakened geomagnetic field mediate the aberrant transformation of biogenic molecules in COVID-19 via magnetic catalysis. 10.13140/RG.2.2.30887.09128.


Did a SARS2-like virus infect a rat colony as far back as 11-2019 at the University of Pittsburgh? Was BSL-3 containment breached and a pathogen got into an unrelated area where these rats were housed?

https://www.cvr.pitt.edu/facilities/regional-biocontainment-laboratory/capabilities
Aerobiology

Aerobiology facilitates aerosol exposures of animal models to BSL-3 pathogens. The University of Pittsburgh RBL has a dedicated U.S. Army Medical Research Institute of Infectious Diseases(USAMRIID)-trained aerobiologist as well as a dedicated staff for conducting aerosol exposures.

The aerobiology suite has a class III biosafety cabinet (glove box) and uses a mobile transfer cart system for transportation of animals to and from the aerobiology suite. Aerosol exposures are generated using a Collison 3-jet nebulizer controlled by the AeroMP automated aerosol control system from Biaera Technologies.
 
Video

WORLD EXCLUSIVE: Footage proves bats were kept in Wuhan lab

Sharri Markson |13/06/2021|17min

The Wuhan Institute of Virology kept live bats in cages, new footage from inside the facility has revealed, disproving denials from World Health Organisation investigators who claimed the suggestion was a “conspiracy”.
...
The World Health Organisation report investigating the origin of the pandemic failed to mention that any bats had been kept at the Wuhan Institute of Virology and only its annex referred to animals being housed there.
...
A member of the World Health Organisation team investigating the origin of the pandemic in Wuhan, zoologist Peter Daszak said it was a conspiracy to suggest bats were held at the Wuhan Institute of Virology.

In one tweet dated December, 2020 he said: “No BATS were sent to Wuhan lab for genetic analysis of viruses collected in the field. That’s now how this science works. We collect bat samples, send them to the lab. We RELEASE bats where we catch them!”

In another tweet, dated December 11, 2020, he said: “This is a widely circulated conspiracy theory. This piece describes work I’m the lead on and labs I’ve collaborated with for 15 years. They DO NOT have live or dead bats in them. There is no evidence anywhere that this happened. It’s an error I hope will be corrected.”

This month, Daszak appeared to retract his earlier denials and admitted the Wuhan Institute of Virology may have housed bats but admitted he had not asked them.
...
https://www.skynews.com.au/details/_6258639874001
 
When he thought no bats were being housed and killed at the Wuhan lab, he said those activities would be dangerous. Will he try to now claim it is not dangerous?

https://www.dailymail.co.uk/news/ar...-planned-breed-animals-virus-experiments.html
"Responding to a question over whether researchers were keeping live bats, Mr Daszak tweeted in April last year: 'The researchers don't keep the bats, nor do they kill them.

'All bats are released back to their cave site after sampling. It's a conservation measure and is much safer in terms of disease spread than killing them or trying to keep them in a lab.'"
 
Chinese Lab-Leak Investigators Demand Inquiry into Role Science Journals Played During Pandemic

By Jamie Dettmer
June 14, 2021 08:15 AM

Scientists who have been challenging the theory that the coronavirus emerged naturally and couldn’t have leaked from a Chinese lab are calling for an inquiry into the role played during the pandemic by leading Western science and medical journals, including Nature and The Lancet.

They say the editors of the influential journals rebuffed dozens of critical articles which raised at least the possibility of the coronavirus being engineered and that it might have subsequently leaked from a lab in Chinese city of Wuhan. 

“The managers of these journals may have wanted to appease the Chinese Communist Party, as China is where an increasing proportion of their revenue comes from, and China has made it clear that those journals it supports must agree to adhere to its policy agendas,” Nikolai Petrovsky, a professor of medicine at Australia’s Flinders University, told VOA.

