Announcement

Collapse
No announcement yet.

J Med Virol . Subversion of Host Stress Granules by Coronaviruses: Potential Roles of π-rich Disordered Domains of Viral Nucleocapsids

Collapse
X
Collapse
 
  • Page of 1
  • Filter
  • Time
  • Show
Clear All
new posts
Previous template Next
  • #1

    J Med Virol . Subversion of Host Stress Granules by Coronaviruses: Potential Roles of π-rich Disordered Domains of Viral Nucleocapsids


    J Med Virol


    . 2020 Jun 19.
    doi: 10.1002/jmv.26195. Online ahead of print.
    Subversion of Host Stress Granules by Coronaviruses: Potential Roles of π-rich Disordered Domains of Viral Nucleocapsids


    Mahdi Muhammad Moosa 1 , Priya R Banerjee 1



    Affiliations

    Abstract

    Coronavirus nucleocapsids (CoV N's) play both structural and non-structural roles in viral life-cycle. Here, we propose a mechanism for host stress granule (SG) subversion by CoV N proteins. We posit that disordered domains of CoV N's can engage in π-π intermolecular fuzzy interactions with host SG proteins and are crucial to the viral hijacking of host machineries. This article is protected by copyright. All rights reserved.

    Keywords: 2019-nCoV; COVID-19; Coronavirus nucleocapsid; Host-virus interaction; IDR interaction; Nucleocapsid interactome; Phase separation propensity; Stress granule hijacking.

    Tags: None
Previous template Next
Working...
X