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Influenza Other Respir Viruses
. 2024 Jan 10;18(1):e13243.
doi: 10.1111/irv.13243. eCollection 2024 Jan. Influenza vaccine effectiveness in Europe: Results from the 2022-2023 VEBIS (Vaccine Effectiveness, Burden and Impact Studies) primary care multicentre study
Marine Maurel 1 , Francisco Pozo 2 3 , Gloria Pérez-Gimeno 2 3 , Silke Buda 4 , Noémie Sève 5 , Beatrix Oroszi 6 , Mariette Hooiveld 7 , Verónica Gomez 8 , Lisa Domegan 9 , Iván Martínez-Baz 3 10 , Maja Ilić 11 , Anna Sara Carnahan 12 , Maria Elena Mihai 13 , Ana Martínez 14 , Luise Goerlitz 4 , Vincent Enouf 15 , Judit Krisztina Horváth 6 , Frederika Dijkstra 16 , Ana Paula Rodrigues 8 , Charlene Bennett 17 , Camino Trobajo-Sanmartín 3 10 , Ivan Mlinarić 11 , Neus Latorre-Margalef 12 , Alina Ivanciuc 13 , Aurora Lopez 18 , Ralf Dürrwald 19 , Alessandra Falchi 20 , Gergő Túri 6 , Adam Meijer 16 , Aryse Melo 8 , Joan O'Donnell 9 , Jesús Castilla 3 10 , Vesna Višekruna Vučina 11 , Tove Samuelsson Hagey 12 , Mihaela Lazar 13 , Marlena Kaczmarek 21 , Sabrina Bacci 21 , Esther Kissling 1 ; VEBIS study team
Affiliations
Background: Influenza A(H3N2) viruses dominated early in the 2022-2023 influenza season in Europe, followed by higher circulation of influenza A(H1N1)pdm09 and B viruses. The VEBIS primary care network estimated the influenza vaccine effectiveness (VE) using a multicentre test-negative study.
Materials and methods: Primary care practitioners collected information and specimens from patients consulting with acute respiratory infection. We measured VE against any influenza, influenza (sub)type and clade, by age group, by influenza vaccine target group and by time since vaccination, using logistic regression.
Results: We included 38 058 patients, of which 3786 were influenza A(H3N2), 1548 influenza A(H1N1)pdm09 and 3275 influenza B cases. Against influenza A(H3N2), VE was 36% (95% CI: 25-45) among all ages and ranged between 30% and 52% by age group and target group. VE against influenza A(H3N2) clade 2b was 38% (95% CI: 25-49). Overall, VE against influenza A(H1N1)pdm09 was 46% (95% CI: 35-56) and ranged between 29% and 59% by age group and target group. VE against influenza A(H1N1)pdm09 clade 5a.2a was 56% (95% CI: 46-65) and 79% (95% CI: 64-88) against clade 5a.2a.1. VE against influenza B was 76% (95% CI: 70-81); overall, 84%, 72% and 71% were among 0-14-year-olds, 15-64-year-olds and those in the influenza vaccination target group, respectively. VE against influenza B with a position 197 mutation of the hemagglutinin (HA) gene was 79% (95% CI: 73-85) and 90% (95% CI: 85-94) without this mutation.
Conclusion: The 2022-2023 end-of-season results from the VEBIS network at primary care level showed high VE among children and against influenza B, with lower VE against influenza A(H1N1)pdm09 and A(H3N2).
Keywords: Europe; influenza; influenza vaccine; multicentre study; vaccine effectiveness.
. 2024 Jan 10;18(1):e13243.
doi: 10.1111/irv.13243. eCollection 2024 Jan. Influenza vaccine effectiveness in Europe: Results from the 2022-2023 VEBIS (Vaccine Effectiveness, Burden and Impact Studies) primary care multicentre study
Marine Maurel 1 , Francisco Pozo 2 3 , Gloria Pérez-Gimeno 2 3 , Silke Buda 4 , Noémie Sève 5 , Beatrix Oroszi 6 , Mariette Hooiveld 7 , Verónica Gomez 8 , Lisa Domegan 9 , Iván Martínez-Baz 3 10 , Maja Ilić 11 , Anna Sara Carnahan 12 , Maria Elena Mihai 13 , Ana Martínez 14 , Luise Goerlitz 4 , Vincent Enouf 15 , Judit Krisztina Horváth 6 , Frederika Dijkstra 16 , Ana Paula Rodrigues 8 , Charlene Bennett 17 , Camino Trobajo-Sanmartín 3 10 , Ivan Mlinarić 11 , Neus Latorre-Margalef 12 , Alina Ivanciuc 13 , Aurora Lopez 18 , Ralf Dürrwald 19 , Alessandra Falchi 20 , Gergő Túri 6 , Adam Meijer 16 , Aryse Melo 8 , Joan O'Donnell 9 , Jesús Castilla 3 10 , Vesna Višekruna Vučina 11 , Tove Samuelsson Hagey 12 , Mihaela Lazar 13 , Marlena Kaczmarek 21 , Sabrina Bacci 21 , Esther Kissling 1 ; VEBIS study team
Affiliations
- PMID: 38204584
- PMCID: PMC10777262
- DOI: 10.1111/irv.13243
Background: Influenza A(H3N2) viruses dominated early in the 2022-2023 influenza season in Europe, followed by higher circulation of influenza A(H1N1)pdm09 and B viruses. The VEBIS primary care network estimated the influenza vaccine effectiveness (VE) using a multicentre test-negative study.
Materials and methods: Primary care practitioners collected information and specimens from patients consulting with acute respiratory infection. We measured VE against any influenza, influenza (sub)type and clade, by age group, by influenza vaccine target group and by time since vaccination, using logistic regression.
Results: We included 38 058 patients, of which 3786 were influenza A(H3N2), 1548 influenza A(H1N1)pdm09 and 3275 influenza B cases. Against influenza A(H3N2), VE was 36% (95% CI: 25-45) among all ages and ranged between 30% and 52% by age group and target group. VE against influenza A(H3N2) clade 2b was 38% (95% CI: 25-49). Overall, VE against influenza A(H1N1)pdm09 was 46% (95% CI: 35-56) and ranged between 29% and 59% by age group and target group. VE against influenza A(H1N1)pdm09 clade 5a.2a was 56% (95% CI: 46-65) and 79% (95% CI: 64-88) against clade 5a.2a.1. VE against influenza B was 76% (95% CI: 70-81); overall, 84%, 72% and 71% were among 0-14-year-olds, 15-64-year-olds and those in the influenza vaccination target group, respectively. VE against influenza B with a position 197 mutation of the hemagglutinin (HA) gene was 79% (95% CI: 73-85) and 90% (95% CI: 85-94) without this mutation.
Conclusion: The 2022-2023 end-of-season results from the VEBIS network at primary care level showed high VE among children and against influenza B, with lower VE against influenza A(H1N1)pdm09 and A(H3N2).
Keywords: Europe; influenza; influenza vaccine; multicentre study; vaccine effectiveness.