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J Infect Dis. 2015 Feb 23. pii: jiv087. [Epub ahead of print]
Safety and Immunogenicity of a Single Low or High Dose of Clade 2 H5N1 Inactivated Influenza Vaccine in Adults Previously Primed with Clade 1 H5N1 Vaccine.
Winokur PL1, Patel SM2, Brady R3, Chen WH4, El-Kamary SS4, Edwards K5, Creech CB5, Frey S6, Keitel WA7, Belshe R6, Walter E8, Bellamy A9, Hill H9.
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Abstract
H5N1 influenza vaccination strategies that improve the immunological speed and cross-clade protection are desired. We compared the immunogenicity of a single 15 or 90 mcg dose of A/H5N1/Indonesia/05/05 (Clade 2) vaccine in adults who were previously primed with A/H5N1/Vietnam/1203/2004 (Clade 1) vaccine. High dose vaccine resulted in significantly higher titers to both clade 1 and 2 antigens. Clade 2 titers were unaffected by the previous dose of clade 1 vaccine. Low dose priming with a mismatched pandemic H5N1 vaccine would improve the rapidity, magnitude and cross reactivity of the immunological response following a single high dose, unadjuvanted, pandemic vaccine.
? The Author 2015. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.
PMID: 25712967 [PubMed - as supplied by publisher]
Safety and Immunogenicity of a Single Low or High Dose of Clade 2 H5N1 Inactivated Influenza Vaccine in Adults Previously Primed with Clade 1 H5N1 Vaccine.
Winokur PL1, Patel SM2, Brady R3, Chen WH4, El-Kamary SS4, Edwards K5, Creech CB5, Frey S6, Keitel WA7, Belshe R6, Walter E8, Bellamy A9, Hill H9.
Author information
Abstract
H5N1 influenza vaccination strategies that improve the immunological speed and cross-clade protection are desired. We compared the immunogenicity of a single 15 or 90 mcg dose of A/H5N1/Indonesia/05/05 (Clade 2) vaccine in adults who were previously primed with A/H5N1/Vietnam/1203/2004 (Clade 1) vaccine. High dose vaccine resulted in significantly higher titers to both clade 1 and 2 antigens. Clade 2 titers were unaffected by the previous dose of clade 1 vaccine. Low dose priming with a mismatched pandemic H5N1 vaccine would improve the rapidity, magnitude and cross reactivity of the immunological response following a single high dose, unadjuvanted, pandemic vaccine.
? The Author 2015. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.
PMID: 25712967 [PubMed - as supplied by publisher]