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Vaccine. 2012 Jan 20. [Epub ahead of print]
Safety, immunogenicity, and efficacy of an alphavirus replicon-based swine influenza virus hemagglutinin vaccine.
Veen RL, Loynachan AT, Mogler MA, Russell BJ, Harris HD, Kamrud KI.
Source
Harrisvaccines, Inc., 1102 Southern Hills Drive, Ames, IA 50010, USA; Immunobiology Program, Iowa State University, Ames, IA 50011, USA; Department of Veterinary Microbiology and Preventative Medicine, College of Veterinary Medicine, Iowa State University, Ames, IA 50011, USA.
Abstract
A single-cycle, propagation-defective replicon particle (RP) vaccine expressing a swine influenza virus hemagglutinin (HA) gene was constructed and evaluated in several different animal studies. Studies done in both the intended host (pigs) and non-host (mice) species demonstrated that the RP vaccine is not shed or spread by vaccinated animals to comingled cohorts, nor does it revert to virulence following vaccination. In addition, vaccinated pigs develop both specific humoral and IFN-γ immune responses, and young pigs are protected against homologous influenza virus challenge.
Copyright ? 2012. Published by Elsevier Ltd.
PMID:
22269873
[PubMed - as supplied by publisher]
Safety, immunogenicity, and efficacy of an alphavirus replicon-based swine influenza virus hemagglutinin vaccine.
Veen RL, Loynachan AT, Mogler MA, Russell BJ, Harris HD, Kamrud KI.
Source
Harrisvaccines, Inc., 1102 Southern Hills Drive, Ames, IA 50010, USA; Immunobiology Program, Iowa State University, Ames, IA 50011, USA; Department of Veterinary Microbiology and Preventative Medicine, College of Veterinary Medicine, Iowa State University, Ames, IA 50011, USA.
Abstract
A single-cycle, propagation-defective replicon particle (RP) vaccine expressing a swine influenza virus hemagglutinin (HA) gene was constructed and evaluated in several different animal studies. Studies done in both the intended host (pigs) and non-host (mice) species demonstrated that the RP vaccine is not shed or spread by vaccinated animals to comingled cohorts, nor does it revert to virulence following vaccination. In addition, vaccinated pigs develop both specific humoral and IFN-γ immune responses, and young pigs are protected against homologous influenza virus challenge.
Copyright ? 2012. Published by Elsevier Ltd.
PMID:
22269873
[PubMed - as supplied by publisher]
