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Cell Rep. 2019 Feb 26;26(9):2307-2315.e5. doi: 10.1016/j.celrep.2019.01.104.
Influenza Vaccination Induces NK-Cell-Mediated Type-II IFN Response that Regulates Humoral Immunity in an IL-6-Dependent Manner.
Farsakoglu Y1, Palomino-Segura M1, Latino I2, Zanaga S2, Chatziandreou N2, Pizzagalli DU3, Rinaldi A4, Bolis M5, Sallusto F6, Stein JV7, Gonzalez SF8.
Author information
Abstract
The role of natural killer (NK) cells in the immune response against vaccines is not fully understood. Here, we examine the function of infiltrated NK cells in the initiation of the inflammatory response triggered by inactivated influenza virus vaccine in the draining lymph node (LN). We observed that, following vaccination, NK cells are recruited to the interfollicular and medullary areas of the LN and become activated by type I interferons (IFNs) produced by LN macrophages. The activation of NK cells leads to their early production of IFNγ, which in turn regulates the recruitment of IL-6+ CD11b+ dendritic cells. Finally, we demonstrate that the interleukin-6 (IL-6)-mediated inflammation is important for the development of an effective humoral response against influenza virus in the draining LN.
Copyright ? 2019 The Authors. Published by Elsevier Inc. All rights reserved.
KEYWORDS:
IFNγ; IL-6; dendritic cell; influenza vaccine; natural killer cell; type I IFN
PMID: 30811982 DOI: 10.1016/j.celrep.2019.01.104
Influenza Vaccination Induces NK-Cell-Mediated Type-II IFN Response that Regulates Humoral Immunity in an IL-6-Dependent Manner.
Farsakoglu Y1, Palomino-Segura M1, Latino I2, Zanaga S2, Chatziandreou N2, Pizzagalli DU3, Rinaldi A4, Bolis M5, Sallusto F6, Stein JV7, Gonzalez SF8.
Author information
Abstract
The role of natural killer (NK) cells in the immune response against vaccines is not fully understood. Here, we examine the function of infiltrated NK cells in the initiation of the inflammatory response triggered by inactivated influenza virus vaccine in the draining lymph node (LN). We observed that, following vaccination, NK cells are recruited to the interfollicular and medullary areas of the LN and become activated by type I interferons (IFNs) produced by LN macrophages. The activation of NK cells leads to their early production of IFNγ, which in turn regulates the recruitment of IL-6+ CD11b+ dendritic cells. Finally, we demonstrate that the interleukin-6 (IL-6)-mediated inflammation is important for the development of an effective humoral response against influenza virus in the draining LN.
Copyright ? 2019 The Authors. Published by Elsevier Inc. All rights reserved.
KEYWORDS:
IFNγ; IL-6; dendritic cell; influenza vaccine; natural killer cell; type I IFN
PMID: 30811982 DOI: 10.1016/j.celrep.2019.01.104