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Vaccine. 2011 Jun 29. [Epub ahead of print]
Effectiveness of the monovalent influenza A(H1N1)2009 vaccine in Navarre, Spain, 2009-2010: Cohort and case control study.
Castilla J, Mor?n J, Mart?nez-Artola V, Fern?ndez-Alonso M, Guevara M, Cenoz MG, Reina G, Alvarez N, Arriazu M, El?a F, Salcedo E, Barricarte A; The Primary Health Care Sentinel Network of Navarre.
Source
Instituto de Salud P?blica de Navarra, Pamplona, Spain; CIBER de Epidemiolog?a y Salud P?blica, Spain.
Abstract
We defined a population-based cohort (596,755 subjects) in Navarre, Spain, using electronic records from physicians, to evaluate the effectiveness of the monovalent A(H1N1)2009 vaccine in preventing influenza in the 2009-2010 pandemic season. During the 9-week period of vaccine availability and circulation of the A(H1N1)2009 virus, 4608 cases of medically attended influenza-like illness (MA-ILI) were registered (46 per 1000 person-years). After adjustment for sociodemographic covariables, outpatient visits and major chronic conditions, vaccination was associated with a 32% (95% CI: 8-50%) reduction in the overall incidence of MA-ILI. In a test negative case-control analysis nested in the cohort, swabs from 633 patients were included, and 123 were confirmed for A(H1N1)2009 influenza. No confirmed case had received A(H1N1)2009 vaccine versus 9.6% of controls (p<0.001). The vaccine effectiveness in preventing laboratory-confirmed influenza was 89% (95% CI: 36-100%) after adjusting for age, health care setting, major chronic conditions and period. Pandemic vaccine was effective in preventing MA-ILI and confirmed cases of influenza A(H1N1)2009 in the 2009-2010 season.
Copyright ? 2011. Published by Elsevier Ltd.
PMID:
21723358
[PubMed - as supplied by publisher]
Effectiveness of the monovalent influenza A(H1N1)2009 vaccine in Navarre, Spain, 2009-2010: Cohort and case control study.
Castilla J, Mor?n J, Mart?nez-Artola V, Fern?ndez-Alonso M, Guevara M, Cenoz MG, Reina G, Alvarez N, Arriazu M, El?a F, Salcedo E, Barricarte A; The Primary Health Care Sentinel Network of Navarre.
Source
Instituto de Salud P?blica de Navarra, Pamplona, Spain; CIBER de Epidemiolog?a y Salud P?blica, Spain.
Abstract
We defined a population-based cohort (596,755 subjects) in Navarre, Spain, using electronic records from physicians, to evaluate the effectiveness of the monovalent A(H1N1)2009 vaccine in preventing influenza in the 2009-2010 pandemic season. During the 9-week period of vaccine availability and circulation of the A(H1N1)2009 virus, 4608 cases of medically attended influenza-like illness (MA-ILI) were registered (46 per 1000 person-years). After adjustment for sociodemographic covariables, outpatient visits and major chronic conditions, vaccination was associated with a 32% (95% CI: 8-50%) reduction in the overall incidence of MA-ILI. In a test negative case-control analysis nested in the cohort, swabs from 633 patients were included, and 123 were confirmed for A(H1N1)2009 influenza. No confirmed case had received A(H1N1)2009 vaccine versus 9.6% of controls (p<0.001). The vaccine effectiveness in preventing laboratory-confirmed influenza was 89% (95% CI: 36-100%) after adjusting for age, health care setting, major chronic conditions and period. Pandemic vaccine was effective in preventing MA-ILI and confirmed cases of influenza A(H1N1)2009 in the 2009-2010 season.
Copyright ? 2011. Published by Elsevier Ltd.
PMID:
21723358
[PubMed - as supplied by publisher]
