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Discussion Thread I - 2019-nCov (new coronavirus)

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The US State Department has issued a Level 4 - Do Not Travel Advisory for all of Hubei province (which includes Wuhan)

https://mobile.twitter.com/lookner/status/1220545257730977792


Level 4: Do not travel to Hubei province, China due to novel coronavirus first identified in Wuhan, China:

There is an ongoing outbreak of pneumonia first identified in Wuhan, China, caused by a novel (new) coronavirus. In an effort to contain the novel coronavirus, the Chinese authorities have suspended air and rail travel in the area around Wuhan. On January 23, 2020, the Department of State ordered the departure of all non-emergency U.S. personnel and their family members. The U.S. government has limited ability to provide emergency services to U.S. citizens in Hubei province.

Chinese authorities have imposed strict travel restrictions in the area around Wuhan. Travelers should be aware that the Chinese government could prevent them from entering or exiting parts of Hubei province. Travelers should be prepared for travel restrictions to be put into effect with little or no advance notice.

U.S. Centers for Disease Control and Prevention has issued a Warning Level 3 Alert (Avoid Nonessential Travel) due to an ongoing outbreak of respiratory illness caused by a novel (new) coronavirus that can be spread from person to person.


more....

https://travel.state.gov/content/tr...l-Travel-Country-Information-Pages/China.html
 
https://fox17.com/news/local/tennes...sting-for-possible-infection-with-coronavirus

COOKEVILLE, Tenn. (WZTV) -- A student at Tennessee Tech University is being tested for possible infection with Coronavirus, school officials tell FOX 17 News.

According to the university, health providers quickly recognized that the student met the criteria for Coronavirus due to mild symptoms and his recent travel history, but the illness has not been confirmed.

The student is under isolation while precautionary testing is being conducted. As this happens, the university says they continue to stay in close communication with the Tennessee Department of Health.
 
That video raises serious concerns. Sounds like the way the 1917 flu suddenly affected people. I wonder if the pneumonia is caused by overreaction of the immune response like we see in novel flu strains. Low vitamin D seem to be linked with immune response causing severe pneumonia.
 
With so many Chinese nationals in our universities, those could be problem areas due to the density of students in close quarters.
 
With so many Chinese nationals in our universities, those could be problem areas due to the density of students in close quarters.

There is no evidence that people of any particular nationality are more or less susceptible to this new coronavirus. At this time, the most significant factor associated with being infected with this coronavirus is having traveled to or from Wuhan or have been in contact with sick people who have traveled to or from Hubei Province.
 

New Jersey Hospital Patient Does Not Have Coronavirus, Officials Confirm

By CBS3 StaffJanuary 23, 2020 at 11:04 pmFiled Under:coronavirus, Local, Local TV

HACKENSACK, N.J. (CBS) — The Hackensack University Medical Center confirms that after evaluation, it was determined a patient does not have coronavirus. The New Jersey Department of Health and other officials were evaluating the patient for virus.

“After an evaluation of the patient and consulting with the State Department of Health, experts have determined the patient does not have the Wuhan Coronavirus. Due to patient privacy, we are unable to provide additional information,” the hospital said in a statement.
...
https://philadelphia.cbslocal.com/2020/01/23/new-jersey-department-of-health-case-coronavirus/
 
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News media are reporting that 10 metropolitan areas in Hubei province in China (see map) are under a transportation quarantine. Together these metropolitan areas have a population exceeding 27 million people.
 

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hi - hope everyone is doing well.. my understanding, nCoV uses the ACE2 receptors. the sambucol that old folks all know and love, alters the glycoproteins in the rbd, and keeps influenza from entering the cells. now, the receptors of interest for flu are sialic acid alpha 2.3 and 2.6. does anyone know, or have a wag if the glycoprotein alteration would likewise affect nCoV entering the cells lining the airway as it does with flu?
 
actually, one more note... folks discuss airborne transmission.. CoV is roughly the size of influenza, 80nm or a little bit more. i've not seen it anywhere, but on the flu side the study below is of interest for aerosol transmission, specifically the importance of keeping indoor RH above 40% to head off formation of droplet nuclei (vs large droplet). having flu floating in dry still air for up to 24 hrs is concerning. and on the ppe side, an N95 has 300nm (.3 micron) size holes.

https://wwwnc.cdc.gov/eid/article/12/11/06-0426_article
 
C3jmp - perhaps it would be worthwhile to set up a discussion thread on PPE and to hive mind/ brainstorm the potential and drawbacks of various interventions. There are so many unknowns at present however, so a lot would be supposition based on SARS, MERS and common cold data.
 