“So many papers questioning the origins were quickly rejected by the journal editors at Nature and Lancet, etc. without even being sent for review. This early rejection was therefore presumably largely not on scientific grounds but on political or other grounds determined at a high level within those journals,” he says. 

The editors of The Lancet and Nature reject the complaints, saying scientific merit determines the submissions they pick to publish and not politics.

Petrovsky is one of dozens of scientists skeptical of the natural-spillover theory who say their efforts to point out inconsistencies in the quickly established standard narrative was met with silence, rejection and hostility by the editors of major Western science journals. 
...

Another, Richard Ebright, a professor of chemical biology at Rutgers University in New Jersey, says there should be a “day of reckoning.” In an email exchange with VOA he said: “Untruthful statements and improper actions by scientists and science journalists who established and enforced the false narrative extended far beyond refusing to consider papers challenging the false narrative.” 

Ebright and others allege some non-peer-reviewed were rushed into print, if they supported the conventional narrative. Those articles in turn set the tone for general media coverage, they add. “Starting in January 2020 and continuing through early 2021, a small group of scientists, and a larger group of science journalists, established and enforced the false narrative that scientific evidence supported natural spillover and a false narrative that this was the scientific consensus,” says Ebright. 
...

Full text:
https://www.voanews.com/covid-19-pa...d-inquiry-role-science-journals-played-during
 
Whether Covid escaped from a lab or not, it’s time to talk about biosecurity


The debate on the origins of the Covid-19 pandemic has recently focused on the potential for the Sars-CoV-2 virus to have escaped from the Wuhan Institute of Virology, located in the Chinese city of Wuhan, the centre of the pandemic. This institute houses a maximum containment laboratory, more commonly known as a biosafety level 4 (BSL-4) lab, designed to handle dangerous pathogens for which there are no available treatments or vaccines.

The controversy has brought renewed attention to biosafety, biosecurity, “gain-of-function” and other “dual-use” research, along with consideration of the level of oversight that such labs should be operating under. Although this debate has become polarised and politicised, we should not lose sight of the importance of these issues, even if it turns out this lab had nothing to do with the emergence of the novel coronavirus. Concerns about whether labs are conducting their research safely, securely and responsibly are not new, or of relevance solely to labs in China – as revealed by a comprehensive study on global BSL-4 labs that we recently completed.


..


https://www.theguardian.com/comment...d-escaped-lab-or-not-biosecurity-laboratories
 
Ex-CDC chief Robert Redfield explains belief COVID came from China lab

By Yaron SteinbuchJune 15, 2021 | 11:40am | Updated

Former CDC Director Robert Redfield defended the theory that COVID-19 escaped from a Chinese lab, arguing the deadly bug’s efficient human-to-human spread contradicted the behavior of other deadly coronaviruses with similar profiles — and was simply not “biologically plausible.”

“I said before that I didn’t think it was biologically plausible that COVID-19 went from a bat to some unknown animal into man and now had become one of the most infectious viruses,” Redfield said during an interview with Fox News.

“That’s not consistent with how other coronaviruses have come into the human species. And, it does suggest that there’s an alternative hypothesis that it went from a bat virus, got into a laboratory, where in the laboratory, it was taught, educated, it evolved, so that it became a virus that could efficiently transmit human to human,” he added.
...
He argued that COVID-19’s efficient human-to-human spread contradicted the behavior of other deadly bugs, such as SARS and MERS, which first infected people through animal contact but spread at a much slower pace, Fox News reported.
...
Redfield expressed disappointment in what he described as a “lack of openness” in the scientific community to “pursue both hypotheses.”

“I’m just giving my best opinion as a virologist, and I don’t think it’s plausible that this virus went from a bat to an animal — we still don’t know that animal — and then went into humans and immediately had learned how to be human-to-human transmissible to the point of now causing one of the greatest pandemics we’ve had in the history of the world,” Redfield told Fox News.
...
Redfield also voiced doubt about the integrity of the World Health Organization, which concluded in a joint report with China that a lab leak was “extremely unlikely.”

