Anal Methods . Development and validation of a mass spectrometry based analytical method to quantify the ratios in hemagglutinin trimers in quadrivalent influenza nanoparticle vaccine - FluMos-v1 - FluTrackers News and Information

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Anal Methods . Development and validation of a mass spectrometry based analytical method to quantify the ratios in hemagglutinin trimers in quadrivalent influenza nanoparticle vaccine - FluMos-v1

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tetano

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Anal Methods . Development and validation of a mass spectrometry based analytical method to quantify the ratios in hemagglutinin trimers in quadrivalent influenza nanoparticle vaccine - FluMos-v1

February 4, 2023, 03:34 AM

Anal Methods

. 2023 Feb 1.
doi: 10.1039/d2ay01890j. Online ahead of print.
Development and validation of a mass spectrometry based analytical method to quantify the ratios in hemagglutinin trimers in quadrivalent influenza nanoparticle vaccine - FluMos-v1

Asif Shajahan¹, Cindy X Cai¹, Jeremy Wolff¹, R Sylvie Yang¹, Vera B Ivleva¹, Daniel B Gowetski¹, Jason G D Gall¹, Q Paula Lei¹

Affiliations
PMID: 36723411

DOI: 10.1039/d2ay01890j

Abstract

A quadrivalent influenza nanoparticle vaccine (FluMos-v1) offers long-lasting protection against multiple influenza virus strains and is composed of four strains of hemagglutinin trimer (HAT) assembled around a pentamer core. Here we report an LC-MS/MS analytical development and validation method to measure the percentage of each HAT component in FluMos-v1.

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