Has WHO seen thise kinds of videos ?
There are serveral videos of people collapsing/dying in hospitals, streets etc. on Twitter.

Such videos are not verified of origin and time. Do not under estimate the power of attention seekers (click-baiters) and trolls. I do not say that all these videos are fake but should be taken with a grain of salt.
 
Source: http://www.kaixian.tv/gd/2020/0124/263113.html
Fever cough is not the only first symptom of pneumonia due to a new coronavirus infection
2020-01-24 19:45:50 Source: Xinhua News Agency

研究 Expert research by Wuhan University People's Hospital found that after infection with new type of coronavirus pneumonia, patients do not necessarily show symptoms of fever and respiratory system first, and there are also symptoms of digestive system, nervous system, cardiovascular system, ophthalmology and so on.

Wuhan University People's Hospital released on January 24th "The first symptoms of non-respiratory system are highly valued-identification and protection of patients with new type of coronavirus pneumonia (2019-nCOV)", reminding medical staff and the public to be highly vigilant about non-respiratory symptoms The first symptom of new pneumonia.

The "Notice on the Issuance of a New Coronary Virus Pneumonia Diagnosis and Treatment Plan (Trial Implementation)" issued by the authoritative department recently pointed out that the clinical manifestations of new coronavirus pneumonia are mainly manifested by fever, fatigue, and dry cough. In the multidisciplinary department of Respiratory and Critical Care Medicine, Gastroenterology, People's Hospital of Wuhan University, many cases of "atypical" cases have been discovered during the diagnosis and treatment of new pneumonia.

于 Professor Yu Honggang, director of Department of Gastroenterology, People's Hospital of Wuhan University, introduced an "atypical" case. A 45-year-old man went to the outpatient department of gastroenterology for 3 days due to diarrhea. The doctor repeatedly asked the medical history to confirm that he had a history of exposure to the new coronavirus pneumonia, but no obvious fever and related respiratory symptoms. Thorough CT was performed after the consultation between the doctor and the patient. The results showed multiple sheet-like ground glass-like shadows in both lungs, and a new coronavirus nucleic acid test in the throat swab was positive, and the diagnosis was finally confirmed.

Professor Chen Guozhong, one of the study moderators and director of the Department of Respiratory and Critical I, Wuhan University People's Hospital, introduced that in many clinical cases, the patient did not have typical respiratory symptoms such as fever and cough at the time of consultation, and only the first symptoms of digestive system symptoms: Such as mild appetite, fatigue, poor mentality, nausea, vomiting, diarrhea, etc .; first manifestations of neurological symptoms such as headache; first manifestations of cardiovascular system symptoms such as palpitation, chest tightness, etc .; first manifestations of ophthalmic symptoms such as conjunctivitis ; Only mild sore limbs or lower back muscles.

Experts reminded that the above-mentioned patients with non-respiratory system as the first performance are easy to go to relevant departments for treatment, especially in gastroenterology. The lack of obvious specific clinical manifestations increases the difficulty of diagnosis, easily leads to missed diagnosis or misdiagnosis, and increases the chance of infection. Medical staff must be alert to patients with poor appetite, fatigue, muscle soreness (including mild soreness), and mental disorders, and make timely investigations. Such "atypical" patients need to strengthen self-isolation, and medical staff should also strengthen self-protection.
 
Seeing some video of military movement. And reading whispers of martial law fears.

I’ve not come across anything official.
 
From WHO:

"They [Chinese authorities] reported fourth-generation cases in Wuhan and second-generation cases outside Wuhan, as well as some clusters outside Hubei province"
 
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