He argued the WHO was “too compromised” by Beijing’s influence to carry out a truly transparent probe.

Clearly, they were incapable of compelling China to adhere to the treaty agreements that they have on global health, because they didn’t do that. Clearly, they allowed China to define the group of scientists that could come and investigate,” Redfield told the news outlet. “That’s not consistent with their role.”
...
https://nypost.com/2021/06/15/ex-cdc-chief-explains-belief-covid-19-came-from-china-lab/
 
Outbreak-origin investigations often take years, and some culprits remain unknown. It took 14 years to nail down the origin of the SARS epidemic, which began with a virus in bats that spread to humans, most likely through civets. To date, a complete Ebola virus has never been isolated from an animal in the region where the world’s largest outbreak occurred between 2013 and 2016.

Origin investigations are complicated because outbreaks among animals that aren't the main hosts of a particular virus, such as civets in the case of SARS, are often sporadic. Researchers must find the right animal before it dies or clears the infection. And, even if the animal tests positive, viruses found in saliva, faeces or blood are often degraded, making it difficult to sequence the pathogen’s whole genome.

https://www.nature.com/articles/d41586-021-01529-3
 
OPINION COMMENTARY

Beijing Protests a Lab Leak Too Much

Strong evidence the virus escaped: the Communist Party’s vicious attacks on anyone who speaks out.

By Perry Link
Updated June 13, 2021 11:42 am ET

I am as eager as anyone to follow the world’s virologists as they try to determine how Covid-19 emerged in Wuhan, China. But as a longtime student of Chinese Communist political language, I will need considerable persuading that the disease came from bats or a wet market. The linguistic evidence is overwhelming that Chinese leaders believe the Wuhan Institute of Virology was the source.

Many years ago a distinguished Chinese writer, Wu Zuxiang, explained to me that there is truth in Communist Party pronouncements, butyou have to read them “upside down.”If a newspaper says “the Party has made great strides against corruption in Henan,” then you know that corruption has recently been especially bad in Henan. If you read about the heroic rescue of eight miners somewhere, you can guess that a mine collapse might have killed hundreds who aren’t mentioned. Read upside-down, there is a sense in which the official press never lies. It cannot lie. It has to tell you what the party wants you to believe, and if you can figure out the party’s motive—which always exists—then you have a sense of the truth.

A few years ago another outstanding Chinese writer, Su Xiaokang, brought me one step deeper. You Westerners, he explained, are too hung up on the question of whether propaganda is true or not. For the regime, truth and falsity are beside the point. A statement might be true, false or partly true. What matters is only whether it works. Does it advance the interests of the party?The top leaders hand out words and phrases for their minions to use, like trowels in a garden. The minions dig with them.
...

https://www.wsj.com/articles/beijing-protests-a-lab-leak-too-much-11623598397

---------------------------------------------------------------

Princeton University
Department of East Asian Studies

Perry Link
Professor Emeritus of East Asian Studies, specializes in 20th-century Chinese literature. He received his B.A. from Harvard in 1966 and his Ph.D. from Harvard in 1976...

https://eas.princeton.edu/people/perry-link
 
...Many years ago a distinguished Chinese writer, Wu Zuxiang, explained to me that there is truth in Communist Party pronouncements, but you have to read them “upside down.”If a newspaper says “the Party has made great strides against corruption in Henan,” then you know that corruption has recently been especially bad in Henan. If you read about the heroic rescue of eight miners somewhere, you can guess that a mine collapse might have killed hundreds who aren’t mentioned. Read upside-down,..

My experience since 2006. Exactly.
 
