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Rheumatol Autoimmun
. 2022 Dec;2(4):198-202.
doi: 10.1002/rai2.12056. Epub 2022 Oct 27.
Molecular insights into onset of autoimmunity in SARS-CoV-2 infected patients
Dama Laxminarayana 1
Affiliations
- PMID: 36714799
- PMCID: PMC9874720
- DOI: 10.1002/rai2.12056
Abstract
Some of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infected patients are facing long-term devastating effects like induction of autoimmune diseases. Here, I discuss molecular mechanisms and risk factors involved in the induction of autoimmune diseases after SARS-CoV-2 infections. Transcript editing genes were upregulated during SARS-CoV-2 infections, which might have edited host gene transcripts and paved the way for autoantigens generation and presented as nonself to generate autoantibodies followed by auto immunogenicity after SARS-CoV-2 infections. Therefore, some SARS-CoV-2 patients acquire autoimmunity. The transient and/or innocuous autoimmune response in some SARS-CoV-2 infected patients may be due to a lack of repeated production of autoantibodies to host autoantigens and/or viral antigens, which are needed to boost autoimmune response. In the future, SARS-CoV-2 mediated autoimmune disease onset will be a challenging task. Therefore, possible preventive measures and strategies to minimize and/or preclude such SARS-CoV-2 mediated autoimmune diseases have been presented in this commentary.
Keywords: RNA editing; SARS‐CoV‐2 pathogenesis; autoimmunity; cytokine storm; mutations; type I interferons.