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Pediatr Infect Dis J. 2013 Jan 18. [Epub ahead of print]
Benefit of Conjugate Pneumococcal Vaccination in Preventing Influenza Hospitalization in Children: A Case-Control Study.
Dom?nguez A, Castilla J, Godoy P, Delgado-Rodr?guez M, Saez M, Soldevila N, Astray J, Mayoral JM, Mart?n V, Quintana JM, Gonz?lez-Candelas F, Gal?n JC, Tamames S, Castro A, Baricot M, Gar?n O, Garc?a JJ, Moraga F, Pumarola T; for the CIBERESP Cases and Controls in Pandemic Influenza Working Group, Spain.
Source
a Department de Salut P?blica. Universitat de Barcelona. Barcelona, Spain b CIBER Epidemiolog?a y Salud P?blica (CIBERESP). Madrid, Spain c Instituto de Salud P?blica de Navarra. Pamplona, Spain d Department de Salut. Generalitat de Catalunya. Barcelona, Spain e Universidad de Jaen. Jaen, Spain f GRECS, Universitat de Girona. Girona, Spain g ?rea de Epidemiolog?a. Comunidad de Madrid. Madrid, Spain h ervicio de Vigilancia de Andalucia, Spain i Instituto de Biomedicina. Universidad de Leon. Le?n, Spain j Unidad de Investigaci?n, Hospital Galdakao-Usansolo. San Sebastian, Spain k Centro Superior de Investigaci?n en Salud P?blica. Universidad de Valencia, Spain l Hospital Universitario Ram?n y Cajal. Madrid, Spain m Direcci?n General de Salud P?blica e Investigaci?n, Desarrollo e Innovaci?n. Junta de Castilla y Le?n, Spain n CIBER Enfermedades Respiratorias, Spain o Institut Municipal d' Investigaci? M?dica, Barcelona, Spain p Hospital Universitari San Joan de D?u, Esplugues, Spain q Hospital Universitari Vall d' Hebr?n r Red Espa?ola de Investigaci?n en Patolog?a Infecciosa (REIPI), Spain.
Abstract
BACKGROUND:: The pneumococcal conjugate vaccine (PCV) might prevent hospitalizations in children because of the role of S. pneumoniae in the complications of influenza infection. We investigated the benefit of PCV vaccination in preventing influenza hospitalization in children less than 5 years of age during the 2009-2010 pandemic wave and the 2010-2011 influenza epidemic in Spain. METHODS:: A multicenter matched case-control study was undertaken in 36 hospitals from 7 Spanish regions between July 2009 and April 2011. A case was defined as a hospitalized patient between 6 months and 5 years of age with influenza virus infection confirmed by real-time reverse-transcription polymerase chain reaction (RT-PCR). We selected two matched controls for each case from patients with unplanned hospital admission for reasons other than acute respiratory infection or influenza-like illness. Cases and controls were matched according to age, date of hospitalization and province of residence. Crude and adjusted odds ratios were calculated for associations between influenza hospitalization and PCV vaccination. RESULTS:: 194 cases and 342 controls were included in the study. In the 2009-2010 pandemic wave, the adjusted benefit in preventing hospitalization was 48% (95% CI, 1 to 76) in fully vaccinated children compared with -79% (95% CI, -341 to 27) in the 2010-2011 influenza season. CONCLUSIONS:: The results obtained suggest that, in children less than 5 years of age, PCV vaccination reduced hospitalization during the 2009 -2010 pandemic wave. By contrast, there was no observed benefit of vaccination in the 2010-2011 influenza season.
PMID:
23337901
[PubMed - as supplied by publisher]
Benefit of Conjugate Pneumococcal Vaccination in Preventing Influenza Hospitalization in Children: A Case-Control Study.
Dom?nguez A, Castilla J, Godoy P, Delgado-Rodr?guez M, Saez M, Soldevila N, Astray J, Mayoral JM, Mart?n V, Quintana JM, Gonz?lez-Candelas F, Gal?n JC, Tamames S, Castro A, Baricot M, Gar?n O, Garc?a JJ, Moraga F, Pumarola T; for the CIBERESP Cases and Controls in Pandemic Influenza Working Group, Spain.
Source
a Department de Salut P?blica. Universitat de Barcelona. Barcelona, Spain b CIBER Epidemiolog?a y Salud P?blica (CIBERESP). Madrid, Spain c Instituto de Salud P?blica de Navarra. Pamplona, Spain d Department de Salut. Generalitat de Catalunya. Barcelona, Spain e Universidad de Jaen. Jaen, Spain f GRECS, Universitat de Girona. Girona, Spain g ?rea de Epidemiolog?a. Comunidad de Madrid. Madrid, Spain h ervicio de Vigilancia de Andalucia, Spain i Instituto de Biomedicina. Universidad de Leon. Le?n, Spain j Unidad de Investigaci?n, Hospital Galdakao-Usansolo. San Sebastian, Spain k Centro Superior de Investigaci?n en Salud P?blica. Universidad de Valencia, Spain l Hospital Universitario Ram?n y Cajal. Madrid, Spain m Direcci?n General de Salud P?blica e Investigaci?n, Desarrollo e Innovaci?n. Junta de Castilla y Le?n, Spain n CIBER Enfermedades Respiratorias, Spain o Institut Municipal d' Investigaci? M?dica, Barcelona, Spain p Hospital Universitari San Joan de D?u, Esplugues, Spain q Hospital Universitari Vall d' Hebr?n r Red Espa?ola de Investigaci?n en Patolog?a Infecciosa (REIPI), Spain.
Abstract
BACKGROUND:: The pneumococcal conjugate vaccine (PCV) might prevent hospitalizations in children because of the role of S. pneumoniae in the complications of influenza infection. We investigated the benefit of PCV vaccination in preventing influenza hospitalization in children less than 5 years of age during the 2009-2010 pandemic wave and the 2010-2011 influenza epidemic in Spain. METHODS:: A multicenter matched case-control study was undertaken in 36 hospitals from 7 Spanish regions between July 2009 and April 2011. A case was defined as a hospitalized patient between 6 months and 5 years of age with influenza virus infection confirmed by real-time reverse-transcription polymerase chain reaction (RT-PCR). We selected two matched controls for each case from patients with unplanned hospital admission for reasons other than acute respiratory infection or influenza-like illness. Cases and controls were matched according to age, date of hospitalization and province of residence. Crude and adjusted odds ratios were calculated for associations between influenza hospitalization and PCV vaccination. RESULTS:: 194 cases and 342 controls were included in the study. In the 2009-2010 pandemic wave, the adjusted benefit in preventing hospitalization was 48% (95% CI, 1 to 76) in fully vaccinated children compared with -79% (95% CI, -341 to 27) in the 2010-2011 influenza season. CONCLUSIONS:: The results obtained suggest that, in children less than 5 years of age, PCV vaccination reduced hospitalization during the 2009 -2010 pandemic wave. By contrast, there was no observed benefit of vaccination in the 2010-2011 influenza season.
PMID:
23337901
[PubMed - as supplied by publisher]