Did COVID-19 Leak From A Lab? A Reporter Investigates — And Finds Roadblocks
June 17, 20211:54 PM ET
42-Minute Listen

Transcript

TERRY GROSS, HOST:

This is FRESH AIR. I'm Terry Gross. In order to prevent another disaster pandemic, it would be helpful to know with greater certainty how this one started. Many of us assumed that was a settled issue. The virus jumped from an animal to a human, and it spread. The theory that the virus had escaped from a lab in Wuhan, China, seemed to have been dismissed as an explanation advocated by Trump and his allies to blame China for what Trump liked to call the China virus. But last month, President Biden announced he asked the intelligence community to redouble their efforts to examine whether COVID-19 emerged from human contact with an infected animal or from a laboratory accident. Answering that question is also one of the goals of the COVID Commission Planning Group, a nonpartisan group directed by Philip Zelikow, who also directed the 9/11 Commission.

This week, world leaders at the G-7 summit called for a new investigation into the origins of the virus. My guest, journalist Katherine Eban, has been leading her own investigation into the lab leak theory and whether it's credible. She says, when Trump floated the lab leak hypothesis last April, his divisiveness and lack of credibility made the lab leak theory largely off-limits. She reports that those who pushed for transparency say toxic politics and hidden agendas kept us in the dark. But now that Trump is out of office, she says it should be possible to reject his xenophobic agenda and still ask, why did the outbreak begin in the city with a lab housing one of the world's most extensive collections of bad viruses and doing some of the most aggressive research?

Eban's article, "The Lab-Leak Theory," is now on the Vanity Fair website and will be in a subsequent issue of the print magazine. She spent months investigating the story, conducting dozens of interviews and reviewing hundreds of pages of U.S. government documents, including internal memos, meeting minutes and emails. Eban as a contributing editor at Vanity Fair. She previously joined us to discuss her book, "Bottle Of Lies," about fraud in the generic drug industry.

Katherine Eban, welcome to FRESH AIR. Why did you start the story? What made you think that the lab leak theory had any credibility?

KATHERINE EBAN: So my editor and I were just, you know, putting our heads together and talking about now that COVID-19, at least in the U.S., was coming under some control, what were the big remaining questions of the pandemic? And one of the big remaining questions has been its origin, you know, not because of conspiracy theories, which we were intent on unpacking, but because a host animal has not been found that would support a zoonotic origin. And because of Chinese government suppression and lack of transparency, questions have not been put to rest over whether this could possibly be a lab-originated virus.

And I coupled that with the fact that the World Health Organization, on a report that it had partnered with experts on, put out this document about a couple of months ago at this point, basically saying there's no support for the lab leak theory. And the director of the World Health Organization himself said, actually, that theory is still on the table, and we don't really think that this report got to the bottom of it. So taken all of that together, it seemed to me ripe for a deep dive to look at, what are the credible questions that have not yet been answered around a possible lab leak origin?

GROSS: You write, there's reason to doubt the lab leak hypothesis, but for most of the past year, the lab leak scenario was treated not simply as unlikely or even inaccurate, but as morally out of bounds. Would you explain?

EBAN: Yeah. So the the possible hypothesis that this had originated in a laboratory became completely entangled in Trumpian politics. So in April 2020, Trump came out pretty prematurely, essentially contradicted his own intelligence agencies and put forward the idea of a lab leak. And this was from the same president, of course, who was making racist slurs against Asians and calling this the Kung Flu and had contributed to this terrible rise in violence against Asians and, here in this country, Asian Americans. So the fact that he put that out there seemed to sort of brand it as a conspiracy theory and created a kind of antibody response within the government, as one of my sources put it, you know, where people felt they were absolutely determined to fight against what they saw as a conspiracy of this magnitude.

GROSS: So let's lay out what the two main theories are. Theory one is that it jumped - the virus jumped from an animal like a bat to a human. Tell us a little bit about the scientific basis of that theory and a little bit about what the evidence is that that might be what happened...

Read more: https://www.npr.org/transcripts/1007539626
 
The remarkable diversity of bat coronaviruses

by Vincent Racaniello


All human viruses, including SARS-CoV-2, arose from spillovers from other animals. Results of a recent study of bat samples collected in a small region of Yunnan Province, China revealed additional close relatives of SARS-CoV-2 and SARS-CoV.

