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Prog Mol Biol Transl Sci
. 2024:202:1-23.
doi: 10.1016/bs.pmbts.2023.09.001. Epub 2024 Jan 4. SARS-CoV-2-Virus structure and life cycle
Sameer Saleem Tebha 1 , Aimen Tameezuddin 2 , Sanchit Bajpai 3 , Asiya Kamber Zaidi 4
Affiliations
This book chapter presents a concise overview of SARS-CoV-2, the virus responsible for the COVID-19 pandemic. It explores viral classification based on morphology and nucleic acid composition with a focus on DNA and RNA viruses, the SARS-CoV-2 structure including the structural as well as nonstructural proteins in detail, and the viral replication mechanisms. The chapter then delves into the characteristics and diversity of coronaviruses, particularly SARS-CoV-2, highlighting its similarities with other beta-coronaviruses. The replication and transcription complex, RNA elongation, and capping, as well as the role of accessory proteins in viral replication and modulation of the host immune response is discussed extensively.
Keywords: Coronavirus; Life cycle; Non-structural proteins; SARS-CoV-2; Structural proteins; Viral genomic replication; Virus classification; Virus structure.
. 2024:202:1-23.
doi: 10.1016/bs.pmbts.2023.09.001. Epub 2024 Jan 4. SARS-CoV-2-Virus structure and life cycle
Sameer Saleem Tebha 1 , Aimen Tameezuddin 2 , Sanchit Bajpai 3 , Asiya Kamber Zaidi 4
Affiliations
- PMID: 38237982
- DOI: 10.1016/bs.pmbts.2023.09.001
This book chapter presents a concise overview of SARS-CoV-2, the virus responsible for the COVID-19 pandemic. It explores viral classification based on morphology and nucleic acid composition with a focus on DNA and RNA viruses, the SARS-CoV-2 structure including the structural as well as nonstructural proteins in detail, and the viral replication mechanisms. The chapter then delves into the characteristics and diversity of coronaviruses, particularly SARS-CoV-2, highlighting its similarities with other beta-coronaviruses. The replication and transcription complex, RNA elongation, and capping, as well as the role of accessory proteins in viral replication and modulation of the host immune response is discussed extensively.
Keywords: Coronavirus; Life cycle; Non-structural proteins; SARS-CoV-2; Structural proteins; Viral genomic replication; Virus classification; Virus structure.