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Biomarkers
. 2020 Dec 7;1-17.
doi: 10.1080/1354750X.2020.1861099. Online ahead of print.
The Receptor for Advanced Glycation End Product (RAGE) Pathway in COVID-19
Demet Yalcin Kehribar 1 , Mustafa Cihangiroglu 2 , Emine Sehmen 3 , Bahattin Avci 4 , Aylin Capraz 2 , Ayse Yildirim Bilgin 2 , Caner Gunaydin 5 , Metin Ozgen 5
Affiliations
- PMID: 33284049
- DOI: 10.1080/1354750X.2020.1861099
Abstract
Introduction: Coronavirus disease-2019 (COVID-19) with lung involvement frequently causes morbidity and mortality. Advanced age appears to be the most important risk factor. The receptor for advanced glycation end-product (RAGE) pathway is considered to play important roles in the physiological aging and pathogenesis of lung diseases. This study aims to investigate the possible relationship between COVID-19 and RAGE pathway.
Materials and methods: This study included 23 asymptomatic patients and 35 patients with lung involvement who were diagnosed with COVID-19 as well as 22 healthy volunteers. Lung involvement was determined using computed-tomography. Serum soluble-RAGE (sRAGE) levels were determined using enzyme-linked immunosorbent assay.
Results: The sRAGE levels were significantly higher in the asymptomatic group than in the control group. Age, fibrinogen, C-reactive protein, and ferritin levels were higher and the sRAGE level was lower in the patients with lung involvement than in the asymptomatic patients.
Conclusions: In the present study, patients with high sRAGE levels were younger and had asymptomatic COVID-19. Patients with low sRAGE levels were elderly patients with lung involvement, which indicates that the RAGE pathway plays an important role in the aggravation of COVID-19.
Keywords: Aging; COVID-19; Co-morbidity; Infection; Inflammation; The receptor for advanced glycation end product (RAGE).