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Vaccine. 2018 Jul 26. pii: S0264-410X(18)30987-3. doi: 10.1016/j.vaccine.2018.07.021. [Epub ahead of print]
Significant circulation of influenza B viruses mismatching the recommended vaccine-lineage in South Korea, 2007-2014.
Noh JY1, Choi WS1, Song JY1, Lee HS2, Lim S2, Lee J3, Seo YB3, Lee JS4, Wie SH5, Jeong HW6, Heo JY6, Kim YK7, Park KH8, Kim SW9, Lee SH10, Lee JH11, Kim DH12, Woo SI13, Lim CS14, Cho KS15, Cheong HJ1, Kim WJ16.
Author information
Abstract
We aimed to characterize the lineages of influenza B viruses obtained from clinical specimens during the 2007-2014 seasons in South Korea. RT-PCR for the partial hemagglutinin gene of influenza B virus was performed on laboratory-confirmed influenza B samples from the 2007-2008 season to 2013-2014 season. A phylogenetic tree was generated, and current influenza vaccine strains for the Northern Hemisphere were used as representative strains of Victoria and Yamagata lineages. A total of 571 influenza B virus sequences were analyzed. During the 2009-2010 season, most of the circulating influenza B viruses matched the vaccine strain; 91.0% (91/100) of viruses belonged to the Victoria lineage. In the 2007-2008, 2011-2012, and 2013-2014 seasons, co-circulation of each influenza B lineage was found with a match ratio to the vaccine strain of 53.2% (42/79), 40.9% (63/154), and 58.3% (134/230), respectively. Overall, 41.7% (238/571) of the circulating influenza B viruses belonged to the lineage mismatching the vaccine strain. During the seven influenza seasons, influenza B epidemics were substantial in four seasons in South Korea. Significant mismatches of the vaccine and lineage of the circulating influenza B viruses were found. The current trivalent influenza vaccine may not be fully suitable for effective protection against influenza B.
KEYWORDS:
Epidemiology; Influenza B virus
PMID: 30057284 DOI: 10.1016/j.vaccine.2018.07.021
Significant circulation of influenza B viruses mismatching the recommended vaccine-lineage in South Korea, 2007-2014.
Noh JY1, Choi WS1, Song JY1, Lee HS2, Lim S2, Lee J3, Seo YB3, Lee JS4, Wie SH5, Jeong HW6, Heo JY6, Kim YK7, Park KH8, Kim SW9, Lee SH10, Lee JH11, Kim DH12, Woo SI13, Lim CS14, Cho KS15, Cheong HJ1, Kim WJ16.
Author information
Abstract
We aimed to characterize the lineages of influenza B viruses obtained from clinical specimens during the 2007-2014 seasons in South Korea. RT-PCR for the partial hemagglutinin gene of influenza B virus was performed on laboratory-confirmed influenza B samples from the 2007-2008 season to 2013-2014 season. A phylogenetic tree was generated, and current influenza vaccine strains for the Northern Hemisphere were used as representative strains of Victoria and Yamagata lineages. A total of 571 influenza B virus sequences were analyzed. During the 2009-2010 season, most of the circulating influenza B viruses matched the vaccine strain; 91.0% (91/100) of viruses belonged to the Victoria lineage. In the 2007-2008, 2011-2012, and 2013-2014 seasons, co-circulation of each influenza B lineage was found with a match ratio to the vaccine strain of 53.2% (42/79), 40.9% (63/154), and 58.3% (134/230), respectively. Overall, 41.7% (238/571) of the circulating influenza B viruses belonged to the lineage mismatching the vaccine strain. During the seven influenza seasons, influenza B epidemics were substantial in four seasons in South Korea. Significant mismatches of the vaccine and lineage of the circulating influenza B viruses were found. The current trivalent influenza vaccine may not be fully suitable for effective protection against influenza B.
KEYWORDS:
Epidemiology; Influenza B virus
PMID: 30057284 DOI: 10.1016/j.vaccine.2018.07.021