Infect Drug Resist . Effect of SARS-CoV-2 Infection on the Microbial Composition of Upper Airway

[tetano]

Infect Drug Resist


. 2020 Jul 31;13:2637-2640.
doi: 10.2147/IDR.S259984. eCollection 2020.
Effect of SARS-CoV-2 Infection on the Microbial Composition of Upper Airway


Zhenguo Wang ^{# 1} , Xiaojun Hu ^{# 2} , Zhonghe Li ^{# 3} , Changli Tu ¹ , Yiming Wang ⁴ , Pengfei Pang ² , Huitao Zhang ^{# 2} , Xiaobin Zheng ¹ , Yingjian Liang ¹ , Hong Shan ² , Jing Liu ¹



Affiliations

• PMID: 32801801
• PMCID: PMC7406177
• DOI: 10.2147/IDR.S259984

Abstract

Methods: Forty-four COVID-19 patients (severe/critical: N = 8, non-severe: N = 36) were examined by next generation sequencing (NGS) of nasopharyngeal test paper to observe the effect of novel coronavirus infection to the microbial composition in upper airway.
Results: In these nasopharyngeal test paper samples, 38 kinds of bacteria, 10 kinds of viruses except SARS-CoV-2, nine kinds of fungi and three kinds of atypical pathogens had been found. There was some difference in microbial composition in the upper airway between severe and non-severe cases.
Summary: These results are important for us to study the effect of SARS-CoV-2 on the local microbial composition of upper airway and prevent opportunistic infection in severe patients.

Keywords: SARS-CoV-2; microbial composition; next generation sequencing; NGS; upper airway.