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Clin Exp Immunol. 2012 Apr;168(1):135-141. doi: 10.1111/j.1365-2249.2011.04550.x.
Immunoglobulin G subclass levels and antibody responses to the 2009 influenza A (H1N1) monovalent vaccine among human immunodeficiency virus (HIV)-infected and HIV-uninfected adults.
Crum-Cianflone NF, Collins G, Defang G, Iverson E, Eberly LE, Duplessis C, Maguire J, Ganesan A, Agan BK, Lalani T, Whitman T, Brandt C, Faix D, Blair PJ, Burgess T.
Source
Infectious Disease Clinical Research Program, Uniformed Services University of the Health Sciences Naval Medical Research Center Infectious Disease Clinic, National Naval Medical Center, Bethesda, MD Infectious Disease Clinic, Naval Medical Center San Diego Naval Health Research Center, San Diego, CA Division of Biostatistics, University of Minnesota, Minneapolis, MN Infectious Disease Clinic, Naval Medical Center Portsmouth, VA, USA.
Abstract
Immunoglobulin (Ig)G levels are important for antibody vaccine responses and IgG subclass deficiencies have been associated with severe 2009 influenza A (H1N1) infections. Studies have demonstrated variations in immune responses to the H1N1 vaccine, but the aetiology of this is unknown. We determined the associations between pre-vaccination overall and influenza-specific IgG subclass levels and 2009 H1N1-specific antibody responses post-vaccination (robust versus poor at day 28) stratified by human immunodeficiency virus (HIV) status. Logistic regression models were utilized to evaluate whether pre-vaccination IgG subclass levels were associated with the antibody response generated post-vaccination. We evaluated 48 participants as part of a clinical study who were stratified by robust versus poor post-vaccination immune responses. Participants had a median age of 35 years; 92% were male and 44% were Caucasian. HIV-infected adults had a median CD4 count of 669 cells/mm(3) , and 79% were receiving highly active anti-retroviral therapy. HIV-infected participants were more likely to have IgG2 deficiency (<240 mg/dl) than HIV-uninfected individuals (62% versus 4%, P < 0?001). No association of pre-vaccination IgG subclass levels (total or influenza-specific) and the antibody response generated by HIN1 vaccination in either group was found. In summary, pre-vaccination IgG subclass levels did not correlate with the ability to develop robust antibody responses to the 2009 influenza A (H1N1) monovalent vaccine. IgG2 deficiencies were common among HIV-infected individuals but did not correlate with poor influenza vaccine responses. Further investigations into the aetiology of disparate vaccine responses are needed.
? 2011 The Authors. Clinical and Experimental Immunology ? 2011 British Society for Immunology.
PMID:
22385248
[PubMed - as supplied by publisher]
Immunoglobulin G subclass levels and antibody responses to the 2009 influenza A (H1N1) monovalent vaccine among human immunodeficiency virus (HIV)-infected and HIV-uninfected adults.
Crum-Cianflone NF, Collins G, Defang G, Iverson E, Eberly LE, Duplessis C, Maguire J, Ganesan A, Agan BK, Lalani T, Whitman T, Brandt C, Faix D, Blair PJ, Burgess T.
Source
Infectious Disease Clinical Research Program, Uniformed Services University of the Health Sciences Naval Medical Research Center Infectious Disease Clinic, National Naval Medical Center, Bethesda, MD Infectious Disease Clinic, Naval Medical Center San Diego Naval Health Research Center, San Diego, CA Division of Biostatistics, University of Minnesota, Minneapolis, MN Infectious Disease Clinic, Naval Medical Center Portsmouth, VA, USA.
Abstract
Immunoglobulin (Ig)G levels are important for antibody vaccine responses and IgG subclass deficiencies have been associated with severe 2009 influenza A (H1N1) infections. Studies have demonstrated variations in immune responses to the H1N1 vaccine, but the aetiology of this is unknown. We determined the associations between pre-vaccination overall and influenza-specific IgG subclass levels and 2009 H1N1-specific antibody responses post-vaccination (robust versus poor at day 28) stratified by human immunodeficiency virus (HIV) status. Logistic regression models were utilized to evaluate whether pre-vaccination IgG subclass levels were associated with the antibody response generated post-vaccination. We evaluated 48 participants as part of a clinical study who were stratified by robust versus poor post-vaccination immune responses. Participants had a median age of 35 years; 92% were male and 44% were Caucasian. HIV-infected adults had a median CD4 count of 669 cells/mm(3) , and 79% were receiving highly active anti-retroviral therapy. HIV-infected participants were more likely to have IgG2 deficiency (<240 mg/dl) than HIV-uninfected individuals (62% versus 4%, P < 0?001). No association of pre-vaccination IgG subclass levels (total or influenza-specific) and the antibody response generated by HIN1 vaccination in either group was found. In summary, pre-vaccination IgG subclass levels did not correlate with the ability to develop robust antibody responses to the 2009 influenza A (H1N1) monovalent vaccine. IgG2 deficiencies were common among HIV-infected individuals but did not correlate with poor influenza vaccine responses. Further investigations into the aetiology of disparate vaccine responses are needed.
? 2011 The Authors. Clinical and Experimental Immunology ? 2011 British Society for Immunology.
PMID:
22385248
[PubMed - as supplied by publisher]
