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Pediatrics. 2016 Jan 5. pii: peds.2015-3279. [Epub ahead of print]
Seasonal Effectiveness of Live Attenuated and Inactivated Influenza Vaccine.
Chung JR1, Flannery B2, Thompson MG2, Gaglani M3, Jackson ML4, Monto AS5, Nowalk MP6, Talbot HK7, Treanor JJ8, Belongia EA9, Murthy K3, Jackson LA4, Petrie JG5, Zimmerman RK6, Griffin MR7, McLean HQ9, Fry AM2.
Author information
Abstract
BACKGROUND:
Few observational studies have evaluated the relative effectiveness of live attenuated (LAIV) and inactivated (IIV) influenza vaccines against medically attended laboratory-confirmed influenza.
METHODS:
We analyzed US Influenza Vaccine Effectiveness Network data from participants aged 2 to 17 years during 4 seasons (2010-2011 through 2013-2014) to compare relative effectiveness of LAIV and IIV against influenza-associated illness. Vaccine receipt was confirmed via provider/electronic medical records or immunization registry. We calculated the ratio (odds) of influenza-positive to influenza-negative participants among those age-appropriately vaccinated with either LAIV or IIV for the corresponding season. We examined relative effectiveness of LAIV and IIV by using adjusted odds ratios (ORs) and 95% confidence intervals (CIs) from logistic regression.
RESULTS:
Of 6819 participants aged 2 to 17 years, 2703 were age-appropriately vaccinated with LAIV (n = 637) or IIV (n = 2066). Odds of influenza were similar for LAIV and IIV recipients during 3 seasons (2010-2011 through 2012-2013). In 2013-2014, odds of influenza were significantly higher among LAIV recipients compared with IIV recipients 2 to 8 years old (OR 5.36; 95% CI, 2.37 to 12.13). Participants vaccinated with LAIV or IIV had similar odds of illness associated with influenza A/H3N2 or B. LAIV recipients had greater odds of illness due to influenza A/H1N1pdm09 in 2010-2011 and 2013-2014.
CONCLUSIONS:
We observed lower effectiveness of LAIV compared with IIV against influenza A/H1N1pdm09 but not A(H3N2) or B among children and adolescents, suggesting poor performance related to the LAIV A/H1N1pdm09 viral construct.
Copyright ? 2016 by the American Academy of Pediatrics.
PMID: 26738884 [PubMed - as supplied by publisher]
Seasonal Effectiveness of Live Attenuated and Inactivated Influenza Vaccine.
Chung JR1, Flannery B2, Thompson MG2, Gaglani M3, Jackson ML4, Monto AS5, Nowalk MP6, Talbot HK7, Treanor JJ8, Belongia EA9, Murthy K3, Jackson LA4, Petrie JG5, Zimmerman RK6, Griffin MR7, McLean HQ9, Fry AM2.
Author information
Abstract
BACKGROUND:
Few observational studies have evaluated the relative effectiveness of live attenuated (LAIV) and inactivated (IIV) influenza vaccines against medically attended laboratory-confirmed influenza.
METHODS:
We analyzed US Influenza Vaccine Effectiveness Network data from participants aged 2 to 17 years during 4 seasons (2010-2011 through 2013-2014) to compare relative effectiveness of LAIV and IIV against influenza-associated illness. Vaccine receipt was confirmed via provider/electronic medical records or immunization registry. We calculated the ratio (odds) of influenza-positive to influenza-negative participants among those age-appropriately vaccinated with either LAIV or IIV for the corresponding season. We examined relative effectiveness of LAIV and IIV by using adjusted odds ratios (ORs) and 95% confidence intervals (CIs) from logistic regression.
RESULTS:
Of 6819 participants aged 2 to 17 years, 2703 were age-appropriately vaccinated with LAIV (n = 637) or IIV (n = 2066). Odds of influenza were similar for LAIV and IIV recipients during 3 seasons (2010-2011 through 2012-2013). In 2013-2014, odds of influenza were significantly higher among LAIV recipients compared with IIV recipients 2 to 8 years old (OR 5.36; 95% CI, 2.37 to 12.13). Participants vaccinated with LAIV or IIV had similar odds of illness associated with influenza A/H3N2 or B. LAIV recipients had greater odds of illness due to influenza A/H1N1pdm09 in 2010-2011 and 2013-2014.
CONCLUSIONS:
We observed lower effectiveness of LAIV compared with IIV against influenza A/H1N1pdm09 but not A(H3N2) or B among children and adolescents, suggesting poor performance related to the LAIV A/H1N1pdm09 viral construct.
Copyright ? 2016 by the American Academy of Pediatrics.
PMID: 26738884 [PubMed - as supplied by publisher]