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Vaccine. 2009 Apr 30. [Epub ahead of print]
CROSS-REACTIVE ANTIBODIES IN MIDDLE-AGED AND ELDERLY VOLUNTEERS AFTER MF59-ADJUVANTED SUBUNIT TRIVALENT INFLUENZA VACCINE AGAINST B VIRUSES OF THE B/VICTORIA OR B/YAMAGATA LINEAGES.
Camilloni B, Neri M, Lepri E, Iorio AM. - Department of Medical and Surgical Specialties and Public Health, University of Perugia, Via del Giochetto, 06126 Perugia, Italy.
This study evaluated whether MF59-adjuvanted subunit trivalent influenza vaccine for the 2003/04 winter season (A/Moscow/10/99, H3N2; A/New Caledonia/20/99, H1N1; B/Hong Kong/330/01) would confer protection against mismatched and frequently co-circulating variants of influenza B/Victoria- and B/Yamagata-like virus strains.
Haemagglutination inhibiting (HI) antibodies were measured in middle-aged and elderly volunteers against the homologous B/Victoria-like vaccine strain (B/Hong Kong/330/01) and against mismatched B/Victoria-like (B/Malaysia/2506/04) and B/Yamagata-like (B/Singapore/379/99 and B/Shanghai/361/02) strains.
Immunization induced significant increases in the amounts of HI antibodies against all influenza B strains under investigation.
However, the responses against the heterologous B/Shanghai/361/02 virus did not reach the desirable values of seroprotection.
An age-dependent decline of the responses was found for B/Victoria-like antigens, but not for B/Yamagata-like strains.
Although further studies are needed, our data support the recommendation of including influenza B viruses of the B/Victoria and B/Yamagata lineages in the future influenza vaccine preparations.
PMID: 19410623 [PubMed - as supplied by publisher]
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CROSS-REACTIVE ANTIBODIES IN MIDDLE-AGED AND ELDERLY VOLUNTEERS AFTER MF59-ADJUVANTED SUBUNIT TRIVALENT INFLUENZA VACCINE AGAINST B VIRUSES OF THE B/VICTORIA OR B/YAMAGATA LINEAGES.
Camilloni B, Neri M, Lepri E, Iorio AM. - Department of Medical and Surgical Specialties and Public Health, University of Perugia, Via del Giochetto, 06126 Perugia, Italy.
This study evaluated whether MF59-adjuvanted subunit trivalent influenza vaccine for the 2003/04 winter season (A/Moscow/10/99, H3N2; A/New Caledonia/20/99, H1N1; B/Hong Kong/330/01) would confer protection against mismatched and frequently co-circulating variants of influenza B/Victoria- and B/Yamagata-like virus strains.
Haemagglutination inhibiting (HI) antibodies were measured in middle-aged and elderly volunteers against the homologous B/Victoria-like vaccine strain (B/Hong Kong/330/01) and against mismatched B/Victoria-like (B/Malaysia/2506/04) and B/Yamagata-like (B/Singapore/379/99 and B/Shanghai/361/02) strains.
Immunization induced significant increases in the amounts of HI antibodies against all influenza B strains under investigation.
However, the responses against the heterologous B/Shanghai/361/02 virus did not reach the desirable values of seroprotection.
An age-dependent decline of the responses was found for B/Victoria-like antigens, but not for B/Yamagata-like strains.
Although further studies are needed, our data support the recommendation of including influenza B viruses of the B/Victoria and B/Yamagata lineages in the future influenza vaccine preparations.
PMID: 19410623 [PubMed - as supplied by publisher]
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