After the identification of SARS-CoV-2 in early 2020, wildlife sampling and retrospective genome sequencing revealed highly related viruses in animals. The virus RaTG13, from Rhinolophus affinis, shares the highest overall genome identity with SARS-CoV-2, 96.10%. The virus RmYN02 from the bat R. malayanus is the closest relative of SARS-CoV-2 in the ORF1ab open reading frame. Pangolin viruses from Guangdong have identical amino acids at six key residues in the receptor binding domain (RBD) needed for binding to human ACE2. A more distantly related coronavirus was isolated from a bat in Japan, and two viruses from Cambodia have 92.6% genome identity with SARS-CoV-2 and share five of six critical amino acids in the RBD. Finally a bat coronavirus from Thailand is closely related to RmYN02. These observations demonstrate that bats from a broad part of Asia harbor close relatives of SARS-CoV-2.

Fecal samples, oral swabs, and urine samples collected from mainly horseshoe bats in a small area of Yunnan Province between May 2019 – November 2020 were analyzed by RNA sequencing. The results revealed 9 novel betacoronaviruses and 17 alphacoronaviruses. Four of the betacoronaviruses were related to SARS-CoV-2 and three were related to SARS-CoV. Rhinolophus pusillus virus RpYN06 was the closest relative of SARS-CoV-2 in most of the genome with the exception of the spike gene. The other three SARS-CoV-2 related coronaviruses encode a spike gene that could weakly bind to the hACE2 receptor in vitro. Patches of high sequence identity in different regions of the genome illustrate the work of extensive recombination events.

While all the viruses identified in this study, as well as the previously discovered RmYN01 and RmYN02, were identified in a 1100 hectare part of Yunnan province, the results of ecological modeling show that many species of rhinolophid bats are present in much of Southeast Asia and southern China. Numerous other bat species and other wildlife inhabit this area, many of which can be infected by SARS-CoV-2. Hence much more wildlife sampling is needed to track potential spillovers of viruses into humans.

These findings also demonstrate that a very large part of Asia might harbor the direct ancestor of SARS-CoV-2. Remember that HIV/AIDS was first detected in Los Angeles in 1981 but the virus spilled over from a chimpanzee to a human in Africa in ~1920.

https://www.virology.ws/2021/06/17/the-remarkable-diversity-of-bat-coronaviruses/
 
UK scientist at centre of debate over origin of Covid pandemic 'recuses himself' from inquiry
...
By
Anne Gulland,
GLOBAL HEALTH SECURITY DEPUTY EDITOR
22 June 2021 • 12:55pm

A controversial British-born scientist has recused himself from an inquiry into the origins of the Covid pandemic amid concern over his links to a Wuhan laboratory tied to the ‘lab leak’ theory.

Dr Peter Daszak, president of the US-based EcoHealth Alliance, has “recused himself” from the inquiry by leading medical journal the Lancet after he failed to declare ties to the Wuhan Laboratory of Virology, which was conducting research into coronavirus in bats.

Dr Daszak was also a member of the WHO investigation into the source of the pandemic that issued its report earlier this year.

On the commission’s website it states that Dr Daszak has “recused himself from Commission work on the origins of the pandemic” but gives no further information.
...
Before he recused himself from the Lancet commission, which is supported by the United Nations Sustainable Development Solutions Network, Dr Daszak was one of a 12-strong international team looking at the origins of the pandemic and how future outbreaks could be prevented.
...
The Lancet Group said in a statement: “Lancet Commissions bring together leading international experts with a broad range of relevant expertise to address the most pressing issues in global health and clinical medicine.

“Commissioners are invited through a collaboration between the Chairs of the Commission and journal editors. All final decisions about Commissioners and other contributors are made by the Commission Chair.”

https://www.telegraph.co.uk/global-...ntre-pandemic-origins-debate-removed-inquiry/
 
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