Future Med Chem

. 2021 Jan 20.
doi: 10.4155/fmc-2020-0226. Online ahead of print.
The potential association between PARP14 and the SARS-CoV-2 infection (COVID-19)

Amanda L Tauber 1 , Stephanie S Schweiker 1 , Stephan M Levonis 1



Understanding the potential association between the poly (ADP-ribose) polymerase member 14 (PARP14) and the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) may aid in understanding the host immunopathological response to the virus. PARP14 has an emerging role in viral infections, and this article considers its potential mechanisms for action in either a pro- or anti-viral manner. It is evident that more experimental work is required; however, PARP14 appears vital in controlling the interferon response to the SARS-CoV-2 infection and has potential roles in balancing the proinflammatory cytokines of the cytokine storm. Furthermore, the SARS-CoV-2 macrodomain can prevent the PARP14-mediated antiviral response, suggesting a more complex relationship between PARP14 activity and SARS-CoV-2 infections.

Keywords: ARTD8; COVID-19; PARP14; SARS-CoV-2; coronavirus; immunity; viral.