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Nephrology (Carlton). 2015 Feb 6. doi: 10.1111/nep.12416. [Epub ahead of print]
A randomised trial investigating the safety and efficacy of influenza vaccination in patients with ANCA-associated vasculitis.
Jeffs LS1, Peh CA, Jose MD, Lange K, Hurtado PR.
Author information
Abstract
AIM:
This study evaluated the safety and efficacy of influenza vaccination in patients with anti-neutrophil cytoplasmic antibody associated vasculitis.
METHODS:
31 patients who were in remission were randomised to receive either a trivalent influenza vaccine or no vaccine. Vaccine efficacy was assessed at 28 days. Patients were followed for 6 months for signs of reactivation of disease. In addition, 67 healthy individuals were randomised to receive either the influenza vaccine or no vaccine to assess its potential for triggering the formation of autoantibodies.
RESULTS:
Compared to patients who did not receive the vaccine, vaccinated patients achieved effective responses to all 3 influenza vaccine antigens. There was no significant change in levels of anti-neutrophil cytoplasmic antibody post-vaccination. There was no significant change in disease activity in vaccinated patients compared to non-vaccinated patients. Among vaccinated healthy individuals, we did not observe any significant change in the level of autoantibodies measured.
CONCLUSION:
This study shows that the administration of influenza vaccine to patients in remission with anti-neutrophil cytoplasmic antibody associated vasculitis is both safe and modestly efficacious.
This article is protected by copyright. All rights reserved.
KEYWORDS:
Anti-neutrophil cytoplasmic antibody; Influenza vaccination; anti-neutrophil cytoplasmic antibody associated vasculitis; immunosuppression; seroconversion; vasculitis
PMID: 25656094 [PubMed - as supplied by publisher]
A randomised trial investigating the safety and efficacy of influenza vaccination in patients with ANCA-associated vasculitis.
Jeffs LS1, Peh CA, Jose MD, Lange K, Hurtado PR.
Author information
Abstract
AIM:
This study evaluated the safety and efficacy of influenza vaccination in patients with anti-neutrophil cytoplasmic antibody associated vasculitis.
METHODS:
31 patients who were in remission were randomised to receive either a trivalent influenza vaccine or no vaccine. Vaccine efficacy was assessed at 28 days. Patients were followed for 6 months for signs of reactivation of disease. In addition, 67 healthy individuals were randomised to receive either the influenza vaccine or no vaccine to assess its potential for triggering the formation of autoantibodies.
RESULTS:
Compared to patients who did not receive the vaccine, vaccinated patients achieved effective responses to all 3 influenza vaccine antigens. There was no significant change in levels of anti-neutrophil cytoplasmic antibody post-vaccination. There was no significant change in disease activity in vaccinated patients compared to non-vaccinated patients. Among vaccinated healthy individuals, we did not observe any significant change in the level of autoantibodies measured.
CONCLUSION:
This study shows that the administration of influenza vaccine to patients in remission with anti-neutrophil cytoplasmic antibody associated vasculitis is both safe and modestly efficacious.
This article is protected by copyright. All rights reserved.
KEYWORDS:
Anti-neutrophil cytoplasmic antibody; Influenza vaccination; anti-neutrophil cytoplasmic antibody associated vasculitis; immunosuppression; seroconversion; vasculitis
PMID: 25656094 [PubMed - as supplied by publisher]