SAGE Open Med Case Rep . COVID-19-induced latent relapsing hypercoagulable state in the absence of persistent viral infection

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SAGE Open Med Case Rep


. 2022 Jul 22;10:2050313X221113934.
doi: 10.1177/2050313X221113934. eCollection 2022.
COVID-19-induced latent relapsing hypercoagulable state in the absence of persistent viral infection


Adrija Hajra ¹ , Juan Torrado ¹ , Carlos L Alviar ² , Sripal Bangalore ² , Norma Keller ² , Robert Faillace ¹ , Seth Sokol ³



Affiliations

• PMID: 35899245
• PMCID: PMC9310331
• DOI: 10.1177/2050313X221113934

Abstract

Hypercoagulability in coronavirus disease 2019 infection is already a known fact. But in this article, we have discussed a unique case where the patient had suffered from relapsing thrombus formation. This report describes the case of a patient who presented with chronic coronavirus disease 2019-induced recurrent thrombi refractory to multiple antithrombotic regimens because of multiple recurrent inflammatory flares without any evidence of chronic persistent viral infection. The patient was treated with anticoagulation and anti-inflammatory medications. Still, he had repeated episodes of right ventricular thrombus. Coronavirus disease 2019 can provoke a severe relapsing hypercoagulable state without evidence of persisting viral infection. Rebound inflammatory flares rather than viral recurrence may play a trigger.

Keywords: COVID-19; anticoagulation; pulmonary embolism; right ventricular thrombus; thrombosis.