Tweet
Int J Gynaecol Obstet. 2017 Nov 17. doi: 10.1002/ijgo.12394. [Epub ahead of print]
A systematic review and meta-analysis of fetal outcomes following the administration of influenza A/H1N1 vaccination during pregnancy.
Zhang C1,2,3, Wang X3,4, Liu D1,2,3, Zhang L1,2,3, Sun X5.
Author information
Abstract
BACKGROUND:
Pregnant women were identified as a population of priority for vaccination during the H1N1 influenza pandemic breaking out in 2009.
OBJECTIVES:
To assess adverse fetal outcomes following the administration of H1N1 pandemic vaccination during pregnancy.
SEARCH STRATEGY:
PubMed, Embase, and Cochrane Library were searched up to January 2017.
SELECTION CRITERIA:
Cohort studies investigating fetal outcomes after H1N1 influenza vaccination during pregnancy were eligible. The language was limited to English.
DATA COLLECTION AND ANALYSIS:
Pairs of reviewers independently screened studies for eligibility, assessed the risk of bias, and extracted data from the included studies.
MAIN RESULTS:
A total of 19 cohort studies were eligible. The use of vaccines during any period of pregnancy was associated with lower risk of stillbirth (adjusted hazard ratio 0.80, 95% confidence interval 0.69-0.92). No significant differences were found between the vaccinated versus unvaccinated groups in terms of the risks of spontaneous abortion, premature birth, and small for gestational age.
CONCLUSIONS:
The administration of H1N1 vaccines during pregnancy might reduce the risk of stillbirth, a complication associated with H1N1 infection. The quality of evidence was, however, not adequate to reach a definitive conclusion. This article is protected by copyright. All rights reserved.
This article is protected by copyright. All rights reserved.
KEYWORDS:
A/H1N1 pandemic vaccination; Congenital malformation; Fetal outcomes; Meta-analysis; Premature delivery; Stillbirth
PMID: 29149524 DOI: 10.1002/ijgo.12394
A systematic review and meta-analysis of fetal outcomes following the administration of influenza A/H1N1 vaccination during pregnancy.
Zhang C1,2,3, Wang X3,4, Liu D1,2,3, Zhang L1,2,3, Sun X5.
Author information
Abstract
BACKGROUND:
Pregnant women were identified as a population of priority for vaccination during the H1N1 influenza pandemic breaking out in 2009.
OBJECTIVES:
To assess adverse fetal outcomes following the administration of H1N1 pandemic vaccination during pregnancy.
SEARCH STRATEGY:
PubMed, Embase, and Cochrane Library were searched up to January 2017.
SELECTION CRITERIA:
Cohort studies investigating fetal outcomes after H1N1 influenza vaccination during pregnancy were eligible. The language was limited to English.
DATA COLLECTION AND ANALYSIS:
Pairs of reviewers independently screened studies for eligibility, assessed the risk of bias, and extracted data from the included studies.
MAIN RESULTS:
A total of 19 cohort studies were eligible. The use of vaccines during any period of pregnancy was associated with lower risk of stillbirth (adjusted hazard ratio 0.80, 95% confidence interval 0.69-0.92). No significant differences were found between the vaccinated versus unvaccinated groups in terms of the risks of spontaneous abortion, premature birth, and small for gestational age.
CONCLUSIONS:
The administration of H1N1 vaccines during pregnancy might reduce the risk of stillbirth, a complication associated with H1N1 infection. The quality of evidence was, however, not adequate to reach a definitive conclusion. This article is protected by copyright. All rights reserved.
This article is protected by copyright. All rights reserved.
KEYWORDS:
A/H1N1 pandemic vaccination; Congenital malformation; Fetal outcomes; Meta-analysis; Premature delivery; Stillbirth
PMID: 29149524 DOI: 10.1002/ijgo.12394