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Protein Eng Des Sel. 2016 Jun 16. pii: gzw017. [Epub ahead of print]
Influenza evolution and H3N2 vaccine effectiveness, with application to the 2014/2015 season.
Li X1, Deem MW2.
Author information
Abstract
Influenza A is a serious disease that causes significant morbidity and mortality, and vaccines against the seasonal influenza disease are of variable effectiveness. In this article, we discuss the use of the pepitope method to predict the dominant influenza strain and the expected vaccine effectiveness in the coming flu season. We illustrate how the effectiveness of the 2014/2015 A/Texas/50/2012 [clade 3C.1] vaccine against the A/California/02/2014 [clade 3C.3a] strain that emerged in the population can be estimated via pepitope In addition, we show by a multidimensional scaling analysis of data collected through 2014, the emergence of a new A/New Mexico/11/2014-like cluster [clade 3C.2a] that is immunologically distinct from the A/California/02/2014-like strains.
? The Author 2016. Published by Oxford University Press.
KEYWORDS:
dominant strains; influenza evolution; pepitope; phylogeny; vaccine effectiveness
PMID: 27313229 [PubMed - as supplied by publisher] Free full text
Influenza evolution and H3N2 vaccine effectiveness, with application to the 2014/2015 season.
Li X1, Deem MW2.
Author information
Abstract
Influenza A is a serious disease that causes significant morbidity and mortality, and vaccines against the seasonal influenza disease are of variable effectiveness. In this article, we discuss the use of the pepitope method to predict the dominant influenza strain and the expected vaccine effectiveness in the coming flu season. We illustrate how the effectiveness of the 2014/2015 A/Texas/50/2012 [clade 3C.1] vaccine against the A/California/02/2014 [clade 3C.3a] strain that emerged in the population can be estimated via pepitope In addition, we show by a multidimensional scaling analysis of data collected through 2014, the emergence of a new A/New Mexico/11/2014-like cluster [clade 3C.2a] that is immunologically distinct from the A/California/02/2014-like strains.
? The Author 2016. Published by Oxford University Press.
KEYWORDS:
dominant strains; influenza evolution; pepitope; phylogeny; vaccine effectiveness
PMID: 27313229 [PubMed - as supplied by publisher] Free full text