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Use of intranasal live attenuated influenza vaccine in individuals with asthma or a history of wheezing
Use of intranasal live attenuated influenza vaccine in individuals with asthma or a history of wheezing
Hum Vaccin Immunother. 2012 Feb 1;8(2). [Epub ahead of print]
Use of intranasal live attenuated influenza vaccine in individuals with asthma or a history of wheezing.
Ambrose CS.
Source
MedImmune, LLC, Medical and Scientific Affairs, One MedImmune Way, Gaithersburg, MD 20878, United States.
PMID:
22426366
[PubMed - as supplied by publisher]
Re: Use of intranasal live attenuated influenza vaccine in individuals with asthma or a history of wheezing
Hum Vaccin Immunother. 2012 Feb 1;8(2). [Epub ahead of print] Response to Christopher S. Ambrose: Use of live attenuated influenza vaccine in individuals with asthma or a history of wheezing :
Esposito S.
Source
Department of Maternal and Infantile Sciences, University of Milan, Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Via Commenda 9, Milan, NA 20122, Italy.
Abstract
The risk of bronchospasm should still be considered as greatly limiting the use of live attenuated influenza vaccine (LAIV) in children with asthma or history of recurrent wheezing because in some cases a child could have severe asthma at onset that becomes mild with asthma prophylaxis or conversely could have recurrent wheezing in the first years of life before developing later severe asthma. Consequently, the conclusion could be that pediatricians would prefer to avoid any risk and use another influenza vaccine in children with asthma or recurrent wheezing, especially if they consider that immunogenicity and efficacy of influenza vaccination is better in children > 2 years (when LAIV can be administered) in comparison with the younger ones. An interesting information should be to know data on respiratory. Further comprehensive multicenter studies in children and adults with asthma or a history of recurrent wheezing should be useful to clarify safety data of LAIV in these populations.
PMID:
22426362
[PubMed - as supplied by publisher]
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