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Infection. 2013 Nov 1. [Epub ahead of print]
Development of universal influenza vaccines based on influenza virus M and NP genes.
Zheng M, Luo J, Chen Z.
Source
Shanghai Institute of Biological Products, Shanghai, 200052, China.
Abstract
PURPOSE:
Vaccination is the safest and most effective measure against influenza virus infections. However, traditional influenza vaccines cannot respond effectively to an unforeseen epidemic or pandemic caused by a virus with antigenic drifts or antigenic shifts. Therefore, developing a universal influenza vaccine (UIV) that induces broad-spectrum and long-term immunity has become a major trend in influenza vaccine research and development.
METHODS:
This article reviews the development of UIVs based on these conserved influenza virus proteins.
RESULTS AND CONCLUSION:
The matrix protein (M1, M2) and nucleoprotein (NP) of influenza viruses have highly conserved sequences, and they become the major target antigens of current UIV studies.
PMID:
24178189
[PubMed - as supplied by publisher]
Development of universal influenza vaccines based on influenza virus M and NP genes.
Zheng M, Luo J, Chen Z.
Source
Shanghai Institute of Biological Products, Shanghai, 200052, China.
Abstract
PURPOSE:
Vaccination is the safest and most effective measure against influenza virus infections. However, traditional influenza vaccines cannot respond effectively to an unforeseen epidemic or pandemic caused by a virus with antigenic drifts or antigenic shifts. Therefore, developing a universal influenza vaccine (UIV) that induces broad-spectrum and long-term immunity has become a major trend in influenza vaccine research and development.
METHODS:
This article reviews the development of UIVs based on these conserved influenza virus proteins.
RESULTS AND CONCLUSION:
The matrix protein (M1, M2) and nucleoprotein (NP) of influenza viruses have highly conserved sequences, and they become the major target antigens of current UIV studies.
PMID:
24178189
[PubMed - as supplied by publisher]
