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J Immunol Methods. 2018 Apr 20. pii: S0022-1759(18)30030-9. doi: 10.1016/j.jim.2018.04.008. [Epub ahead of print]
Relationship between the frequency of influenza vaccination and cell-mediated immunity.
Otani N1, Shima M2, Ueda T3, Ichiki K3, Nakajima K3, Takesue Y3, Honjo K4, Yoshida N4, Kawata S4, Okuno T5.
Author information
Abstract
Despite established guidelines for population-level assessments of immunity after vaccination, standard methods for individual-level analyses have not been established, limiting the ability to optimize vaccination strategies within a particular season. In this study, we evaluated changes in cell-mediated immunity (CMI) with respect to the number of influenza vaccine doses. In particular, the influenza vaccine was administered to 21 adults during the 2015-2016 season. IFN-γ production induced by the influenza vaccine antigens [A (H1N1), A (H3N2), B (Yamagata lineage), and B (Victoria lineage)] increased after the first dose of vaccination in 11, 10, 10, and 11 subjects, respectively. In 5 of 10 (H1N1), 4 of 10 (H3N2), 3 of 9 (Yamagata lineage), and 3 of 8 (Victoria lineage) subjects who did not exhibit an increase in IFN-γ production after the first dose, CMI was enhanced after the second dose. The production of IFN-γ increased after the first or second dose of the vaccine in 16, 14, 13, and 14 of the 21 subjects, respectively. The results of this study showed that two doses of the influenza vaccine effectively enhance CMI in subjects with primary vaccine failure.
KEYWORDS:
Cell-mediated immunity; Hemagglutination inhibition; IFN-γ; Influenza vaccine; Neutralizing antibody
PMID: 29684427 DOI: 10.1016/j.jim.2018.04.008
Relationship between the frequency of influenza vaccination and cell-mediated immunity.
Otani N1, Shima M2, Ueda T3, Ichiki K3, Nakajima K3, Takesue Y3, Honjo K4, Yoshida N4, Kawata S4, Okuno T5.
Author information
Abstract
Despite established guidelines for population-level assessments of immunity after vaccination, standard methods for individual-level analyses have not been established, limiting the ability to optimize vaccination strategies within a particular season. In this study, we evaluated changes in cell-mediated immunity (CMI) with respect to the number of influenza vaccine doses. In particular, the influenza vaccine was administered to 21 adults during the 2015-2016 season. IFN-γ production induced by the influenza vaccine antigens [A (H1N1), A (H3N2), B (Yamagata lineage), and B (Victoria lineage)] increased after the first dose of vaccination in 11, 10, 10, and 11 subjects, respectively. In 5 of 10 (H1N1), 4 of 10 (H3N2), 3 of 9 (Yamagata lineage), and 3 of 8 (Victoria lineage) subjects who did not exhibit an increase in IFN-γ production after the first dose, CMI was enhanced after the second dose. The production of IFN-γ increased after the first or second dose of the vaccine in 16, 14, 13, and 14 of the 21 subjects, respectively. The results of this study showed that two doses of the influenza vaccine effectively enhance CMI in subjects with primary vaccine failure.
KEYWORDS:
Cell-mediated immunity; Hemagglutination inhibition; IFN-γ; Influenza vaccine; Neutralizing antibody
PMID: 29684427 DOI: 10.1016/j.jim.2018.04.008