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Intern Med
. 2023;62(16):2381-2387.
doi: 10.2169/internalmedicine.1631-23. Epub 2023 Aug 15. Acute Interstitial Nephritis with Glomerular Capillary IgA Deposition Following SARS-CoV-2 mRNA Vaccination
Erika Hishida 1 , Yuko Ono 2 , Kazuho Oe 1 , Toshimi Imai 1 , Hiromichi Yoshizawa 1 , Takeo Nakaya 3 , Hirotoshi Kawata 3 , Tetsu Akimoto 1 , Osamu Saito 1 , Daisuke Nagata 1
Affiliations
We herein report a case of acute kidney injury (AKI) presenting as acute interstitial nephritis (AIN) after the first dose of the BNT162b2 mRNA vaccine against coronavirus disease 2019 (COVID-19). A 69-year-old man with a history of diabetes and hypertension presented with AKI 4 days after receiving the vaccine. Despite the administration of methylprednisolone pulse treatment, his renal function worsened, which prompted us to initiate temporal hemodialysis. His renal function subsequently improved, and a renal biopsy confirmed AIN and glomerular capillary IgA deposition without apparent crescents. The clinical history and histological findings suggest a relationship between severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination and AIN as a rare side effect.
Keywords: COVID-19; SARS-CoV-2; acute interstitial nephritis; acute kidney injury; capillary IgA deposition; vaccination.
. 2023;62(16):2381-2387.
doi: 10.2169/internalmedicine.1631-23. Epub 2023 Aug 15. Acute Interstitial Nephritis with Glomerular Capillary IgA Deposition Following SARS-CoV-2 mRNA Vaccination
Erika Hishida 1 , Yuko Ono 2 , Kazuho Oe 1 , Toshimi Imai 1 , Hiromichi Yoshizawa 1 , Takeo Nakaya 3 , Hirotoshi Kawata 3 , Tetsu Akimoto 1 , Osamu Saito 1 , Daisuke Nagata 1
Affiliations
- PMID: 37587055
- DOI: 10.2169/internalmedicine.1631-23
We herein report a case of acute kidney injury (AKI) presenting as acute interstitial nephritis (AIN) after the first dose of the BNT162b2 mRNA vaccine against coronavirus disease 2019 (COVID-19). A 69-year-old man with a history of diabetes and hypertension presented with AKI 4 days after receiving the vaccine. Despite the administration of methylprednisolone pulse treatment, his renal function worsened, which prompted us to initiate temporal hemodialysis. His renal function subsequently improved, and a renal biopsy confirmed AIN and glomerular capillary IgA deposition without apparent crescents. The clinical history and histological findings suggest a relationship between severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination and AIN as a rare side effect.
Keywords: COVID-19; SARS-CoV-2; acute interstitial nephritis; acute kidney injury; capillary IgA deposition; vaccination.