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Vaccine
. 2024 Feb 22:S0264-410X(24)00215-9.
doi: 10.1016/j.vaccine.2024.02.056. Online ahead of print. Influenza vaccine effectiveness against hospitalizations associated with influenza A(H3N2) in Hong Kong children aged 9 months to 17 years, June-November 2023
Caitriona Murphy 1 , Mike Y W Kwan 2 , Eunice L Y Chan 3 , Joshua S C Wong 2 , Sheena G Sullivan 4 , Malik Peiris 5 , Benjamin J Cowling 6 , So-Lun Lee 7
Affiliations
A test negative study was carried out from 13 June through to 15 November 2023 enrolling 3183 children hospitalized with acute respiratory illness in Hong Kong. Influenza A and B viruses were detected in 528 (16.6%) children, among which 419 (79.4%) were influenza A(H3N2). The overall vaccine effectiveness against hospitalization associated with any influenza virus infection was estimated as 22.4% (95% CI: -11.7%, 46.1%), and against influenza A(H3N2) specifically was 14.3% (95% CI: -29.2%, 43.2%). Despite the moderate to low VE estimated here, which could be a result of waning immunity and antigenic drift, influenza vaccination remains an important approach to reduce the impact of influenza in children.
Keywords: H3N2; Influenza; Vaccination; Vaccine effectiveness.
. 2024 Feb 22:S0264-410X(24)00215-9.
doi: 10.1016/j.vaccine.2024.02.056. Online ahead of print. Influenza vaccine effectiveness against hospitalizations associated with influenza A(H3N2) in Hong Kong children aged 9 months to 17 years, June-November 2023
Caitriona Murphy 1 , Mike Y W Kwan 2 , Eunice L Y Chan 3 , Joshua S C Wong 2 , Sheena G Sullivan 4 , Malik Peiris 5 , Benjamin J Cowling 6 , So-Lun Lee 7
Affiliations
- PMID: 38395722
- DOI: 10.1016/j.vaccine.2024.02.056
A test negative study was carried out from 13 June through to 15 November 2023 enrolling 3183 children hospitalized with acute respiratory illness in Hong Kong. Influenza A and B viruses were detected in 528 (16.6%) children, among which 419 (79.4%) were influenza A(H3N2). The overall vaccine effectiveness against hospitalization associated with any influenza virus infection was estimated as 22.4% (95% CI: -11.7%, 46.1%), and against influenza A(H3N2) specifically was 14.3% (95% CI: -29.2%, 43.2%). Despite the moderate to low VE estimated here, which could be a result of waning immunity and antigenic drift, influenza vaccination remains an important approach to reduce the impact of influenza in children.
Keywords: H3N2; Influenza; Vaccination; Vaccine effectiveness.