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Expert Rev Vaccines
. 2023 Oct 19.
doi: 10.1080/14760584.2023.2272655. Online ahead of print. Immune response and safety of inactivated SARS-CoV-2 vaccines during pregnancy: a real-world observational study
Yajie Gong 1 2 , Xi Zhang 1 2 , Xue Han 1 2 , Baolan Chen 1 2 3 , Yingxia Xu 1 2 3 , Jitian Huang 1 2 3 , Wenhan Yang 1 3 , Xi Fu 1 3 , Qiancui Wang 4 , Zhongjun Li 5 , Chunfeng Wu 6 , Tianran Shen 1 3 , Yuting Fan 1 2 3 , Yingshi Dai 1 2 3 , Yaping Qiao 7 , Gang Zeng 7 , Jikai Zhang 8 , Qingsong Chen 1 2 3
Affiliations
Background: As pregnant women are excluded from clinical trials of inactivated SARS-CoV-2 vaccines, it is important to assess the immune response in women receiving the vaccination while unknowingly pregnant.
Methods: In a multicenter cross-sectional study, we enrolled 873 pregnant women aged 18-45 years. Serum antibody levels induced by inactivated vaccines were determined. Adverse events were collected by self-reported survey after vaccination. Logistic regression model and restricted cubic spline model were used to investigate the association of factors with antibody positivity.
Results: As the doses of the vaccine increase, neutralizing antibody (NAb) positivity was 98.3%, 39.5%, and 9.5% in pregnant women, respectively. The dose of vaccine and duration since vaccination were associated with NAb positivity. The OR of two and three doses of vaccines were 7.20 and 458.33 (P < 0.05). NAb levels and duration since vaccination showed a linear relationship in pregnant women vaccinated two doses, with a decrease to a near seropositivity threshold at 22 weeks. Adverse events were mainly mild or moderate after vaccinated during pregnancy, with no increase in incidence compared with whom vaccinated during pre-pregnancy.
Conclusions: The use of inactivated vaccines during pregnancy induced favorable immune persistence, and the incidence of adverse events did not increase.
Keywords: Coronavirus disease 2019 (COVID-19); immune response; inactivated vaccine; pregnancy; safety.
. 2023 Oct 19.
doi: 10.1080/14760584.2023.2272655. Online ahead of print. Immune response and safety of inactivated SARS-CoV-2 vaccines during pregnancy: a real-world observational study
Yajie Gong 1 2 , Xi Zhang 1 2 , Xue Han 1 2 , Baolan Chen 1 2 3 , Yingxia Xu 1 2 3 , Jitian Huang 1 2 3 , Wenhan Yang 1 3 , Xi Fu 1 3 , Qiancui Wang 4 , Zhongjun Li 5 , Chunfeng Wu 6 , Tianran Shen 1 3 , Yuting Fan 1 2 3 , Yingshi Dai 1 2 3 , Yaping Qiao 7 , Gang Zeng 7 , Jikai Zhang 8 , Qingsong Chen 1 2 3
Affiliations
- PMID: 37855091
- DOI: 10.1080/14760584.2023.2272655
Background: As pregnant women are excluded from clinical trials of inactivated SARS-CoV-2 vaccines, it is important to assess the immune response in women receiving the vaccination while unknowingly pregnant.
Methods: In a multicenter cross-sectional study, we enrolled 873 pregnant women aged 18-45 years. Serum antibody levels induced by inactivated vaccines were determined. Adverse events were collected by self-reported survey after vaccination. Logistic regression model and restricted cubic spline model were used to investigate the association of factors with antibody positivity.
Results: As the doses of the vaccine increase, neutralizing antibody (NAb) positivity was 98.3%, 39.5%, and 9.5% in pregnant women, respectively. The dose of vaccine and duration since vaccination were associated with NAb positivity. The OR of two and three doses of vaccines were 7.20 and 458.33 (P < 0.05). NAb levels and duration since vaccination showed a linear relationship in pregnant women vaccinated two doses, with a decrease to a near seropositivity threshold at 22 weeks. Adverse events were mainly mild or moderate after vaccinated during pregnancy, with no increase in incidence compared with whom vaccinated during pre-pregnancy.
Conclusions: The use of inactivated vaccines during pregnancy induced favorable immune persistence, and the incidence of adverse events did not increase.
Keywords: Coronavirus disease 2019 (COVID-19); immune response; inactivated vaccine; pregnancy; safety.