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Methods Mol Biol. 2015;1343:107-14. doi: 10.1007/978-1-4939-2963-4_9.
Activation-Induced Cytidine Deaminase and Switched Memory B Cells as Predictors of Effective In Vivo Responses to the Influenza Vaccine.
Frasca D1, Diaz A2, Blomberg BB2.
Author information
Abstract
Aging impairs humoral immune responses, leading to increased frequency and severity of infectious diseases and reduced protective effects of vaccination. We have identified B-cell biomarkers that are reduced by aging and that can be used as predictive markers of the response of an individual to vaccination. The identification of these biomarkers will have an impact on the development of effective vaccines to protect the elderly from infections and other debilitating diseases.
KEYWORDS:
Activation-induced cytidine deaminase; Antibody vaccine response; Class switch recombination
PMID: 26420712 [PubMed - in process]
Activation-Induced Cytidine Deaminase and Switched Memory B Cells as Predictors of Effective In Vivo Responses to the Influenza Vaccine.
Frasca D1, Diaz A2, Blomberg BB2.
Author information
Abstract
Aging impairs humoral immune responses, leading to increased frequency and severity of infectious diseases and reduced protective effects of vaccination. We have identified B-cell biomarkers that are reduced by aging and that can be used as predictive markers of the response of an individual to vaccination. The identification of these biomarkers will have an impact on the development of effective vaccines to protect the elderly from infections and other debilitating diseases.
KEYWORDS:
Activation-induced cytidine deaminase; Antibody vaccine response; Class switch recombination
PMID: 26420712 [PubMed - in process]