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Bolivia - Unidentified viral disease in La Paz Department - 4-5 cases, 3 deaths - June 30, 2019 - arenavirus, genotype of the Chapare virus confirmed

Translation Google

Result of the first Arenavirus study will be known in 4 days


According to the Executive, of five cases with this illness, three lost their lives, one is hospitalized and the other was discharged.


SOCIETY
Friday, July 12, 2019 ? 00:37
Siete / La Paz Page

The result of the first examination to identify the type of Arenavirus that claimed the lives of three people will be sent in three or four days. The test is performed by the Center for Disease Control and Prevention (CDC) in Atlanta (USA).

In the case of the exams made to the doctors Gustavo Vidales and Marco Ortiz, the results will be sent in the next 10 or 12 days. "There is pressure on the Atlanta CDC, there is still a lapse of time to isolate the type of virus. We can not accelerate, they are laboratory processes that take time, "said Monta?o.

According to data from the Ministry of Health, of five cases registered as Arenavirus, three lost their lives (a farmer of 65 years, an internal doctor and a gastroenterologist), one is still in intensive care and one was discharged.

According to the Health report, the zero patient, Macario Gironde, started with the first symptoms of the virus on April 29. He was then admitted on May 7 and finally died on the 12th of that month in the town of Caranavi.

According to the authorities, the patient who was discharged "came out as dengue positive". "Then, it is treated as a dengue with complications. Enter intensive therapy. He recovers and leaves high, "said Monta?o.

The specialist of the Pan-American Health Organization (PAHO) Joao Toledo assured that "the outbreaks in Bolivia are few". "We know that in the 50s or 60s there was an outbreak with more than 100 deaths, but they were like 500 people who were affected," he said.

The Ministry of Health also reported that they developed protocols and contact definitions for Arenavirosis. He indicated that they also carried out an investigation since the outbreak of the first case, or the so-called zero patient, in Caranavi.

According to the authority, at present, the teams of experts continue with the research work in Guanay and Caranavi. He also indicated that they are still looking for the transmitter vector of the Arenavirus.

On Wednesday, at 8:15, the doctor Gustavo Vidales died in the intensive care room of the Obrero Hospital due to Arenavirus. He was one of the two professionals who attended the internal doctor Ximena Cuellar, who died of this illness after attending a patient who also followed the same fate in the municipality of Caranavi. According to the medical report, the cause of his death was multiple organ dysfunction, which is linked to infection with Arenavirus.

The works in Guanay and Caranavi

From putting traps to enter the mountain are some of the tasks that two teams of specialists perform to catch the mouse of the family of Calomys, transmitter of Arenavirus that claimed the lives of three people. This work has been developed for more than a week, but to date the vector has not been found.

The groups of experts have as their first task: to identify if the rodent of the genus Calomys is found in Caranavi and nearby areas. As a second mission, if the vector is detected, it must be verified if this rodent is infected by the virus.

https://www.paginasiete.bo/sociedad...l-arenavirus-se-conocera-en-dias-223962.html#!
 
So here's the issue. Machupo is supposed to have about a 15-30% fatality rate. Three of the four cases that are suspected of having this virus have died, with the fourth still ill. (The fifth case had dengue and has been discharged.) So this illness has a 75-100% CFR in this cluster. There's no evidence that any milder cases have been missed. So might we be dealing with a novel and more severe strain of arenavirus?

There is some precedent for novel fatal arenavirus discovery. Two new such viruses, Chapare in 2007 and Lujo in 2008, were discovered this century. Lujo in particular is thought to be more severe than some of the other viruses in this family, with four of the five confirmed cases having died. (Lujo is thought to be endemic only in parts of Africa, so is an unlikely suspect here, however.)

On the other hand, Lassa, which has a stated CFR below that of Machupo (as few as 1% of Lassa infections are assumed fatal, with many of them asymptomatic) has been known to kill entire families or entire medical staffs in West Africa where it is endemic. The explanation given is that these close quarters lead to high viral load infections and worse outcomes than the typical zoonotic exposure. There's also a reporting bias in that a cluster of fatal illnesses is far more likely to attract attention than a cluster with only one or even no fatalities.

So is this Machupo, or something novel? We'll know in a few days...
 
Translation Google

Results establish that the Caranavi Arenavirus is of the Chapare genotype

2019-07-15

The results of the analysis conducted by the Center for Disease Control and Prevention (CDC) of Atlanta, United States establish that the Arenavirus that was discovered in Caranavi, which claimed the lives of three people, is of the Chapare genotype. , this was reported today by the Minister of Health, Gabriela Monta?o.

"We have received the results obtained so far from the US Centers for Disease Control in Atlanta and the following technical conclusion is drawn, and confirms that he was infected with the new world Arenavirus, which is a genotype of the Chapare virus," he said. press.

That virus to date has claimed the lives of three people, a farmer, a medical intern and a physician, while a second doctor, who has that diagnosis, is still hospitalized.

The minister explained that the Atlanta report is "conclusive", but that her office will continue with the laboratory and mastozoological investigation process in Caranavi, where those cases were presented.

"These are the results that we have as new information that contributes to the entire investigation process of the Arenavirus outbreak," he added.

Monta?o took the opportunity to rule out new cases of Arenavirus in that region of the country. / Jcmh.

http://www.boliviatv.bo/principal/noticia.php?noticia=5f807cce7df3f4151aff8d7892aa3fdf&lang=es
 
Translation google

The health of Dr. Marco Ortiz affected by arenavirus improves

2019-08-15

M arco Ortiz, the doctor affected by arenavirus, has a favorable evolution. The Minister of Health, Gabriela Monta?o, said the doctor stopped breathing with the help of devices and is expected to stop intensive therapy soon.

?Dr. Ortiz presents a better condition in the field of his health. This responds to a great effort of the health personnel who attend it in intensive care. We hope that the evolution of this patient will continue as before, ?said the Minister.

He had respiratory, renal, liver failure; All these paintings began to show improvement.

Ortiz attended the internal doctor, Ximena Cuellar. She died on June 4 due to a contagion of arenavirus because she treated the ?zero patient?, Macario Gironda, a farmer who died in Caranavi, La Paz. Also the doctor Gustavo Vidales passed away, product of the same contagion.

However, the fact that Ortiz shows this favorable evolution in his health, for Monta?o shows that in Bolivia you can treat very complex patients and have good results. / JOC

http://www.boliviatv.bo/principal/noticia.php?noticia=93ea27cdd97f5199ca1602ba29c4838b&lang=es
 
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